Temporal Trends and Evolving Outcomes after Simultaneous Liver‐Kidney Transplant (SLKT): Results from the United States SLKT Consortium

2021 ◽  
Author(s):  
Giuseppe Cullaro ◽  
Pratima Sharma ◽  
Jennifer Jo ◽  
Jasmine Rassiwala ◽  
Lisa VanWagner ◽  
...  
Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0005282021
Author(s):  
Xingxing S. Cheng ◽  
Sai Liu ◽  
Jialin Han ◽  
Margaret R. Stedman ◽  
Glenn M. Chertow ◽  
...  

Background: Coronary artery disease (CAD) screening in asymptomatic kidney transplant candidates is widespread but not well supported by contemporary cardiology literature. We describe here temporal trends in CAD screening before kidney transplant in the United States. Methods: Using the United States Renal Data System, we examined Medicare-insured adults who received a first kidney transplant from 2000 through 2015. We stratified analysis based on whether the patient's comorbidity burden met guideline definitions of high-risk for CAD. We examined temporal trends in non-urgent CAD tests within the year prior to transplant and the composite of death and non-fatal myocardial infarction in the 30 days after transplant. Results: Of 94,832 kidney transplant recipients, 37,139 (39%) underwent at least one non-urgent CAD test in the 1 year prior to transplant. From 2000 to 2015, The transplant program waitlist volume had increased as transplant volume stayed constant, while patients in the later eras had slightly higher comorbidity burden (older, longer dialysis vintage, and a higher prevalence of diabetes mellitus and CAD). The likelihood of CAD test in the year prior to transplant increased from 2000 through 2003 and remained relatively stable thereafter. When stratified by CAD risk status, test rates decreased modestly in high-risk patients but remained constant in low-risk patients after 2008. Death or non-fatal myocardial infarction within 30 days after transplant decreased from 3.4% in 2000 to 1.5% in 2015. Nuclear perfusion scan was the most frequent modality of testing throughout examined time periods. Conclusions: CAD testing rates before kidney transplantation have remained constant from 2000 through 2015 despite widespread changes in cardiology guidelines and practice.


2021 ◽  
Author(s):  
Geeta Karadkhele ◽  
Charlotte Duneton ◽  
Rouba Garro ◽  
Idelberto Raul Badell ◽  
Thomas C. Pearson ◽  
...  

2020 ◽  
Vol 95 (12) ◽  
pp. 2665-2673
Author(s):  
Akram Kawsara ◽  
Samian Sulaiman ◽  
Jane Linderbaum ◽  
Sarah R. Coffey ◽  
Fahad Alqahtani ◽  
...  

Author(s):  
Sarah L. Jackson ◽  
Sahar Derakhshan ◽  
Leah Blackwood ◽  
Logan Lee ◽  
Qian Huang ◽  
...  

This paper examines the spatial and temporal trends in county-level COVID-19 cases and fatalities in the United States during the first year of the pandemic (January 2020–January 2021). Statistical and geospatial analyses highlight greater impacts in the Great Plains, Southwestern and Southern regions based on cases and fatalities per 100,000 population. Significant case and fatality spatial clusters were most prevalent between November 2020 and January 2021. Distinct urban–rural differences in COVID-19 experiences uncovered higher rural cases and fatalities per 100,000 population and fewer government mitigation actions enacted in rural counties. High levels of social vulnerability and the absence of mitigation policies were significantly associated with higher fatalities, while existing community resilience had more influential spatial explanatory power. Using differences in percentage unemployment changes between 2019 and 2020 as a proxy for pre-emergent recovery revealed urban counties were hit harder in the early months of the pandemic, corresponding with imposed government mitigation policies. This longitudinal, place-based study confirms some early urban–rural patterns initially observed in the pandemic, as well as the disparate COVID-19 experiences among socially vulnerable populations. The results are critical in identifying geographic disparities in COVID-19 exposures and outcomes and providing the evidentiary basis for targeting pandemic recovery.


2013 ◽  
Vol 166 (2) ◽  
pp. 273-281.e4 ◽  
Author(s):  
Sunil V. Rao ◽  
Connie N. Hess ◽  
David Dai ◽  
Cynthia L. Green ◽  
Eric D. Peterson ◽  
...  

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