scholarly journals Interleukin-2 and interleukin-12 mediate distinct effector mechanisms of liver allograft rejection

1997 ◽  
Vol 3 (2) ◽  
pp. 118-129 ◽  
Author(s):  
N L Thai ◽  
Y Li ◽  
F Fu ◽  
S Qian ◽  
A J Demetris ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Interleukin 2 ◽  
Interleukin 12 ◽  
Liver Allograft ◽  
Effector Mechanisms

Increased expression of non-interleukin-2 T cell growth factors and their implications during liver allograft rejection in rats

2007 ◽  
Vol 22 (7) ◽  
pp. 1141-1147 ◽  
Author(s):  
Wei-Lin Wang ◽  
Min-Ya Yao ◽  
Jing Jin ◽  
Chang-Ku Jia ◽  
Liang-Hui Gao ◽  
...  
Keyword(s):  
Growth Factors ◽  
T Cell ◽  
Cell Growth ◽  
Allograft Rejection ◽  
Interleukin 2 ◽  
Liver Allograft ◽  
T Cell Growth

SOLUBLE INTERLEUKIN-2 RECEPTOR LEVEL AS AN INDICATOR OF LIVER ALLOGRAFT REJECTION

1989 ◽  
Vol 47 (1) ◽  
pp. 77-81 ◽  
Author(s):  
James D. Perkins ◽  
David L. Nelson ◽  
Jorge Rakela ◽  
Patricia M. Grambsch ◽  
Ruud A. F. Krom
Keyword(s):  
Allograft Rejection ◽  
Interleukin 2 ◽  
Liver Allograft ◽  
Receptor Level ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor

scholarly journals Bone Marrow Allograft Rejection Mediated by a Novel Murine NK Receptor, NKG2I

2004 ◽  
Vol 199 (1) ◽  
pp. 137-144 ◽  
Author(s):  
Junzo Koike ◽  
Hiroshi Wakao ◽  
Yuko Ishizuka ◽  
Taka-aki Sato ◽  
Masaru Hamaoki ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Nk Cells ◽  
Allograft Rejection ◽  
Molecular Mechanisms ◽  
Interleukin 2 ◽  
Flow Cytometric Analysis ◽  
Interleukin 12 ◽  
Target Cells ◽  
Allogeneic Bone ◽  
Nk Receptor

Natural killer (NK) cells mediate bone marrow allograft rejection. However, the molecular mechanisms underlying such a rejection remain elusive. In previous analyses, it has been shown that NK cells recognize allogeneic target cells through Ly-49s and CD94/NKG2 heterodimers. Here, we describe identification and characterization of a novel murine NK receptor, NKG2I, belonging to the NKG2 family. NKG2I, which was composed of 226 amino acids, showed ∼40% homology to the murine NKG2D and CD94 in the C-type lectin domain. Flow cytometric analysis with anti-NKG2I monoclonal antibody (mAb) revealed that expression of NKG2I was largely confined to NK and NKT cells, but was not seen in T cells. Furthermore, anti-NKG2I mAb inhibited NK cell–mediated cytotoxicity, whereas cross-linking of NKG2I enhanced interleukin 2– and interleukin 12–dependent interferon-γ production. Similarly, the injection of anti-NKG2I mAb before the allogeneic bone marrow transfer in vivo impinged on the function of NKG2I, resulting in the enhanced colony formation in the spleen. NKG2I is a novel activating receptor mediating recognition and rejection of allogeneic target cells.

Patterns of Liver Allograft Rejection

2021 ◽  
pp. 353-359
Author(s):  
Geoffrey W. McCaughan ◽  
Ken Liu ◽  
Avik Majumdar ◽  
Patrick Bertolino ◽  
David G. Bowen ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Liver Allograft

Effector mechanisms in allograft rejection

1977 ◽  
Vol 30 (2) ◽  
pp. 236-253 ◽  
Author(s):  
P.J. Roberts ◽  
P. Häyry
Keyword(s):  
Allograft Rejection ◽  
Effector Mechanisms

Mouse liver allograft rejection correlates with enhanced TH1 function

1994 ◽  
Vol 40 ◽  
pp. 56
Author(s):  
N.L. Thai ◽  
L. Gao ◽  
H. Sun ◽  
F. Fu ◽  
S. Qian ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Mouse Liver ◽  
Liver Allograft

Liver Allograft Rejection : An Analysis of the Use of Biopsy in Determining Outcome of Rejection

1987 ◽  
Vol 11 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Dale C. Snover ◽  
Deborah K. Freese ◽  
Harvey L. Sharp ◽  
Joseph R. Bloomer ◽  
John S. Najarian ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Liver Allograft
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