Deoxycholic acid enhancement of lymphocyte migration through direct interaction with the intestinal vascular endothelium

2021 ◽  
Author(s):  
Naoki Shibuya ◽  
Masaaki Higashiyama ◽  
Yoshihiro Akita ◽  
Kazuhiko Shirakabe ◽  
Suguru Ito ◽  
...  
Keyword(s):  
Vascular Endothelium ◽  
Deoxycholic Acid ◽  
Direct Interaction ◽  
Lymphocyte Migration

Coronary vasodilation mediated by T cells expressing choline acetyltransferase

2021 ◽  
Vol 321 (5) ◽  
pp. H933-H939
Author(s):  
Adrian H. Chester ◽  
Ann McCormack ◽  
Edmund J. Miller ◽  
Mohamed N. Ahmed ◽  
Magdi H. Yacoub
Keyword(s):  
T Cells ◽  
Blood Flow ◽  
Blood Vessel ◽  
Coronary Blood Flow ◽  
Choline Acetyltransferase ◽  
Vascular Endothelium ◽  
Coronary Circulation ◽  
Direct Interaction ◽  
Coronary Vasodilation ◽  
Ischemic Events

This study shows ChAT-expressing T cells can induce vasodilation of the blood vessel in the coronary circulation and that this effect relies on a direct interaction between T cells and the coronary vascular endothelium. The study establishes a potential immunomodulatory role for T cells in the coronary circulation. The present findings offer an additional possibility that a deficiency of ChAT-expressing T cells could contribute to reduced coronary blood flow and ischemic events in the myocardium.

scholarly journals THE MIGRATION OF LYMPHOCYTES ACROSS THE VASCULAR ENDOTHELIUM IN LYMPHOID TISSUE

1972 ◽  
Vol 136 (3) ◽  
pp. 568-588 ◽  
Author(s):  
G. I. Schoefl ◽  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelium ◽  
Lymphoid Tissue ◽  
Electron Microscope Study ◽  
Fluid Loss ◽  
Serial Sections ◽  
Lymphocyte Migration ◽  
Cell Cytoplasm ◽  
Endothelial Layer ◽  
Special Adaptation

An electron microscope study was made of the mode of lymphocyte migration across the endothelial layer of venules in the Peyer's patches of mice and rats. Single and serial sections were examined. Of a total of about 800 lymphocytes observed in single sections, 91% were located between endothelial cells and 9% were surrounded by endothelial cytoplasm in the particular plane of section. 62% of the lymphocytes occurred in groups of two or more. In long sequences of serial sections through 21 endothelial cells, all lymphocytes were located external to the endothelial cells though some appeared "internal" at certain levels of sectioning. The probability that a lymphocyte which appears to be surrounded by endothelial cell cytoplasm actually lies within the cell was analyzed with a mathematical model derived from data obtained from single sections. The results of this analysis suggested that at least 93–99% of lymphocytes (within 90% limits of confidence) take an intercellular path in their migration from blood to lymph. It is concluded that lymphocytes migrate across the vascular endothelium by insinuating themselves between endothelial cells and not by passing through them. Rather than constituting an increased barrier to cell migration, the unusual height of the endothelial cells in these vessels is interpreted to be a special adaptation which allows sustained cell traffic without excessive fluid loss taking place concomitantly.

scholarly journals Sa1119 – Deoxycholic Acid Enhances Lymphocyte Migration to the Small Intestinal Microvessels Possibly Through Enhancing Expression of Adhesion Molecules on Epithelium

2019 ◽  
Vol 156 (6) ◽  
pp. S-275
Author(s):  
Naoki Shibuya ◽  
Masaaki Higashiyama ◽  
Shin Nishii ◽  
Akinori Mizoguchi ◽  
Kenichi Inaba ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Deoxycholic Acid ◽  
Lymphocyte Migration ◽  
Small Intestinal

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines

10.1038/88710 ◽  
2001 ◽  
Vol 2 (6) ◽  
pp. 515-522 ◽  
Author(s):  
Guy Cinamon ◽  
Vera Shinder ◽  
Ronen Alon
Keyword(s):  
Vascular Endothelium ◽  
Lymphocyte Migration ◽  
Shear Forces

Nutrient-regulated gene expression in eukaryotes

2006 ◽  
Vol 73 ◽  
pp. 85-96 ◽  
Author(s):  
Richard J. Reece ◽  
Laila Beynon ◽  
Stacey Holden ◽  
Amanda D. Hughes ◽  
Karine Rébora ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcriptional Control ◽  
Direct Interaction ◽  
Signalling Pathways ◽  
A Cell ◽  
One Step ◽  
Higher Eukaryotes ◽  
Regulated Gene Expression

The recognition of changes in environmental conditions, and the ability to adapt to these changes, is essential for the viability of cells. There are numerous well characterized systems by which the presence or absence of an individual metabolite may be recognized by a cell. However, the recognition of a metabolite is just one step in a process that often results in changes in the expression of whole sets of genes required to respond to that metabolite. In higher eukaryotes, the signalling pathway between metabolite recognition and transcriptional control can be complex. Recent evidence from the relatively simple eukaryote yeast suggests that complex signalling pathways may be circumvented through the direct interaction between individual metabolites and regulators of RNA polymerase II-mediated transcription. Biochemical and structural analyses are beginning to unravel these elegant genetic control elements.

Demonstration of a direct interaction between a colonic divalent cation receptor and the basolateral Na−H exchanger

2001 ◽  
Vol 120 (5) ◽  
pp. A529-A530
Author(s):  
P GEIBEL ◽  
M OREILLY ◽  
H VIEWEGER ◽  
K SIEBERT ◽  
N OBREIN ◽  
...  
Keyword(s):  
Divalent Cation ◽  
Direct Interaction ◽  
Cation Receptor

Polyphenolic compounds from Clusiaceae plants modulating angiogenesis and vascular endothelium

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
A Lavaud ◽  
R Soletti ◽  
P Richomme ◽  
R Andriantsitohaina ◽  
D Guilet
Keyword(s):  
Vascular Endothelium ◽  
Polyphenolic Compounds
Sign in / Sign up

Export Citation Format

Share Document