Design of a micellized α-cyclodextrin based supramolecular hydrogel system

Soft Matter ◽  
2015 ◽  
Vol 11 (27) ◽  
pp. 5425-5434 ◽  
Author(s):  
Anis Abdul Karim ◽  
Xian Jun Loh

This study describes, for the first time, a two-step mechanism of a supramolecular hydrogel system to engineer an injectable gel depot for controlled/sustained release of actives.

2015 ◽  
Vol 13 (8) ◽  
pp. 2260-2263 ◽  
Author(s):  
Di Xu ◽  
Li Dai ◽  
Marta Catellani ◽  
Elena Motti ◽  
Nicola Della Ca’ ◽  
...  

Chiral dibenzopyran derivatives were obtained by cinchona alkaloid, as organocatalyst, in combination, for the first time, with palladium/norbornene catalytic system.


Author(s):  
Anastasia Marinopoulou

In his systems’ theory, Luhmann attempts to redefine communication, and associates it with information. For Luhmann, communication is distinct from action (Handeln), and the rationality of the scientific system resides in the notion of Zweck, or in the ends of the sciences towards action. For the first time in the epistemological history of modernity, rationality is understood as a certain scientific purpose of action and not as the critique of scientific truth and validity of reason. The schism that Luhmann brought about between ‘traditional’ epistemology (reconsidered now as novel) and the ‘critical’ theory of science (seen by Luhmann as ‘traditional’) was irredeemable. In the following pages, I maintain that all evidence to the contrary such a divergence was inherent to modernity.Drawing on the Schützean model of multiple realities, Luhmann manages to blur the distinction between instrumentality and rationality by relativizing both within systemic complexity. According to Luhmann, complexity characterizes a multifaceted social system, such as science itself. However, I argue that where complexity, in Luhmann, interprets the systemic, it also employs presentism and partial situationalism to explain the essence and methodology of science as a system.


Author(s):  
Eric Scerri

Our story begins, somewhat arbitrarily, in the English city of Manchester around the turn of the nineteenth century. There, a child prodigy by the name of John Dalton, at the tender age of fifteen is teaching in a school with his older brother. Within a few years, John Dalton’s interests have developed to encompass meteorology, physics, and chemistry. Among the questions that puzzle him is why the various component gases in the air such as oxygen, nitrogen, and carbon dioxide do not separate from each other. Why does the mixture of gases in the air remain as a homogeneous mixture? As a result of pursuing this question, Dalton develops what is to become modern atomic theory. The ultimate constituents of all substances, he supposes, are hard microscopic spheres or atoms that were first discussed by the ancient Greek philosophers and taken up again by modern scientists like Newton, Gassendi, and Boscovich. But Dalton goes a good deal further than all of these thinkers in establishing one all-important quantitative characteristic for each kind of atom, namely its weight. This he does by considering quantitative data on chemical experiments. For example, he finds that the ratio for the weight in which hydrogen and oxygen combine together is one to eight. Dalton assumes that water consists of one atom of each of these two elements. He takes a hydrogen atom to have a weight of 1 unit and therefore reasons that oxygen must have a weight of 8 units. Similarly, he deduces the weights for a number of other atoms and even molecules as we now call them. For the first time the elements acquire a quantitative property, by means of which they may be compared. This feature will eventually lead to an accurate classification of all the elements in the form of the periodic system, but this is yet to come. Before that can happen the notion of atoms provokes tremendous debates and disagreements among the experts of Dalton’s day.


The Analyst ◽  
2015 ◽  
Vol 140 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Guifen Jie ◽  
Yingqiang Qin ◽  
Qingmin Meng ◽  
Jialin Wang

Electrochemiluminescence energy transfer from CdSe QDs to folic acid was applied for the first time for amplified detection of DNA by a DNAzyme autocatalytic system.


CrystEngComm ◽  
2014 ◽  
Vol 16 (32) ◽  
pp. 7575-7579 ◽  
Author(s):  
Yong Chan Cho ◽  
Bum-Su Kim ◽  
Hanbyeol Yoo ◽  
Ji Young Kim ◽  
Seunghun Lee ◽  
...  

By using grain-free single crystal specimens, the melting of Cu and Ag using electrostatic levitation (ESL) and obtaining their high-temperature densities were accomplished for the first time.


2015 ◽  
Vol 51 (83) ◽  
pp. 15294-15296 ◽  
Author(s):  
Ying Zhou ◽  
Hongjing Cui ◽  
Chang Shu ◽  
Ya Ling ◽  
Ran Wang ◽  
...  

In this communication we report the first supramolecular hydrogel based on an antiepileptic drug carbamazepine (CBZ). CBZ plays a dual role of a drug molecule and an aromatic capping group in this self-delivery system.


2007 ◽  
Vol 57 (4) ◽  
pp. 429-439
Author(s):  
Bistra Kostova ◽  
Dimitar Rachev

New co-polymer zwitterionic matrices for sustained release of verapamil hydrochlorideStable co-polymer [vinyl acetate-co-3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonate, p(VA-co-DMAPS)] latex of different compositions has been synthesized for the first time by emulsifier-free emulsion copolymerization. The unusual >>overshooting<< behavior of the co-polymer tablets has been explained by the formation of specific clusters from the opposite oriented dipoles-zwitterionic species. The change of their concentration with the DMAPS unit fraction (mDMAPS), pH and ionic strength has been considered responsible for the differences observed in the swelling kinetics. The results obtained prove that mDMAPSand ionic strength could be used to control the swelling degree of the p(VA-co-DMAPS) matrices and their sustained drug delivery. In this way, p(VA-co-DMAPS) matrices could be effectively used to control the sustained release of drugs with basic properties like verapamil hydrochloride from model tablets.


2018 ◽  
Vol 20 (1) ◽  
pp. 113-117 ◽  
Author(s):  
Xunbo Lu ◽  
Yufeng Shi ◽  
Fangrui Zhong
Keyword(s):  
System P ◽  

An efficient Rh-catalyzed intermolecular C(sp3)–H amination in a purely aqueous system is developed for the first time.


2002 ◽  
Vol 22 (22) ◽  
pp. 7780-7789 ◽  
Author(s):  
Kaye N. Truscott ◽  
Nils Wiedemann ◽  
Peter Rehling ◽  
Hanne Müller ◽  
Chris Meisinger ◽  
...  

ABSTRACT The mitochondrial intermembrane space contains a protein complex essential for cell viability, the Tim9-Tim10 complex. This complex is required for the import of hydrophobic membrane proteins, such as the ADP/ATP carrier (AAC), into the inner membrane. Different views exist about the role played by the Tim9-Tim10 complex in translocation of the AAC precursor across the outer membrane. For this report we have generated a new tim10 yeast mutant that leads to a strong defect in AAC import into mitochondria. Thereby, for the first time, authentic AAC is stably arrested in the translocase complex of the outer membrane (TOM), as shown by antibody shift blue native electrophoresis. Surprisingly, AAC is still associated with the receptors Tom70 and Tom20 when the function of Tim10 is impaired. The nonessential Tim8-Tim13 complex of the intermembrane space is not involved in the transfer of AAC across the outer membrane. These results define a two-step mechanism for translocation of AAC across the outer membrane. The initial insertion of AAC into the import channel is independent of the function of Tim9-Tim10; however, completion of translocation across the outer membrane, including release from the TOM complex, requires a functional Tim9-Tim10 complex.


2014 ◽  
Vol 2 (15) ◽  
pp. 5363-5370 ◽  
Author(s):  
Wei Wang ◽  
Huan Qi ◽  
Haibo Long ◽  
Xiaoyang Wang ◽  
Hongqiang Ru

It is for the first time demonstrated that clew-like silica particles with complex hierarchically meso–mesoporous structures can be prepared via a simple TEOS/HCl(aq.)/P123 ternary non-ionic templating system.


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