Mobilization of hepatic mesenchymal stem cells from human liver grafts

2011 ◽  
Vol 17 (5) ◽  
pp. 596-609 ◽  
Author(s):  
Qiuwei Pan ◽  
Suomi M. G. Fouraschen ◽  
Fatima S. F. Aerts Kaya ◽  
Monique M. Verstegen ◽  
Mario Pescatori ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Liver

Characterization of mesenchymal stem cells-like in human liver

2008 ◽  
Vol 40 (5) ◽  
pp. A14
Author(s):  
R. Ratti ◽  
N. Saulnier ◽  
F. Colombo ◽  
L. Porretti ◽  
A. Cattaneo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Liver

scholarly journals Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope?

Cells ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 1127 ◽  
Author(s):  
Irina V. Kholodenko ◽  
Leonid K. Kurbatov ◽  
Roman V. Kholodenko ◽  
Garik V. Manukyan ◽  
Konstantin N. Yarygin
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Progenitor Cells ◽  
Liver Tissue ◽  
Liver Diseases ◽  
Human Liver ◽  
Chronic Liver ◽  
Attractive Alternative ◽  
Short Supply

Chronic liver diseases constitute a significant economic, social, and biomedical burden. Among commonly adopted approaches, only organ transplantation can radically help patients with end-stage liver pathologies. Cell therapy with hepatocytes as a treatment for chronic liver disease has demonstrated promising results. However, quality human hepatocytes are in short supply. Stem/progenitor cells capable of differentiating into functionally active hepatocytes provide an attractive alternative approach to cell therapy for liver diseases, as well as to liver-tissue engineering, drug screening, and basic research. The application of methods generally used to isolate mesenchymal stem cells (MSCs) and maintain them in culture to human liver tissue provides cells, designated here as liver MSCs. They have much in common with MSCs from other tissues, but differ in two aspects—expression of a range of hepatocyte-specific genes and, possibly, inherent commitment to hepatogenic differentiation. The aim of this review is to analyze data regarding liver MSCs, probably another type of liver stem/progenitor cells different from hepatic stellate cells or so-called hepatic progenitor cells. The review presents an analysis of the phenotypic characteristics of liver MSCs, their differentiation and therapeutic potential, methods for isolating these cells from human liver, and discusses issues of their origin and heterogeneity. Human liver MSCs are a fascinating object of fundamental research with a potential for important practical applications.

Placenta-derived mesenchymal stem cells enhance human liver organoid maturation: translational implications for liver regeneration

Cytotherapy ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. S96-S97
Author(s):  
V. Miceli ◽  
A. Lo Nigro ◽  
M. Pampalone ◽  
G. Vitale ◽  
P. Conaldi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Regeneration ◽  
Human Liver

scholarly journals Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases

2010 ◽  
Vol 8 (1) ◽  
pp. 19-22 ◽  
Author(s):  
Hu Lin ◽  
Ruonan Xu ◽  
Zheng Zhang ◽  
Liming Chen ◽  
Ming Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Diseases ◽  
Human Liver

Secreted Factors of Human Liver-Derived Mesenchymal Stem Cells Promote Liver Regeneration Early After Partial Hepatectomy

2012 ◽  
Vol 21 (13) ◽  
pp. 2410-2419 ◽  
Author(s):  
Suomi M.G. Fouraschen ◽  
Qiuwei Pan ◽  
Petra E. de Ruiter ◽  
Waqar R.R. Farid ◽  
Geert Kazemier ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Human Liver ◽  
Secreted Factors

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm

2010 ◽  
Vol 30 (6) ◽  
pp. 455-455 ◽  
Author(s):  
Dongyan Shi ◽  
Dan Ma ◽  
Feiqing Dong ◽  
Chen Zong ◽  
Liyue Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells
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