Deoxycholic acid promotes the growth of colonic aberrant crypt foci

2006 ◽  
Vol 46 (1) ◽  
pp. 60-70 ◽  
Author(s):  
Christopher Flynn ◽  
David C. Montrose ◽  
Daniel L. Swank ◽  
Masako Nakanishi ◽  
Jillian N.M. Ilsley ◽  
...  
Keyword(s):  
Deoxycholic Acid ◽  
Aberrant Crypt Foci

Glutathione- S -transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid

2004 ◽  
Vol 127 (2) ◽  
pp. 428-443 ◽  
Author(s):  
Atsushi Nobuoka ◽  
Tetsuji Takayama ◽  
Koji Miyanishi ◽  
Tsutomu Sato ◽  
Kunihiro Takanashi ◽  
...  
Keyword(s):  
Deoxycholic Acid ◽  
Aberrant Crypt Foci ◽  
Glutathione S Transferase

scholarly journals Metabolism of deoxycholic acid in bile fistula patients

1971 ◽  
Vol 12 (6) ◽  
pp. 688-691
Author(s):  
RUSSELL F. HANSON ◽  
GALE WILLIAMS
Keyword(s):  
Deoxycholic Acid ◽  
Bile Fistula

scholarly journals Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in Combination with Quercetin Inhibit Colorectal Cancer Development in ApcMin/+ Mice

2021 ◽  
Vol 22 (9) ◽  
pp. 4906
Author(s):  
Iván Benito ◽  
Ignacio J. Encío ◽  
Fermín I. Milagro ◽  
María Alfaro ◽  
Ana Martínez-Peñuela ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Weight Loss ◽  
Dietary Supplementation ◽  
Bifidobacterium Bifidum ◽  
Aberrant Crypt Foci ◽  
Intestinal Bleeding ◽  
Standard Diet ◽  
Colon Tissue ◽  
Lactobacillus Gasseri ◽  
Reduced Body

Recent studies have suggested that flavonoids such as quercetin and probiotics such as Bifidobacterium bifidum (Bf) and Lactobacillus gasseri (Lg) could play a relevant role in inhibiting colon cancer cell growth. Our study investigated the role of dietary supplementation with microencapsulated probiotics (Bf and Lg) along with quercetin in the development of mouse colorectal cancer (CRC). Methods: Adenomatous polyposis coli/multiple intestinal neoplasia (ApcMin/+) mice were fed a standard diet or the same diet supplemented with microencapsulated probiotics (Bf and Lg strains, 107 CFU/100 g food) or both probiotics strains plus microencapsulated quercetin (15 mg/100 g food) for 73 days. Changes in body and organ weights, energy metabolism, intestinal microbiota, and colon tissue were determined. The expression of genes related to the Wnt pathway was also analyzed in colon samples. Results: Dietary supplementation with microencapsulated probiotics or microencapsulated probiotics plus quercetin reduced body weight loss and intestinal bleeding in ApcMin/+ mice. An improvement in energy expenditure was observed after 8 weeks but not after 10 weeks of treatment. A supplemented diet with microencapsulated Bf and Lg reduced the number of aberrant crypt foci (ACF) and adenomas by 45% and 60%, respectively, whereas the supplementation with Bf, Lg and quercetin decreased the number of ACF and adenomas by 57% and 80%, respectively. Microencapsulated Bf and Lg in combination with quercetin could exert inhibition of the canonical Wnt/β-catenin signaling pathway in the colon of ApcMin/+ mice Conclusions: The administration of microencapsulated Bf and Lg, individually or in combination with quercetin, inhibits the CRC development in ApcMin/+ mice.

Deoxycholic acid enhancement of lymphocyte migration through direct interaction with the intestinal vascular endothelium

2021 ◽  
Author(s):  
Naoki Shibuya ◽  
Masaaki Higashiyama ◽  
Yoshihiro Akita ◽  
Kazuhiko Shirakabe ◽  
Suguru Ito ◽  
...  
Keyword(s):  
Vascular Endothelium ◽  
Deoxycholic Acid ◽  
Direct Interaction ◽  
Lymphocyte Migration

scholarly journals An N-acyl glycyltaurine conjugate of deoxycholic acid in the biliary bile acids of the rabbit

1998 ◽  
Vol 39 (11) ◽  
pp. 2119-2124 ◽  
Author(s):  
Lee R. Hagey ◽  
Claudio D. Schteingart ◽  
Steven S. Rossi ◽  
H-T. Ton-Nu ◽  
Alan F. Hofmann
Keyword(s):  
Bile Acids ◽  
Deoxycholic Acid

scholarly journals Drawbacks in the use of 23-nor-deoxycholic acid standards.

1982 ◽  
Vol 23 (1) ◽  
pp. 211-215
Author(s):  
A F Attili ◽  
M Angelico ◽  
L Capocaccia ◽  
U Pièche ◽  
A Cantafora
Keyword(s):  
Deoxycholic Acid

Predictive value of rectal aberrant crypt foci for intraepithelial neoplasia in ulcerative colitis – a cross-sectional study

2014 ◽  
Vol 49 (10) ◽  
pp. 1219-1229 ◽  
Author(s):  
Paulo Freire ◽  
Pedro Figueiredo ◽  
Ricardo Cardoso ◽  
Maria Manuel Donato ◽  
Manuela Ferreira ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Predictive Value ◽  
Intraepithelial Neoplasia ◽  
Cross Sectional Study ◽  
Aberrant Crypt Foci ◽  
Sectional Study ◽  
Cross Sectional
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