scholarly journals Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction

2006 ◽  
Vol 12 (4) ◽  
pp. 636-643 ◽  
Author(s):  
Shaun P. Cordoba ◽  
Chuanmin Wang ◽  
Rohan Williams ◽  
Jian Li ◽  
Lynn Smit ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Rat Model ◽  
Gene Array ◽  
Tolerance Induction ◽  
Complement C3 ◽  
Array Analysis ◽  
Transplant Tolerance ◽  
Gene Array Analysis

scholarly journals Liver Transplant Tolerance and Its Application to the Clinic: Can We Exploit the High Dose Effect?

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Eithne C. Cunningham ◽  
Alexandra F. Sharland ◽  
G. Alex Bishop
Keyword(s):  
Liver Transplant ◽  
Tolerance Induction ◽  
Experimental Models ◽  
Dose Effect ◽  
Liver Graft ◽  
High Dose ◽  
Transplant Tolerance ◽  
Tissue Mass ◽  
Mhc Molecules ◽  
Specific Tolerance

The tolerogenic properties of the liver have long been recognised, especially in regard to transplantation. Spontaneous acceptance of liver grafts occurs in a number of experimental models and also in a proportion of clinical transplant recipients. Liver graft acceptance results from donor antigen-specific tolerance, demonstrated by the extension of tolerance to other grafts of donor origin. A number of factors have been proposed to be involved in liver transplant tolerance induction, including the release of soluble major histocompatibility (MHC) molecules from the liver, its complement of immunosuppressive donor leucocytes, and the ability of hepatocytes to directly interact with and destroy antigen-specific T cells. The large tissue mass of the liver has also been suggested to act as a cytokine sink, with the potential to exhaust the immune response. In this review, we outline the growing body of evidence, from experimental models and clinical transplantation, which supports a role for large tissue mass and high antigen dose in the induction of tolerance. We also discuss a novel gene therapy approach to exploit this dose effect and induce antigen-specific tolerance robust enough to overcome a primed T cell memory response.

scholarly journals DICER1 and PRKRA in Colon Adenocarcinoma

2008 ◽  
Vol 3 ◽  
pp. BMI.S600 ◽  
Author(s):  
S. Chiosea ◽  
M. Acquafondata ◽  
J. Luo ◽  
SF. Kuan ◽  
RR. Seethala
Keyword(s):  
Rna Interference ◽  
Gene Array ◽  
Colon Adenocarcinoma ◽  
Clinicopathologic Features ◽  
Array Analysis ◽  
Gene Array Analysis ◽  
Microrna Profile ◽  
The Status ◽  
And Function ◽  
Dicer1 Expression

Differential microRNA expression in colon adenocarcinoma (CA) was previously reported. MicroRNA biogenesis and function requires a set of proteins designated as the microRNA machinery, which includes DICER1 and PRKRA. Loss of heterozygosity at 14q32.13 DICER1 locus was detected in up to 60% of CA cases. The in silico gene array analysis of CA showed down-regulation of DICER1 and an up-regulation of PRKRA. Immunohistochemically, DICER1 expression was abnormal in 65% of CA (95 of 147 cases). PRKRA was deregulated in 70% of CA (32 of 46 cases). Expression of DICER1 and PRKRA was correlated with clinicopathologic features of CA. DICER1 up-regulation was seen more commonly in women. Only 10 of 46 cases immunostained for both DICER1 and PRKRA showed normal levels of both DICER1 and PRKRA. Microsatellite status of 32 cases was determined. Microsatellite instable cases showed DICER1 up-regulation more commonly when compared to microsatellite stable cases; however, this trend was not statistically significant. Abnormal DICER1 and/or PRKRA expression might explain the observed changes in microRNA profile. The status of the endogenous DICER1 and PRKRA in CA may help to predict the response to future RNA interference-based therapy.

Stability of gene expression in postmortem brain revealed by cDNA gene array analysis

2002 ◽  
Vol 942 (1-2) ◽  
pp. 120-123 ◽  
Author(s):  
Stacey A. Trotter ◽  
Louis B. Brill II ◽  
James P. Bennett
Keyword(s):  
Gene Expression ◽  
Gene Array ◽  
Postmortem Brain ◽  
Array Analysis ◽  
Gene Array Analysis

Gene array analysis of the expression profile associated with intestinal cell differentiation

2001 ◽  
Vol 120 (5) ◽  
pp. A88
Author(s):  
Qingding Wang ◽  
Robert Thomas ◽  
Nan Li ◽  
Xiaofu Wang ◽  
B. Mark Evers
Keyword(s):  
Cell Differentiation ◽  
Expression Profile ◽  
Gene Array ◽  
Intestinal Cell ◽  
Array Analysis ◽  
Gene Array Analysis

scholarly journals Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival

Oncogene ◽  
2008 ◽  
Vol 27 (44) ◽  
pp. 5856-5866 ◽  
Author(s):  
S Wotton ◽  
A Terry ◽  
A Kilbey ◽  
A Jenkins ◽  
P Herzyk ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Gene Array ◽  
Array Analysis ◽  
Gene Array Analysis
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