Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells

2015 ◽  
Vol 55 (5) ◽  
pp. 918-928 ◽  
Author(s):  
Boyun Kim ◽  
Hee Seung Kim ◽  
Eun-Ji Jung ◽  
Jung Yun Lee ◽  
Benjamin K. Tsang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cervical Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cervical Cancer Cells ◽  
Selective Generation

scholarly journals Nisin induces apoptosis in cervical cancer cells via reactive oxygen species generation and mitochondrial membrane potential changes

2022 ◽  
Author(s):  
Houri Sadri ◽  
Mahmoud Aghaei ◽  
Vajihe Akbari
Keyword(s):  
Reactive Oxygen Species ◽  
Cervical Cancer ◽  
Membrane Potential ◽  
Cancer Cells ◽  
Mitochondrial Membrane Potential ◽  
Mtt Assay ◽  
Mitochondrial Membrane ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cervical Cancer Cells

Nisin, an antimicrobial peptide produced by Lactococcus lactis, is widely used as a safe food preservative and has been recently attracting the attention of many researchers as a potential anticancer agent. The cytotoxicity of nisin against HeLa, OVCAR-3, SK-OV-3, and HUVEC cells was evaluated using MTT assay. The apoptotic effect of nisin was identified by Annexin-V/propidium iodide assay, and then it was further confirmed by western blotting analysis, mitochondrial membrane potential (ΔΨm) analysis, and reactive oxygen species (ROS) assay. The MTT assay showed concentration-dependent cytotoxicity of nisin towards cancer cell lines, with the IC50 values of 11.5-23 µM, but less toxicity against normal endothelial cells. Furthermore, treatment of cervical cancer cells with 12 µM nisin significantly (P<0.05) increased the Bax/Bcl-2 ratio (4.9-fold), reduced ΔΨm (70%), and elevated ROS levels (1.7-fold). These findings indicated that nisin might have anticancer and apoptogenic activities through mitochondrial dysfunction and oxidative stress damage in cervical cancer cells.

Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells

2004 ◽  
Vol 40 (4) ◽  
pp. 201-211 ◽  
Author(s):  
Priya Srinivas ◽  
Gokul Gopinath ◽  
Asoke Banerji ◽  
Abhilash Dinakar ◽  
Gopal Srinivas
Keyword(s):  
Reactive Oxygen Species ◽  
Cervical Cancer ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

scholarly journals Alpha-mangostin induces apoptosis through activation of reactive oxygen species and ASK1/p38 signaling pathway in cervical cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (29) ◽  
pp. 47425-47439 ◽  
Author(s):  
Chien-Hsing Lee ◽  
Tsung-Ho Ying ◽  
Hui-Ling Chiou ◽  
Shu-Ching Hsieh ◽  
Shiua-Hua Wen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cervical Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cervical Cancer Cells
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