A Cancer-Recognizing Polymeric Photosensitizer Based on the Tumor Extracellular pH Response of Conjugated Polymers for Targeted Cancer Photodynamic Therapy

2014 ◽  
Vol 14 (12) ◽  
pp. 1688-1695 ◽  
Author(s):  
Songhee Jeong ◽  
Wooram Park ◽  
Chung-Sung Lee ◽  
Kun Na
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Extracellular Ph ◽  
Ph Response

Isomeric Ir(iii) complexes for tracking mitochondrial pH fluctuations and inducing mitochondrial dysfunction during photodynamic therapy

2019 ◽  
Vol 48 (46) ◽  
pp. 17200-17209 ◽  
Author(s):  
Haijie Chen ◽  
Chen Ge ◽  
Huiqun Cao ◽  
Xuepeng Zhang ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mitochondrial Dysfunction ◽  
Ph Response ◽  
Ph Fluctuations

Two pairs of isomeric phosphorescent Ir(iii) complexes that show mitochondrial pH-response and induce mitochondrial dysfunction during photodynamic therapy.

Water-Soluble Conjugated Polymers for Simultaneous Two-Photon Cell Imaging and Two-Photon Photodynamic Therapy

2013 ◽  
Vol 1 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Xiaoqin Shen ◽  
Lin Li ◽  
Agnes Chow Min Chan ◽  
Nengyue Gao ◽  
Shao Q. Yao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Cell Imaging ◽  
Water Soluble ◽  
Two Photon

A zwitterionic red-emitting water-soluble conjugated polymer with high resistance to nonspecific binding for two-photon cell imaging and good singlet oxygen production capability

2021 ◽  
Author(s):  
Yan-Qin Huang ◽  
Shan-Shan Jiang ◽  
Li-Xiang Pan ◽  
Rui Zhang ◽  
Kun-Lin Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
High Resistance ◽  
Conjugated Polymer ◽  
Cell Imaging ◽  
Water Soluble ◽  
Oxygen Production ◽  
Nonspecific Binding ◽  
Two Photon

Water-soluble conjugated polymers (WSCPs) with dual capability of two-photon imaging and singlet oxygen (1O2) production have become one type of the most promising agents in noninvasive imaging guided photodynamic therapy...

Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for photothermal/photodynamic therapy

Nano Research ◽  
2014 ◽  
Vol 7 (9) ◽  
pp. 1291-1301 ◽  
Author(s):  
Nannan Wang ◽  
Zilong Zhao ◽  
Yifan Lv ◽  
Huanhuan Fan ◽  
Huarong Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Extracellular Ph ◽  
Gold Nanorod ◽  
Targeting Ability

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 4432-4441 ◽  
Author(s):  
Fujin Ai ◽  
Na Wang ◽  
Xiaoman Zhang ◽  
Tianying Sun ◽  
Qi Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Extracellular Ph ◽  
Upconversion Nanoparticles ◽  
Nir Light ◽  
Targeting Ability

Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT.

scholarly journals Sterol-Response Pathways Mediate Alkaline Survival in Diverse Fungi

mBio ◽  
2020 ◽  
Vol 11 (3) ◽  
Author(s):  
Hannah E. Brown ◽  
Calla L. Telzrow ◽  
Joseph W. Saelens ◽  
Larissa Fernandes ◽  
J. Andrew Alspaugh
Keyword(s):  
Cryptococcus Neoformans ◽  
Fungal Pathogens ◽  
Fungal Infections ◽  
Membrane Integrity ◽  
Extracellular Ph ◽  
Alkaline Ph ◽  
Content Type ◽  
Alkaline Environment ◽  
Ph Response ◽  
The Impact

ABSTRACT The ability for cells to maintain homeostasis in the presence of extracellular stress is essential for their survival. Stress adaptations are especially important for microbial pathogens to respond to rapidly changing conditions, such as those encountered during the transition from the environment to the infected host. Many fungal pathogens have acquired the ability to quickly adapt to changes in extracellular pH to promote their survival in the various microenvironments encountered during a host infection. For example, the fungus-specific Rim/Pal alkaline response pathway has been well characterized in many fungal pathogens, including Cryptococcus neoformans. However, alternative mechanisms for sensing and responding to host pH have yet to be extensively studied. Recent observations from a genetic screen suggest that the C. neoformans sterol homeostasis pathway is required for growth at elevated pH. This work explores interactions among mechanisms of membrane homeostasis, alkaline pH tolerance, and Rim pathway activation. We find that the sterol homeostasis pathway is necessary for growth in an alkaline environment and that an elevated pH is sufficient to induce Sre1 activation. This pH-mediated activation of the Sre1 transcription factor is linked to the biosynthesis of ergosterol but is not dependent on Rim pathway signaling, suggesting that these two pathways are responding to alkaline pH independently. Furthermore, we discover that C. neoformans is more susceptible to membrane-targeting antifungals under alkaline conditions, highlighting the impact of microenvironmental pH on the treatment of invasive fungal infections. Together, these findings further connect membrane integrity and composition with the fungal pH response and pathogenesis. IMPORTANCE The work described here further elucidates how microorganisms sense and adapt to changes in their environment to establish infections in the human host. Specifically, we uncover a novel mechanism by which an opportunistic human fungal pathogen, Cryptococcus neoformans, responds to increases in extracellular pH in order to survive and thrive within the relatively alkaline environment of the human lung. This mechanism, which is intimately linked with fungal membrane sterol homeostasis, is independent of the previously well-studied alkaline response Rim pathway. Furthermore, this ergosterol-dependent alkaline pH response is present in Candida albicans, indicating that this mechanism spans diverse fungal species. These results are also relevant for novel antimicrobial drug development as we show that currently used ergosterol-targeting antifungals are more active in alkaline environments.

In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives

2020 ◽  
Vol 12 (51) ◽  
pp. 57281-57289
Author(s):  
Liwen Hu ◽  
Zikang Chen ◽  
Yanshan Liu ◽  
Bishan Tian ◽  
Ting Guo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Two Photon
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