scholarly journals Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand

2019 ◽  
Vol 25 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Luis Calzadilla‐Bertot ◽  
Gary P. Jeffrey ◽  
Bryon Jacques ◽  
Geoffrey McCaughan ◽  
Michael Crawford ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
New Zealand ◽  
Nonalcoholic Steatohepatitis

scholarly journals Vaginal varices with massive hemorrhage in a patient with nonalcoholic steatohepatitis and portal hypertension: Successful treatment with liver transplantation

2008 ◽  
Vol 14 (10) ◽  
pp. 1538-1540 ◽  
Author(s):  
Patrick P. McHugh ◽  
Hoonbae Jeon ◽  
Roberto Gedaly ◽  
Thomas D. Johnston ◽  
Paul D. DePriest ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Portal Hypertension ◽  
Successful Treatment ◽  
Nonalcoholic Steatohepatitis ◽  
Massive Hemorrhage

scholarly journals The role of extended criteria donors in liver transplantation for nonalcoholic steatohepatitis

Surgery ◽  
2016 ◽  
Vol 160 (6) ◽  
pp. 1533-1543 ◽  
Author(s):  
Francesca M. Dimou ◽  
Hemalkumar B. Mehta ◽  
Deepak Adhikari ◽  
Robert C. Harland ◽  
Taylor S. Riall ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Nonalcoholic Steatohepatitis ◽  
Extended Criteria Donors

Both Alcoholic and Nonalcoholic Steatohepatitis Is an Emerging Indication for Liver Transplantation in the United States

2020 ◽  
Vol 04 (02) ◽  
pp. 223-234
Author(s):  
Danielle Fritze ◽  
Amandeep Singh ◽  
Eric Lawitz ◽  
Kris V. Kowdley ◽  
Glenn Halff ◽  
...  
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Nonalcoholic Steatohepatitis ◽  
Multivariable Analysis ◽  
Deceased Donor ◽  
The United States ◽  
Hispanic Males ◽  
Patient And Graft Survival ◽  
United Network

Abstract Background Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease (ALD) are now the most common indications for liver transplantation (LT) in the United States. A subset of patients have both alcoholic and nonalcoholic steatohepatitis (BASH). This study characterizes patients with BASH requiring LT and assesses changes in the prevalence of BASH as an indication for LT. Methods The United Network for Organ Sharing database was analyzed for all patients ≥ 18 years of age who received their first deceased donor LT from 2002 to 2016 for ALD, NASH, or BASH. Baseline demographics, clinical parameters, and LT outcomes were compared between groups. Results Since 2002, 85,448 patients underwent LT:15,327 had ALD, 9,971 had NASH, and 2,779 had BASH. The prevalence of BASH as an indication for LT increased from 0.5% in 2002 to 5% in 2016. Compared with patients with NASH, those with BASH were significantly more likely to be male (85.6 vs. 57%), younger (mean 56.4 vs. 58.6 years), and Hispanic (22.2 vs. 13.6%) (p < 0.001 for all). While indication for transplant was not significantly associated with transplant outcomes on multivariable analysis, patient and graft survival curves do differ significantly by indication for transplant, with worse outcomes for patients with BASH (patient survival at 5 years: NASH 78.1%, ALD 77.2%, BASH 73.5%, p = 0.013; graft survival at 5 years: NASH 75.3%, ALD 74.0%, BASH 70.8%, p = 0.046). Conclusions BASH is a rising indication for LT, especially for Hispanic males, due to the increasing prevalence of ALD and NASH in the United States.

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

2015 ◽  
Vol 148 (3) ◽  
pp. 547-555 ◽  
Author(s):  
Robert J. Wong ◽  
Maria Aguilar ◽  
Ramsey Cheung ◽  
Ryan B. Perumpail ◽  
Stephen A. Harrison ◽  
...  
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Liver Disease ◽  
Nonalcoholic Steatohepatitis ◽  
The United States
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