Orchestrating Cell/Material Interactions For Tissue Engineering of Surgical Implants

2012 ◽  
Vol 12 (8) ◽  
pp. 1010-1021 ◽  
Author(s):  
Achala de Mel ◽  
Alexander M. Seifalian ◽  
Martin A. Birchall
2011 ◽  
Vol 13 (12) ◽  
pp. B467-B475 ◽  
Author(s):  
Esther C. Novosel ◽  
Wolfdietrich Meyer ◽  
Nadine Klechowitz ◽  
Hartmut Krüger ◽  
Michael Wegener ◽  
...  

2014 ◽  
Vol 2 (44) ◽  
pp. 7795-7803 ◽  
Author(s):  
Baiwen Luo ◽  
Qiu Li Loh ◽  
Marcus Thien Chong Wong ◽  
Nguan Soon Tan ◽  
Cleo Choong

Lipoaspirate-derived extracellular matrix enrichment was able to provide the necessary cell adhesion receptors and biological factors for improving cell–material interactions of porous OVA microcarriers.


2018 ◽  
Author(s):  
Donata Iandolo ◽  
Fabrizio A. Pennacchio ◽  
Valentina Mollo ◽  
Domenico Rossi ◽  
David Dannhauser ◽  
...  

AbstractCell fate is largely determined by interactions that occur at the interface between cells and their surrounding microenvironment. For this reason, especially in the field of cell- and tissue-engineering, there is a growing interest in developing characterization techniques that allow a deep evaluation of cell-material interaction at the nanoscale, particularly focusing on cell adhesion processes. While for 2D culturing systems a consolidated series of tools already satisfy this need, in 3D environments, more closely recapitulating complex in vivo structures, there is still a lack of procedure furthering the comprehension of cell-material interactions. Here, we report for the first time the use of a SEM/FIB system for the characterization of cellular adhesion in 3D scaffolds fabricated by means of different techniques. Our results clearly show the capability of the developed approach to finely resolve both scaffold-cells interface and nanometer scale features of cell bodies involved in the upregulation of cellular behavior. These results are relevant for studying cellular guidance strategies and for the consequent design of more efficient cell-instructive platforms for tissue-engineering applications as well as for in vitro 3D models.


2018 ◽  
Vol 70 ◽  
pp. 1-11 ◽  
Author(s):  
Junxin Lin ◽  
Wenyan Zhou ◽  
Shan Han ◽  
Varitsara Bunpetch ◽  
Kun Zhao ◽  
...  

2012 ◽  
Vol 100A (7) ◽  
pp. 1907-1918 ◽  
Author(s):  
Elahe Masaeli ◽  
Mohammad Morshed ◽  
Parsa Rasekhian ◽  
Saeed Karbasi ◽  
Khadije Karbalaie ◽  
...  

2020 ◽  
Vol 8 (40) ◽  
pp. 9212-9226
Author(s):  
Kai Wu ◽  
Jing Sun ◽  
Yanzhe Ma ◽  
Dan Wei ◽  
Oscar Lee ◽  
...  

Photoisomerization and red-shifted photoswitching make azobenzene superior for exploring the cell-material interactions and designing tissue-engineering scaffolds.


2000 ◽  
Author(s):  
David L. Butler

Abstract Clinicians, biologists, and engineers face difficult challenges in engineering effective, cell-based composites for repair of orthopaedic and cardiovascular tissues. Whether repairing articular cartilage, bone, or blood vessel, the demands placed on the surgical implants can threaten the long-term success of the procedure. In 1998, the US National Committee on Biomechanics addressed this problem by suggesting a new paradigm for tissue engineering called “functional tissue engineering” or FTE. FTE seeks to address several important questions. What are the biomechanical demands placed upon the normal tissue and hence the tissue engineered implant after surgery? What parameters should a tissue engineer design into the implant before surgery? And what biomechanical parameters should the tissue engineer track to determine if the resulting repair is successful? To illustrate the principles, this presentation will discuss tendon repair as a model system for functional tissue engineering.


2012 ◽  
Vol 101A (6) ◽  
pp. 1778-1786 ◽  
Author(s):  
Tinneke Jacobs ◽  
Heidi Declercq ◽  
Nathalie De Geyter ◽  
Ria Cornelissen ◽  
Peter Dubruel ◽  
...  

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