scholarly journals Prerecovery liver biopsy in the brain-dead donor: A case-control study of logistics, safety, precision, and utility

2014 ◽  
Vol 20 (2) ◽  
pp. 237-244 ◽  
Author(s):  
Joseph Benton Oliver ◽  
Stephen Peters ◽  
Advaith Bongu ◽  
Abdel-Kareem Beidas ◽  
George Dikdan ◽  
...  
1983 ◽  
Vol 2 (3-4) ◽  
pp. 179-195 ◽  
Author(s):  
Sanford S. Leffingwell ◽  
Richard Waxweiler ◽  
Victor Alexander ◽  
Howard R. Ludwig ◽  
William Halperin

2020 ◽  
Vol 52 (2) ◽  
pp. 636-637
Author(s):  
Joachim Forget ◽  
Polona Pozeg ◽  
Reto A. Meuli ◽  
Philippe Maeder

2020 ◽  
Vol 52 (2) ◽  
pp. 634-635 ◽  
Author(s):  
Elif Dilara Topcuoglu ◽  
Osman Melih Topcuoglu ◽  
Aslıhan Semiz Oysu ◽  
Yasar Bukte

2004 ◽  
Vol 185 (2) ◽  
pp. 169-170 ◽  
Author(s):  
Jeremy Hall ◽  
Jonathan M. Harris ◽  
Reiner Sprengelmeyer ◽  
Anke Sprengelmeyer ◽  
Andrew W. Young ◽  
...  

SummaryStudies of face processing have begun to elucidate the brain regions involved in social cognition, which include frontal and temporal regions known to be reduced in volume in schizophrenia. In this case-control study participants with schizophrenia (n=20) showed marked deficits in their ability to interpret social cues from faces, and those experiencing positive symptoms were impaired in recognising even basic facial emotions.


PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11384
Author(s):  
Ya Luo ◽  
Weihong Xu ◽  
Wei Ou ◽  
Ting Wang ◽  
Changwei Yang ◽  
...  

Objectives The aim of this work is to explore the association between chronic exposure to nonylphenol (NP), a representative environmental endocrine disruptor (EED), and the risk of depression and its potential mechanism. Methods A hospital-based case control study was conducted from August to December 2018. Forty-one patients with confirmed depression and 47 healthy volunteers were recruited. In vitro, 20 rats were randomly divided into the control group (corn oil) and NP exposure group (n = 10 per group), which were gavaged at a dose of 4 mg/kg w/day for 180 days. Results The depressed patient group had higher Zung Self-Rating Depression Scale (SDS) (P < 0.001) and Self-Rating Anxiety Scale (SAS) (P < 0.001) scores than the healthy group. The serum NP level (P = 0.009) in the depressed group was higher than that in the healthy group, and the BDNF level (P = 0.001) was lower. The serum levels of monoamine neurotransmitters dopamine (DA) (P = 0.070), epinephrine (E) (P = 0.001), and noradrenaline (NE) (P = 0.000) were lower than those in the healthy group. In the sucrose preference test, the sucrose preference time for the exposure group of rats was lower than that of the control group (P < 0.001). In the forced swim test, a longer resting time was measured for the exposure group of rats as compared to the control group (P < 0.05). The level of NP (P < 0.001) in the brain tissue of the NP exposure group was higher than that in the control group, and the serum level of brain-derived neurotrophic factor (BDNF) (P = 0.004) was lower. Histopathological examination of the brain biopsies illustrated that the neuronal cells and nuclei in the hippocampus of the exposed group exhibited slight shrinkage. Conclusion Chronic exposure to NP at environmental doses will result in the accumulation of NP in the brain and blood, and induction of depression, which might be associated with the alterations in the expression levels of BDNF and monoamine neurotransmitters.


2013 ◽  
Vol 169 (6) ◽  
pp. 811-819 ◽  
Author(s):  
Cornelie D Andela ◽  
Steven J A van der Werff ◽  
J Nienke Pannekoek ◽  
Susan M van den Berg ◽  
Onno C Meijer ◽  
...  

ObjectivePatients with long-term remission of Cushing's disease (CD) have persistent psychological and cognitive impairments. It is unknown whether, and to what extent, these impairments are accompanied by structural abnormalities in the brain. We aim to investigate structural changes in the brain in patients with predominantly long-term remission of CD and to examine whether these changes are associated with psychological and cognitive dysfunction and clinical severity.DesignA cross-sectional, case–control study.MethodsIn 25 patients with predominantly long-term remission of CD and 25 matched healthy controls, grey matter volumes in the regions of interest (hippocampus, amygdala, and anterior cingulate cortex (ACC)) and in the whole brain were examined, using 3T magnetic resonance imaging and a voxel-based morphometry approach. Psychological and cognitive functioning were assessed using validated questionnaires and clinical severity was assessed using the Cushing's syndrome severity index.ResultsCompared with controls, patients had smaller grey matter volumes of areas in the ACC (on average 14%, P<0.05) and greater volume of the left posterior lobe of the cerebellum (on average 34%, P<0.05). As expected, patients with remitted CD reported more depressive symptoms (P=0.005), more anxiety (P=0.003), more social phobia (P=0.034), more apathy (P=0.002), and more cognitive failure (P=0.023) compared with controls, but the differences in grey matter volumes were not associated with psychological or cognitive measures, nor with clinical severity.ConclusionPatients with predominantly long-term remission of CD showed specific structural brain abnormalities, in the presence of psychological dysfunction. Our data form a basis for future work aimed at elucidating the relation of the structural brain abnormalities and the sustained psychological deficits after long-term exposure to high cortisol levels.


2019 ◽  
Vol 51 (5) ◽  
pp. 1471-1477 ◽  
Author(s):  
Elif Dilara Topcuoglu ◽  
Osman Melih Topcuoglu ◽  
Aslihan Semiz Oysu ◽  
Yasar Bukte

2014 ◽  
Vol 98 ◽  
pp. 183 ◽  
Author(s):  
J. Oliver ◽  
P. Machineni ◽  
A. Bongu ◽  
J. Nespral ◽  
C. Kadric ◽  
...  

2017 ◽  
Vol 61 (1) ◽  
pp. 145-155 ◽  
Author(s):  
Nagato Kuriyama ◽  
Etsuko Ozaki ◽  
Toshiki Mizuno ◽  
Masafumi Ihara ◽  
Shigeto Mizuno ◽  
...  

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