Effect of Thermal Processing on the Dynamic/Isothermal Crystallization and Cytocompatibility of Polylactic Acid for Biomedical Applications

2021 ◽  
pp. 2100274
Author(s):  
Sandra C. Cifuentes ◽  
Laura Saldaña ◽  
José Luis Gónzalez‐Carrasco ◽  
Rosario Benavente ◽  
Alberto García‐Peñas
Keyword(s):  
Polylactic Acid ◽  
Thermal Processing ◽  
Isothermal Crystallization ◽  
Biomedical Applications

scholarly journals Synthesis and Biological Application of Polylactic Acid

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5023
Author(s):  
Ge Li ◽  
Menghui Zhao ◽  
Fei Xu ◽  
Bo Yang ◽  
Xiangyu Li ◽  
...  
Keyword(s):  
Physical Properties ◽  
Polylactic Acid ◽  
Biomedical Applications ◽  
Raw Materials ◽  
Raw Material ◽  
Biomedical Materials ◽  
Biomedical Material ◽  
Sugar Fermentation ◽  
Low Toxicity ◽  
Good Biocompatibility

Over the past few decades, with the development of science and technology, the field of biomedicine has rapidly developed, especially with respect to biomedical materials. Low toxicity and good biocompatibility have always been key targets in the development and application of biomedical materials. As a degradable and environmentally friendly polymer, polylactic acid, also known as polylactide, is favored by researchers and has been used as a commercial material in various studies. Lactic acid, as a synthetic raw material of polylactic acid, can only be obtained by sugar fermentation. Good biocompatibility and biodegradability have led it to be approved by the U.S. Food and Drug Administration (FDA) as a biomedical material. Polylactic acid has good physical properties, and its modification can optimize its properties to a certain extent. Polylactic acid blocks and blends play significant roles in drug delivery, implants, and tissue engineering to great effect. This article describes the synthesis of polylactic acid (PLA) and its raw materials, physical properties, degradation, modification, and applications in the field of biomedicine. It aims to contribute to the important knowledge and development of PLA in biomedical applications.

Ceramic Additive Manufacturing Using VAT Photopolymerization

2018 ◽  
Author(s):  
Diptanshu ◽  
Erik Young ◽  
Chao Ma ◽  
Suleiman Obeidat ◽  
Bo Pang ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Additive Manufacturing ◽  
Thermal Processing ◽  
Biomedical Applications ◽  
Ceramic Materials ◽  
Ceramic Suspension ◽  
Alumina Particles ◽  
Compressive Testing ◽  
The Difference ◽  
Porosity Percentage

The popularity of additive manufacturing for producing porous bio-ceramics using vat photopolymerization in the recent years has gained a lot of impetus due to its high resolution and low surface roughness. In this study, a commercial vat polymerization printer (Nobel Superfine, XYZprinting) was used to create green bodies using a ceramic suspension consisting of 10 vol.% of alumina particles in a photopolymerizable resin. Four different sizes of cubical green bodies were printed out. They were subjected to thermal processing which included de-binding to get rid of the polymer and thereafter sintering for joining of the ceramic particles. The porosity percentage of the four different sizes were measured and compared. The lowest porosity was observed in the smallest cubes (5 mm). It was found to be 43.3%. There was an increase in the porosity of the sintered parts for the larger cubes (10, 15 and 20 mm). However, the difference in the porosity among these sizes was not significant and ranged from 61.5% to 65.2%. The compressive testing of the samples showed that the strength of the 5-mm cube was the maximum among all samples and the compressive strength decreased as the size of the samples increased. These ceramic materials of various densities are of great interest for biomedical applications.

Silk and Wool Protein Microparticle-Reinforced Crystalline Polylactic Acid Biocomposites with Improved Cell Interaction for Targeted Biomedical Applications

2020 ◽  
Vol 2 (11) ◽  
pp. 4739-4751
Author(s):  
Purabi Bhagabati ◽  
Siddharth Mohan Bhasney ◽  
Devleena Bose ◽  
Rechana Remadevi ◽  
Mohan Setty ◽  
...  
Keyword(s):  
Polylactic Acid ◽  
Biomedical Applications ◽  
Cell Interaction

scholarly journals Polylactic acid: synthesis and biomedical applications

2019 ◽  
Vol 127 (6) ◽  
pp. 1612-1626 ◽  
Author(s):  
M.S. Singhvi ◽  
S.S. Zinjarde ◽  
D.V. Gokhale
Keyword(s):  
Polylactic Acid ◽  
Biomedical Applications ◽  
Acid Synthesis

scholarly journals Faster Release of Lumen-Loaded Drugs than Matrix-Loaded Equivalent in Polylactic Acid/Halloysite Nanotubes

Materials ◽  
2019 ◽  
Vol 12 (11) ◽  
pp. 1830 ◽  
Author(s):  
Chaitra Venkatesh ◽  
Oran Clear ◽  
Ian Major ◽  
John G. Lyons ◽  
Declan M. Devine
Keyword(s):  
Drug Delivery ◽  
Polylactic Acid ◽  
Biomedical Applications ◽  
Antiplatelet Agent ◽  
Numerical Data ◽  
Halloysite Nanotubes ◽  
Uv Spectrophotometry ◽  
Scanning Calorimetry ◽  
Model Drug

Nanocomposite-based drug delivery systems with intrinsic controlled release properties are of great interest in biomedical applications. We report a novel polylactic acid (PLA)/halloysite nanotube (HNT) nanocomposite-based drug delivery system. PLA/HNT nanocomposites have shown immense potential for use in biomedical applications due to their favorable cyto- and hemo-compatibility. The objective of this study was to evaluate the release of active pharmaceutical ingredients (API) from PLA/HNT composites matrix and the effect of preloading the API into the lumen of the HNT on its release profile. Aspirin was used in this study as a model drug as it is a common nonsteroidal anti-inflammatory and antiplatelet agent widely used for various medical conditions. These two types of drug-loaded PLA/HNT nanocomposites were characterised by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), surface wettability and mechanical testing. Statistical analysis was conducted on numerical data. Drug entrapment and in vitro drug release studies were conducted using UV spectrophotometry. Results indicate that aspirin was successfully loaded into the lumen of HNT, which resulted in the sustained release of aspirin from the nanocomposites. Furthermore, the addition of HNT into the polymer matrix increased the mechanical properties, indicating its suitability as a drug-eluting reinforcing agent.

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