scholarly journals Improved renal function in liver transplant recipients treated for hepatitis C virus with a sustained virological response and mild chronic kidney disease

2013 ◽  
Vol 20 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Michel Blé ◽  
Victoria Aguilera ◽  
Angel Rubín ◽  
María García‐Eliz ◽  
Carmen Vinaixa ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Kidney Disease ◽  
Liver Transplant ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Achieving Sustained Virological Response in Liver Transplant Recipients With Hepatitis C Decreases Risk of Decline in Renal Function

2018 ◽  
Vol 24 (8) ◽  
pp. 1040-1049 ◽  
Author(s):  
Sanjaya K. Satapathy ◽  
Kiran Joglekar ◽  
Miklos Z. Molnar ◽  
Bilal Ali ◽  
Humberto C. Gonzalez ◽  
...  
Keyword(s):  
Renal Function ◽  
Hepatitis C ◽  
Liver Transplant ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C

2014 ◽  
Vol 46 (5) ◽  
pp. 440-445 ◽  
Author(s):  
Francesca Romana Ponziani ◽  
Raffaella Viganò ◽  
Rosa Maria Iemmolo ◽  
Maria Francesca Donato ◽  
Maria Rendina ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Liver Transplant ◽  
Sustained Virological Response ◽  
Virological Response ◽  
Transplant Recipients ◽  
Recurrent Hepatitis ◽  
Recurrent Hepatitis C ◽  
Liver Transplant Recipients ◽  
Term Maintenance

scholarly journals Renal Function Improvement by Telbivudine in Liver Transplant Recipients with Chronic Kidney Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Wei-Chen Lee ◽  
Tsung-Han Wu ◽  
Yu-Chao Wang ◽  
Chih-Hsien Cheng ◽  
Chen-Fang Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Liver Transplant ◽  
Continuous Group ◽  
Transplant Recipients ◽  
Lamivudine Prophylaxis ◽  
Additional Value ◽  
Post Hoc ◽  
Liver Transplant Recipients

Chronic renal failure is a frequent complication in liver transplantation. Telbivudine, anti-hepatitis B virus (HBV) nucleoside, can improve renal function. It is interesting if using telbivudine for prophylaxis of HBV recurrence has additional value on renal function improvement. 120 liver transplant recipients with lamivudine prophylaxis for HBV recurrence were 1 : 1 randomized into lamivudine-continuous (n=60) and telbivudine-replacement (n=60) groups. Fifty-eight patients in lamivudine-continuous group and 54 in telbivudine-replacement group completed the study. In telbivudine-replacement group, the estimated glomerular filtration rate (eGRF) was improved from 63.0 ± 16.3 ml/min to 72.8 ± 21.1 ml/min at 12 months after telbivudine administration (p = 0.003). Stratifying the patients according to renal function staging, the eGRF was improved from 74.7 ± 6.9 ml/min to 84.2 ± 16.6 ml/min (p = 0.002) in 32 stage II patients and from 48.2 ± 7.3 ml/min to 59.7 ± 11.8 ml/min in 20 stage III patients after 12 months of telbivudine administration (p<0.001). Eleven (18.3%) patients with telbivudine developed polyneuritis during the trial and post hoc following-up. In conclusion, renal function was improved by telbivudine in liver transplant recipients with long-term chronic kidney disease. However, the high incidence of polyneuritis induced by telbivudine has to be closely monitored. This trial is registered with ClinicalTrials NCT02447705.

Sign in / Sign up

Export Citation Format

Share Document