scholarly journals Post-Functionalization of Polymers via Orthogonal Ligation Chemistry

2013 ◽  
Vol 34 (10) ◽  
pp. 810-849 ◽  
Author(s):  
Anja S. Goldmann ◽  
Mathias Glassner ◽  
Andrew J. Inglis ◽  
Christopher Barner-Kowollik
Keyword(s):  
Functionalization Of Polymers ◽  
Post Functionalization

Post-Functionalization of Polymers via Orthogonal Ligation Chemistry

2015 ◽  
pp. 395-465
Author(s):  
Anja S. Goldmann ◽  
Mathias Glassner ◽  
Andrew J. Inglis ◽  
Christopher Barner-Kowollik
Keyword(s):  
Functionalization Of Polymers ◽  
Post Functionalization

Photoredox catalyst-mediated atom transfer radical addition for polymer functionalization under visible light

2014 ◽  
Vol 5 (10) ◽  
pp. 3321-3325 ◽  
Author(s):  
Jiangtao Xu ◽  
Amir Atme ◽  
Ana Flavia Marques Martins ◽  
Kenward Jung ◽  
Cyrille Boyer
Keyword(s):  
Visible Light ◽  
Radical Addition ◽  
Atom Transfer ◽  
Functionalization Of Polymers ◽  
Atom Transfer Radical Addition ◽  
Post Functionalization

A facile method for post-functionalization of polymers with side olefin groups was developed by visible light-mediated atom transfer radical addition (ATRA) employing a photoredox catalyst, fac-Ir(ppy)3.

Double click reaction strategies for polymer conjugation and post-functionalization of polymers

2012 ◽  
Vol 3 (4) ◽  
pp. 825-835 ◽  
Author(s):  
Hakan Durmaz ◽  
Amitav Sanyal ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Click Reaction ◽  
Functionalization Of Polymers ◽  
Polymer Conjugation ◽  
Post Functionalization

Imine as a Linchpin Approach for Distal C(sp2)–H Functionalization

2020 ◽  
Author(s):  
Sukdev Bag ◽  
Sadhan Jana ◽  
Sukumar Pradhan ◽  
Suman Bhowmick ◽  
Nupur Goswami ◽  
...  
Keyword(s):  
Organic Molecules ◽  
Bond Activation ◽  
Bond Formation ◽  
Ancillary Ligand ◽  
Significant Challenge ◽  
Site Selectivity ◽  
Directing Group ◽  
Covalently Linked ◽  
Complex Organic ◽  
Post Functionalization

<p>Despite the widespread applications of C–H functionalization, controlling site selectivity remains a significant challenge. Covalently attached directing group (DG) served as an ancillary ligand to ensure proximal <i>ortho</i>-, distal <i>meta</i>- and <i>para</i>-C-H functionalization over the last two decades. These covalently linked DGs necessitate two extra steps for a single C–H functionalization: introduction of DG prior to C–H activation and removal of DG post-functionalization. We introduce here a transient directing group for distal C(<i>sp<sup>2</sup></i>)-H functionalization <i>via</i> reversible imine formation. By overruling facile proximal C-H bond activation by imine-<i>N</i> atom, a suitably designed pyrimidine-based transient directing group (TDG) successfully delivered selective distal C-C bond formation. Application of this transient directing group strategy for streamlining the synthesis of complex organic molecules without any necessary pre-functionalization at the distal position has been explored.</p>

scholarly journals Achieving selectivity in porphyrin bromination through a DoE-driven optimization under continuous flow conditions

2020 ◽  
Author(s):  
Paolo Zardi ◽  
Michele Maggini ◽  
Tommaso Carofiglio
Keyword(s):  
Reaction Time ◽  
Design Of Experiment ◽  
Continuous Flow ◽  
Optimization Process ◽  
Porphyrin Ring ◽  
Flow Conditions ◽  
Reaction Parameters ◽  
Synthetic Procedure ◽  
Relevant Factors ◽  
Post Functionalization

AbstractThe post-functionalization of porphyrins through the bromination in β position of the pyrrolic rings is a relevant transformation because the resulting bromoderivatives are useful synthons to covalently link a variety of chemical architectures to a porphyrin ring. However, single bromination of porphyrins is a challenging reaction for the abundancy of reactive β-pyrrolic positions in the aromatic macrocycle. We herein report a synthetic procedure for the efficient preparation of 2-bromo-5,10,15,20-tetraphenylporphyrin (1) under continuous flow conditions. The use of flow technology allows to reach an accurate control over critical reaction parameters such as temperature and reaction time. Furthermore, by performing the optimization process through a statistical DoE (Design of Experiment) approach, these parameters could be properly adjusted with a limited number of experiments. This process led us to a better understanding of the relevant factors that govern porphyrins monobromination and to obtain compound 1 with an unprecedent 80% yield.

scholarly journals Convenient Access to Functionalized Non-Symmetrical Atropisomeric 4,4′-Bipyridines

Compounds ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 58-74
Author(s):  
Emmanuel Aubert ◽  
Emmanuel Wenger ◽  
Paola Peluso ◽  
Victor Mamane
Keyword(s):  
Solid State ◽  
Intermolecular Interactions ◽  
Medicinal Chemistry ◽  
Crystal Packing ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Halogen Bonds ◽  
Cross Coupling Reactions ◽  
Cyano Groups ◽  
Post Functionalization

Non-symmetrical chiral 4,4′-bipyridines have recently found interest in organocatalysis and medicinal chemistry. In this regard, the development of efficient methods for their synthesis is highly desirable. Herein, a series of non-symmetrical atropisomeric polyhalogenated 4,4′-bipyridines were prepared and further functionalized by using cross-coupling reactions. The desymmetrization step is based on the N-oxidation of one of the two pyridine rings of the 4,4′-bipyridine skeleton. The main advantage of this methodology is the possible post-functionalization of the pyridine N-oxide, allowing selective introduction of chlorine, bromine or cyano groups in 2- and 2′-postions of the chiral atropisomeric 4,4′-bipyridines. The crystal packing in the solid state of some newly prepared derivatives was analyzed and revealed the importance of halogen bonds in intermolecular interactions.

scholarly journals A post-functionalization toolbox for diazonium (electro)-grafted surfaces: review of the coupling methods

2021 ◽  
Author(s):  
Christelle Gautier ◽  
Isidoro López ◽  
Tony Breton
Keyword(s):  
Coupling Methods ◽  
Wide Range ◽  
2D Nanomaterials ◽  
Post Functionalization

Tailored 2D-nanomaterials can be prepared from diazonium electrografted surfaces through a wide range of post-functionalization approaches.

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