“One-pot” Synthesis of 1-Vinyl-2-pyrrolidone with Protic Functional Groups in 3-Position

2009 ◽  
Vol 210 (22) ◽  
pp. 1973-1978 ◽  
Author(s):  
Mónica Pérez Perrino ◽  
Rodrigo Navarro ◽  
Myriam Gómez Tardajos ◽  
Alberto Gallardo ◽  
Helmut Reinecke
Keyword(s):  
Functional Groups ◽  
One Pot ◽  
One Pot Synthesis

Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽  
2020 ◽  
Vol 31 (14) ◽  
pp. 1430-1434
Author(s):  
Ming Bian ◽  
Jin-feng Zhou ◽  
Dong-min Tang
Keyword(s):  
Drug Discovery ◽  
Dimethyl Sulfoxide ◽  
Functional Groups ◽  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

A One-pot Synthesis of Novel Functionalized (E)-β-Arylvinyl Bromides from anti-2,3-Dibromo-3-(4-carboxyphenyl)propanoic Acid

2008 ◽  
Vol 63 (7) ◽  
pp. 865-870 ◽  
Author(s):  
Chunxiang Kuang ◽  
Yubo Jiang ◽  
Qing Yang ◽  
Wensheng Zhang ◽  
Yaolin Wen
Keyword(s):  
Functional Groups ◽  
Propanoic Acid ◽  
Aldehyde Ester ◽  
One Pot ◽  
One Pot Synthesis ◽  
High Yields

A facile one-pot synthesis of functionalized (E)-β -arylvinyl bromides bearing various 4-alkoxycarbonyl and 4-aryloxycarbonyl groups was achieved by debrominative decarboxylation of anti-2,3- dibromo-3-(4-carboxyphenyl)propanoic acid in the presence of AgOAc and subsequent esterification in the presence of dicyclohexyl carbodiimide and dimethylaminopyridine. This method gives (E)-β - arylvinyl bromides in high stereoselectivities and high yields, and tolerates aldehyde, ester, and nitro functional groups.

A Convenient, One-Pot Synthesis of Azulenes Having Versatile Functional Groups by the Reaction of 2H-Cyclohepta[b]furan-2-ones with Furan Derivatives

Heterocycles ◽  
1992 ◽  
Vol 34 (3) ◽  
pp. 429 ◽  
Author(s):  
Hidetsugu Wakabayashi ◽  
Paw-Wang Yang ◽  
Chi-Phi Wu ◽  
Kimio Shindo ◽  
Sumio Ishikawa ◽  
...  
Keyword(s):  
Functional Groups ◽  
One Pot ◽  
Furan Derivatives ◽  
One Pot Synthesis

Assembly of substituted phenanthridines via a cascade palladium-catalyzed coupling reaction, deprotection and intramolecular cyclization

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19571-19575 ◽  
Author(s):  
Jun Ge ◽  
Xiaojian Wang ◽  
Tianqi Liu ◽  
Zeyu Shi ◽  
Qiong Xiao ◽  
...  
Keyword(s):  
Functional Groups ◽  
Intramolecular Cyclization ◽  
Coupling Reaction ◽  
Practical Method ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed

A practical method for one-pot synthesis of substituted phenanthridines is described. Via this method, a series of substituted phenanthridines are obtained in good yields with remarkable functional groups compatibility.

A One-Pot Approach to 2-(N-Substituted Amino)-1,4-naphthoquinones with Use of Nitro Compounds and 1,4-Naphthoquinones in Water

Synlett ◽  
2019 ◽  
Vol 30 (05) ◽  
pp. 615-619 ◽  
Author(s):  
Ji-Yu Wang ◽  
Xu-Ling Chen ◽  
Yu Dong ◽  
Shuai He ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Functional Groups ◽  
Nitro Compounds ◽  
Reaction Conditions ◽  
One Pot ◽  
Aliphatic Nitro Compounds ◽  
Aromatic Nitro Compounds ◽  
One Pot Synthesis ◽  
Aromatic Nitro

A one-pot synthesis of 2-(N-substituted amino)-1,4-naphthoquinones from 1,4-naphthoquinones and nitro compounds in water has been developed. This method features mild reaction conditions and provides aromatic nitro compounds with various functional groups such as halogens, methylthio, ester, amide, even allyl, propargyl, and heterocycles, as well as aliphatic nitro compounds that are well tolerated. This method can be scaled up and we conducted further transformation of the obtained 2-(N-substituted amino)-1,4-naphthoquinones to synthesize carbazolequinone derivatives.

scholarly journals One-Pot Synthesis of B-Aryl Carboranes with Sensitive Functional Groups Using Sequential Cobalt- and Palladium-Catalyzed Reactions

Catalysts ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1348
Author(s):  
Sergey A. Anufriev ◽  
Akim V. Shmal’ko ◽  
Kyrill Yu. Suponitsky ◽  
Igor B. Sivaev
Keyword(s):  
Functional Groups ◽  
X Ray Diffraction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Palladium Catalyzed ◽  
Catalyzed Reactions ◽  
The One ◽  
Solid State Structures ◽  
Derivatives Of

The simple and efficient method was developed for the one-pot synthesis of B-substituted aryl derivatives of ortho-carborane with functional groups sensitive to organolithium and organomagnesium reagents using 9-iodo-ortho-carborane and generated in situ organozinc compounds. The method proposed was used to prepare a series of 9-aryl-ortho-carboranes, including those containing nitrile and ester groups, 9-RC6H4-1,2-C2B10H11 (R = p-Me, p-NMe2, p-OCH2OMe, o-OMe, p-OMe, o-CN, p-CN, o-COOEt, m-COOEt, and p-COOEt). It was demonstrated that the same approach can be used for synthesis of diaryl derivatives of ortho-carborane 9,12-(RC6H4)2-1,2-C2B10H10 (R = H, p-Me). The solid-state structures of 9-RC6H4-1,2-C2B10H11 (R = p-NMe2, p-OCH2OMe, o-OMe, o-CN, p-CN, m-COOEt, and p-COOEt) and 9,12-(p-MeC6H4)2-1,2-C2B10H10 were determined by single crystal X-ray diffraction.

scholarly journals Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles

2017 ◽  
Vol 13 ◽  
pp. 2596-2602 ◽  
Author(s):  
Angélica de Fátima S Barreto ◽  
Veronica Alves dos Santos ◽  
Carlos Kleber Z Andrade
Keyword(s):  
Functional Groups ◽  
Multicomponent Reactions ◽  
One Pot ◽  
Complex Molecules ◽  
One Pot Synthesis

Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained. Herein, we report the efficient application of this approach to the synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles. Our strategy was accomplished in only three steps: first, a one-pot hydrazino-Ugi-azide four-component reaction; second a hydrazinolysis and finally an additional hydrazino-Ugi-azide reaction. This sequence provides the title compounds in moderate to excellent yields. The products synthesized herein contain functional groups within their structures that can be easily modified to obtain new acylhydrazino 1,5-disubstituted tetrazoles.

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