Water-Soluble pH-Responsive Dendritic Core-Shell Nanocarriers for Polar Dyes Based on Poly(ethylene imine)

2007 ◽  
Vol 7 (8) ◽  
pp. 968-974 ◽  
Author(s):  
Shangjie Xu ◽  
Ying Luo ◽  
Rainer Haag
Keyword(s):  
Water Soluble ◽  
Core Shell ◽  
Ph Responsive ◽  
Ethylene Imine ◽  
Dendritic Core ◽  
Poly Ethylene

pH-Responsive dendritic core-shell architectures as amphiphilic nanocarriers for polar drugs

2006 ◽  
Vol 14 (6) ◽  
pp. 367-374 ◽  
Author(s):  
Shangjie Xu ◽  
Michael Krämer ◽  
Rainer Haag
Keyword(s):  
Core Shell ◽  
Ph Responsive ◽  
Dendritic Core ◽  
Polar Drugs

In situ crosslinked PVA–PEI polymer binder for long-cycle silicon anodes in Li-ion batteries

RSC Advances ◽  
2016 ◽  
Vol 6 (72) ◽  
pp. 68371-68378 ◽  
Author(s):  
Zhen Liu ◽  
Shaojie Han ◽  
Chong Xu ◽  
Yuwen Luo ◽  
Na Peng ◽  
...  
Keyword(s):  
Polymer Binder ◽  
Water Soluble ◽  
Silicon Anode ◽  
Cross Linking ◽  
Li Ion Batteries ◽  
Ethylene Imine ◽  
Silicon Anodes ◽  
Li Ion ◽  
Poly Ethylene

A novel polymer binder, synthesized via in situ thermal cross-linking of water-soluble polyvinyl alcohol (PVA) and poly(ethylene imine) (PEI) precursor, is applied as a functional network binder to enhance the electrochemical performance of a silicon anode.

pH-Responsive Molecular Nanocarriers Based on Dendritic Core-Shell Architectures

2002 ◽  
Vol 41 (22) ◽  
pp. 4252-4256 ◽  
Author(s):  
Michael Krämer ◽  
Jean-François Stumbé ◽  
Holger Türk ◽  
Simon Krause ◽  
Ansgar Komp ◽  
...  
Keyword(s):  
Core Shell ◽  
Ph Responsive ◽  
Dendritic Core

scholarly journals Effect of pH-Responsive Charge-Conversional Polymer Coating to Cationic Reduced Graphene Oxide Nanostructures for Tumor Microenvironment-Targeted Drug Delivery Systems

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1289 ◽  
Author(s):  
Kitae Ryu ◽  
Jaehong Park ◽  
Tae-il Kim
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethylene Imine ◽  
Serum Stability ◽  
Reduced Graphene ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Targeted Drug Delivery Systems

Tumor tissue represents a slightly acidic pH condition compared to normal tissue due to the accumulation of lactic acids via anaerobic metabolism. In this work, pH-responsive charge-conversional polymer (poly(ethylene imine)-poly(l-lysine)-poly(l-glutamic acid), PKE polymer) was employed for endowing charge-conversional property and serum stability to poly(ethylene imine) conjugated reduced graphene oxide-based drug delivery system (PEI-rGO). Zeta-potential value of PEI-rGO coated with PK5E7 polymer (PK5E7(PEI-rGO)) was −10.9 mV at pH 7.4 and converted to 29.2 mV at pH 6.0, showing pH-responsive charge-conversional property. Sharp-edged plate morphology of PEI-rGO was transformed to spherical nanostructures with vague edges by PK5E7 coating. Size of PK5E7(PEI-rGO) was found to be smaller than that of PEI-rGO in the serum condition, showing its increased serum stability. Loaded doxorubicin (DOX) in PK5E7(PEI-rGO) could be released rapidly in lysosomal condition (pH 5.0, 5 mM glutathione). Furthermore, DOX-loaded PK5E7(PEI-rGO) showed enhanced anticancer activity in HeLa and A549 cells in the tumor microenvironment-mimicking condition (pH 6.0, serum), which would be mediated by non-specific cellular interaction with decorated serum proteins. These results indicate that the pH-responsive charge-conversional PKE polymer coating strategy of cationic rGO nanostructures possesses a potential for acidic tumor microenvironment-targeted drug delivery systems.

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