Cholesterol Modification of an Anticancer Drug for Efficient Incorporation into a Supramolecular Hydrogel System

2018 ◽  
Vol 39 (17) ◽  
pp. 1800007 ◽  
Author(s):  
Maarten H. Bakker ◽  
Maxime Grillaud ◽  
Dan Jing Wu ◽  
Peter-Paul K. H. Fransen ◽  
Ignace H. de Hingh ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Supramolecular Hydrogel ◽  
Cholesterol Modification ◽  
Hydrogel System

Design of a micellized α-cyclodextrin based supramolecular hydrogel system

Soft Matter ◽  
2015 ◽  
Vol 11 (27) ◽  
pp. 5425-5434 ◽  
Author(s):  
Anis Abdul Karim ◽  
Xian Jun Loh
Keyword(s):  
Sustained Release ◽  
Supramolecular Hydrogel ◽  
System P ◽  
First Time ◽  
Step Mechanism ◽  
Hydrogel System

This study describes, for the first time, a two-step mechanism of a supramolecular hydrogel system to engineer an injectable gel depot for controlled/sustained release of actives.

Novel supramolecular hydrogel/micelle composite for co-delivery of anticancer drug and growth factor

Soft Matter ◽  
2012 ◽  
Vol 8 (13) ◽  
pp. 3665 ◽  
Author(s):  
Dong Ma ◽  
Hong-Bin Zhang ◽  
Kai Tu ◽  
Li-Ming Zhang
Keyword(s):  
Growth Factor ◽  
Anticancer Drug ◽  
Supramolecular Hydrogel

The aromaticity of the phenyl ring imparts thermal stability to a supramolecular hydrogel obtained from low molecular mass compound

2019 ◽  
Vol 43 (31) ◽  
pp. 12396-12409
Author(s):  
Dhanya Mahalakshmi Murali ◽  
Ganesh Shanmugam
Keyword(s):  
Thermal Stability ◽  
Molecular Mass ◽  
Phenyl Ring ◽  
Supramolecular Hydrogel ◽  
Hydrogel System

Using Fmoc-phenylalanine and Fmoc-cyclohexylalanine, we show that the aromaticity of the phenyl ring imparts significant thermal stability to a supramolecular hydrogel system and its significance depends on the method of inducing hydrogelation.

scholarly journals Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 1693-1699 ◽  
Author(s):  
Bingxia Li ◽  
Luna Zhang ◽  
Zichen Zhang ◽  
Ruoqing Gao ◽  
Hongmei Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Photothermal Therapy ◽  
Supramolecular Hydrogel ◽  
Sustained Drug Release ◽  
Release Characteristic ◽  
Hydrogel System

The F127-GO-DOX supramolecular hydrogel system with sustained drug release characteristic for chemotherapy and photothermal therapy.

Anticancer drug discovery from filamentous fungi

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
NH Oberlies ◽  
A Sy ◽  
TN Graf ◽  
DJ Kroll ◽  
Y Nakanishi ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Filamentous Fungi ◽  
Anticancer Drug ◽  
Anticancer Drug Discovery

Development of Taxol® as an anticancer drug

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DGI Kingston
Keyword(s):  
Anticancer Drug

A Boronic Acid-Based Fluorescence Hydrogel for Monosaccharide Detection

2018 ◽  
Author(s):  
Suying Xu ◽  
Adam Sedgwick ◽  
Souad Elfecky ◽  
Wenbo Chen ◽  
Ashley Jones ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Boronic Acid ◽  
Binding Constants ◽  
Strong Fluorescence ◽  
Fluorescence Response ◽  
Turn On ◽  
Fluorescence Turn On ◽  
Hydrogel System

<p>A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection<i>. </i>In solution, the fluorescent probe<b> </b>displayed a strong fluorescence turn-on response upon exposure to fructose, and an expected trend in apparent binding constants, as judged by a fluorescence response where D-fructose > D-galactose > D-mannose > D-glucose. The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of fructose resulting in a 10-fold enhancement (≤ 0.25 M). <b><u></u></b></p>

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