Composite Nano-Titanium Oxide-Chitosan Artificial Skin Exhibits Strong Wound-Healing Effect-An Approach with Anti-Inflammatory and Bactericidal Kinetics

2007 ◽  
Vol 8 (4) ◽  
pp. 316-327 ◽  
Author(s):  
Chiung-Chi Peng ◽  
Ming-Hua Yang ◽  
Wen-Ta Chiu ◽  
Chun-Hung Chiu ◽  
Chi-Shen Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Titanium Oxide ◽  
Artificial Skin ◽  
Healing Effect ◽  
Wound Healing Effect ◽  
Anti Inflammatory

scholarly journals High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

2021 ◽  
Vol 7 (12) ◽  
pp. 1100
Author(s):  
Yasir Nazir ◽  
Pichchapa Linsaenkart ◽  
Chiranan Khantham ◽  
Tanakarn Chaitep ◽  
Pensak Jantrawut ◽  
...  
Keyword(s):  
Wound Healing ◽  
Interleukin 1 ◽  
Healing Process ◽  
Matrix Metalloproteinase 2 ◽  
Nucleotide Sequencing ◽  
Wound Healing Process ◽  
Healing Effect ◽  
Wound Healing Effect ◽  
Anti Inflammatory ◽  
Collagen Stimulation

Dictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and wound healing effect. The anti-inflammatory determination via the levels of cytokine releasing from macrophages, and the collagen stimulation activity on fibroblasts by matrix metalloproteinase-2 (MMP-2) inhibitory activity were determined to serve for the wound healing process promotion in the stage 2–4 (wound inflammation, proliferation, and remodelling of the skin). All D. indusiata extracts showed good antioxidant potential, significantly anti-inflammatory activity in the decreasing of the nitric oxide (NO), interleukin-1 (IL-1), interleukin-1 (IL-6), and tumour necrosis factor-α (TNF-α) secretion from macrophage cells (p < 0.05), and the effective collagen stimulation via MMP-2 inhibition. In particular, CW extract containing high content of catechin (68.761 ± 0.010 mg/g extract) which could significantly suppress NO secretion (0.06 ± 0.02 µmol/L) better than the standard anti-inflammatory drug diclofenac (0.12 ± 0.02 µmol/L) and their MMP-2 inhibition (41.33 ± 9.44%) was comparable to L-ascorbic acid (50.65 ± 2.53%). These findings support that CW of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.

The diabetic wound healing effect of a two-herb formula and its mechanisms of action

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
CBS Lau ◽  
VKM Lau ◽  
CL Liu ◽  
PKK Lai ◽  
JCW Tam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mechanisms Of Action ◽  
Diabetic Wound ◽  
Healing Effect ◽  
Diabetic Wound Healing ◽  
Wound Healing Effect

An in vivo Investigation on the Wound-Healing Effect of Two Medicinal Herbs Using an Animal Model with Foot Ulcer

2008 ◽  
Vol 41 (1) ◽  
pp. 15-23 ◽  
Author(s):  
T.W. Lau ◽  
D.S. Sahota ◽  
C.H. Lau ◽  
C.M. Chan ◽  
F.C. Lam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Foot Ulcer ◽  
Medicinal Herbs ◽  
Healing Effect ◽  
Wound Healing Effect

Wound-healing effect of ginsenoside Rd from leaves of Panax ginseng via cyclic AMP-dependent protein kinase pathway

2013 ◽  
Vol 702 (1-3) ◽  
pp. 285-293 ◽  
Author(s):  
Wang-Kyun Kim ◽  
Seung-Yong Song ◽  
Won Keun Oh ◽  
Sireewan Kaewsuwan ◽  
Tien Lam Tran ◽  
...  
Keyword(s):  
Wound Healing ◽  
Protein Kinase ◽  
Cyclic Amp ◽  
Panax Ginseng ◽  
Dependent Protein Kinase ◽  
Ginsenoside Rd ◽  
Healing Effect ◽  
Dependent Protein ◽  
Wound Healing Effect ◽  
Kinase Pathway

scholarly journals In silico Study of Trianthema portulacastrum Embedded Iron Oxide Nanoparticles on Glycogen Synthase Kinase-3β: A Possible Contributor to its Enhanced in vivo Wound Healing Potential

2021 ◽  
Vol 12 ◽  
Author(s):  
Ekta Yadav ◽  
Pankajkumar Yadav ◽  
Amita Verma
Keyword(s):  
Wound Healing ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Oxide Nanoparticles ◽  
Enzymatic Antioxidants ◽  
Glycogen Synthase Kinase 3Β ◽  
Hydroxyproline Content ◽  
Healing Effect ◽  
Trianthema Portulacastrum ◽  
Wound Healing Effect

Rich amount of phenolic compounds are available in Trianthema portulacastrum L. (TP) leaves and are traditionally utilized as a wound dressing material. Oxidative stress and inflammation affect the Wnt/β-catenin pathway by modulating the glycogen synthase kinase-3β (GSK) activity subjected to delay in wound healing. The objective of the current study was to explore the wound healing effect of ferric oxide nanoparticles biosynthesized with fractionated TP extract (FeTP). The ability of TP active components (polyphenols) to inhibit the GSK was explored by using molecular docking studies. FeTP were synthesized, characterized, utilized to prepare an ointment and its efficacy was investigated against full-thickness dermal wounds. Different wound healing parameters, level of enzymatic antioxidants, hydroxyproline content and tissue cytokines level were analyzed. Histopathology was performed to confirm the healing by newly formed tissue architecture. Rats treated with FeTP showed significantly swift healing with faster wound contraction rate, high tensile strength and hydroxyproline content along with the utilization of less time for epithelialization. Histopathological study also validated the potential wound healing effect of FeTP with complete re-epithelialization. The results of the present study cumulatively revealed that the green synthesized FeTP ointment approach may serve as a potential tool for dermal wound healing.

scholarly journals Role of hyaluronic acid based hydrogel in management of wound healing effect

2019 ◽  
Vol 4 (6) ◽  
pp. 152-160
Author(s):  
Kiran Baviskar ◽  
Tanvir Shaikh ◽  
Kiran D. Patil ◽  
Rahul Baviskar ◽  
Santram Lodhi
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Healing Effect ◽  
Wound Healing Effect
Sign in / Sign up

Export Citation Format

Share Document