scholarly journals Outcome of liver transplantation for drug-induced acute liver failure in the United States: Analysis of the united network for organ sharing database

2009 ◽  
Vol 15 (7) ◽  
pp. 719-729 ◽  
Author(s):  
Ayse L. Mindikoglu ◽  
Laurence S. Magder ◽  
Arie Regev
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
The United States ◽  
Drug Induced ◽  
United Network

scholarly journals Liver transplantation for acute liver failure from drug induced liver injury in the United States

2004 ◽  
Vol 10 (8) ◽  
pp. 1018-1023 ◽  
Author(s):  
Mark W. Russo ◽  
Joseph A. Galanko ◽  
Roshan Shrestha ◽  
Michael W. Fried ◽  
Paul Watkins
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
The United States ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Etiology and Outcome of Acute Liver Failure: Experience from a Liver Transplantation Centre in Montreal

2002 ◽  
Vol 16 (10) ◽  
pp. 672-676 ◽  
Author(s):  
Geneviève Tessier ◽  
Edith Villeneuve ◽  
Jean-Pierre Villeneuve
Keyword(s):  
Liver Transplantation ◽  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Rapid Development ◽  
Significant Proportion ◽  
Rare Condition ◽  
Unknown Origin ◽  
The United States ◽  
Drug Induced

BACKGROUND: Acute liver failure is a rare condition in which massive liver injury is associated with the rapid development of hepatic encephalopathy. Although viral hepatitis and drug-induced liver injury are the most common causes, no specific etiology is found in a substantial proportion of cases reported from Europe and the United States.AIM: To determine the etiology and outcome of patients with acute liver failure in the authors’ institution.PATIENTS AND METHODS: The charts of 81 consecutive patients admitted to Saint-Luc between 1991 and 1999 were reviewed.RESULTS: The etiology was viral in 27 cases (33.2%), toxic or drug-induced in 22 (27.2%), of unknown origin in 22 (27.2%) and due to various causes in 10 (12.3%) (autoimmune, vascular, cancer). Of the 81 patients, 16% survived without liver transplantation, and 84% died or underwent liver transplantation. Survival without liver transplantation differed according to the mode of presentation: the survival rate was 27% in patients with hyperacute liver failure, 7% in those with acute liver failure and 0% in those with subacute liver failure. Among the 38 patients who underwent liver transplantation, survival one year after transplantation was 71%. In the 30 patients who died without liver transplantation, the main causes of death were cerebral edema and sepsis.CONCLUSIONS: Acute liver failure is associated with a high mortality, and liver transplantation is the treatment of choice. In a significant proportion of cases, the etiology remains undetermined and is probably related to yet unidentified hepatotropic viruses.

Gender Differences in Acute Liver Failure in Patients Waitlisted for Liver Transplantation in the United States

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S475-S476
Author(s):  
Zahra Zia ◽  
Marwan Ghabril ◽  
Eric Orman ◽  
Naga Chalasani ◽  
Lauren Nephew
Keyword(s):  
United States ◽  
Gender Differences ◽  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
The United States

scholarly journals Determinants of outcome among patients with acute liver failure listed for liver transplantation in the United States

2016 ◽  
Vol 22 (4) ◽  
pp. 505-515 ◽  
Author(s):  
K. Rajender Reddy ◽  
Caitlyn Ellerbe ◽  
Michael Schilsky ◽  
R. Todd Stravitz ◽  
Robert J. Fontana ◽  
...  
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
The United States

Acute Liver Failure

2016 ◽  
Vol 31 (10) ◽  
pp. 642-653 ◽  
Author(s):  
Carmi S. Punzalan ◽  
Curtis T. Barry
Keyword(s):  
Liver Transplantation ◽  
Hepatic Encephalopathy ◽  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Specific Treatment ◽  
The United States ◽  
Drug Induced ◽  
Life Threatening ◽  
Transplantation Center

Acute liver failure is life threatening liver injury with coagulopathy and hepatic encephalopathy within 26 weeks and generally, in the absence of preexisting liver disease. Fulminant liver failure occurs when hepatic encephalopathy occurs within 8 weeks of jaundice. The majority of patients with ALF are women with the median age of 38 years. In the United States, drug induced liver injury including acetaminophen causes the majority of ALF cases. The etiology of ALF should be determined, if possible, because many causes have a specific treatment. The mainstay for ALF is supportive care and liver transplantation, if necessary. There are multiple prognostic criteria available. Prognosis can be poor and patients should be referred to a liver transplantation center as soon as possible.

scholarly journals Valproic Acid-Associated Acute Liver Failure in Children: Case Report and Analysis of Liver Transplantation Outcomes in the United States

2011 ◽  
Vol 158 (5) ◽  
pp. 802-807 ◽  
Author(s):  
Ayse L. Mindikoglu ◽  
Dale King ◽  
Laurence S. Magder ◽  
John A. Ozolek ◽  
George V. Mazariegos ◽  
...  
Keyword(s):  
United States ◽  
Valproic Acid ◽  
Liver Transplantation ◽  
Case Report ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
The United States ◽  
Transplantation Outcomes

scholarly journals Drug-Induced Autoimmune Hepatitis From Hydralazine Leading to Acute Liver Failure and Liver Transplantation

2019 ◽  
Vol 6 (10) ◽  
pp. e00252 ◽  
Author(s):  
Jasleen Grewal ◽  
Angela Doan ◽  
Annie S. Hong ◽  
Arpit Amin ◽  
Jason V. Scapa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Autoimmune Hepatitis ◽  
Drug Induced
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