scholarly journals Hepatopulmonary syndrome and portopulmonary hypertension in the model for end-stage liver disease (MELD) era

2004 ◽  
Vol 10 (S10) ◽  
pp. S54-S58 ◽  
Author(s):  
M. Susan Mandell
Keyword(s):  
Liver Disease ◽  
Hepatopulmonary Syndrome ◽  
Portopulmonary Hypertension ◽  
End Stage Liver Disease ◽  
End Stage

Hepatopulmonary syndrome as the first and only manifestation of cirrhosis in a patient with hypopituitarism

2021 ◽  
Vol 14 (9) ◽  
pp. e244805
Author(s):  
Eman Alabsawy ◽  
Yassen Serry ◽  
Sreelakshmi Kotha ◽  
Philip Berry ◽  
Giovanni Tritto
Keyword(s):  
Liver Disease ◽  
Fatty Liver Disease ◽  
Hepatopulmonary Syndrome ◽  
Progressive Dyspnoea ◽  
Alcoholic Fatty Liver ◽  
End Stage Liver Disease ◽  
Pituitary Dysfunction ◽  
Vascular Dilatation ◽  
End Stage ◽  
Alcoholic Fatty Liver Disease

Hepatopulmonary syndrome (HPS) is characterised by the development of intrapulmonary arteriovenous blood shunts and vascular dilatation with consequent hypoxaemia, usually in the context of end-stage liver disease (ESLD). The estimated incidence of HPS in ESLD has been reported to be 13%–47%. Chronic liver disease has been described in patients with hypothalamic–pituitary dysfunction, mainly in the form of non-alcoholic fatty liver disease due to metabolic syndrome, with occasional progression to cirrhosis. We report a challenging case of a 27-year-old man with a background of hypopituitarism with no known liver disease who presented with progressive dyspnoea and hypoxaemia and was eventually diagnosed with severe HPS.

Model for end-stage liver disease (MELD) exception for portopulmonary hypertension

2006 ◽  
Vol 12 (S3) ◽  
pp. S114-S116 ◽  
Author(s):  
Michael J. Krowka ◽  
Michael B. Fallon ◽  
David C. Mulligan ◽  
Robert G. Gish
Keyword(s):  
Liver Disease ◽  
Portopulmonary Hypertension ◽  
End Stage Liver Disease ◽  
End Stage

Acute Respiratory Failure and Pulmonary Complications in End-Stage Liver Disease

2018 ◽  
Vol 39 (05) ◽  
pp. 546-555 ◽  
Author(s):  
Tisha Wang ◽  
Igor Barjaktarevic ◽  
Steven Chang ◽  
Nida Qadir
Keyword(s):  
Liver Disease ◽  
Respiratory Failure ◽  
Acute Respiratory Failure ◽  
High Risk Patient ◽  
Volume Overload ◽  
Hepatopulmonary Syndrome ◽  
Pulmonary Complications ◽  
Current Evidence ◽  
End Stage Liver Disease ◽  
End Stage

AbstractAcute respiratory failure has a high mortality in patients with end-stage liver disease (ESLD). These patients may develop acute respiratory failure for reasons specific to advanced liver disease, including hepatopulmonary syndrome, portopulmonary hypertension, and hepatic hydrothorax. They may also develop respiratory complications due to conditions seen in the general intensive care unit population to which ESLD patients are at higher risk, including infection, volume overload, and the acute respiratory distress syndrome. Management of these patients is complicated and multifaceted, and a comprehensive understanding of the etiologies and treatment of acute respiratory failure is critical in this high-risk patient population. This article reviews current evidence surrounding the prevalence, management, and complications of the various etiologies of acute respiratory failure in ESLD patients.

Cardiac involvement in patients with end-stage liver disease, beyond the hepatopulmonary syndrome

2019 ◽  
Vol 219 (1) ◽  
pp. 59-60
Author(s):  
S. Colunga Blanco ◽  
C. Corros Vicente ◽  
A. García Campos ◽  
J.M. de la Hera Galarza
Keyword(s):  
Liver Disease ◽  
Cardiac Involvement ◽  
Hepatopulmonary Syndrome ◽  
End Stage Liver Disease ◽  
End Stage

scholarly journals Role of echocardiography in screening for portopulmonary hypertension in liver transplant candidates: a meta-analysis

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9243
Author(s):  
Xin Yin ◽  
Yueming Shao ◽  
Yu Zhang ◽  
Hui Gao ◽  
Tingting Qin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Transplant ◽  
Likelihood Ratio ◽  
Meta Analysis ◽  
Positive Likelihood Ratio ◽  
Cochrane Library ◽  
Portopulmonary Hypertension ◽  
End Stage Liver Disease ◽  
Transplant Candidates ◽  
End Stage

Objectives To demonstrate the screening value of echocardiography for portopulmonary hypertension (POPH) in liver transplant candidates. Design Systematic review and meta-analysis. Background POPH is a complication of end-stage liver disease that adversely affects the outcome of orthotopic liver transplant. There are no specific symptoms in the early stage of POPH. POPH reduce the survival rate of patients with end-stage liver disease specially if they are not diagnosed. Therefore, early detection may improve prognosis. The objective of this study is to explore the screening value of echocardiography on liver transplant candidates for screening of POPH compared to right heart catheterization (RHC). Method PubMed, EMBASE and the Cochrane Library were searched by two independent reviewers for potentially eligible studies published up to 30 June 2019 to retrieve data based on per-patient analysis. STATA, Meta-DiSc, and RevMan were applied to perform this meta-analysis. Results Our search yielded 1576 studies, of which 11 satisfied the inclusion criteria. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the summary receiver operating characteristic (SROC) curve (AUC) of echocardiography for POPH were 0.85 (95% CI [0.65–0.94]), 0.83 (95% CI [0.73–0.90]), 4.99 (95% CI [3.03–8.21]), 0.19 (95% CI [0.07–0.46]), and 0.91 (95% CI [0.88–0.93]), respectively. Deeks’ funnel plot did not indicate the existence of publication bias (P = 0.66). Conclusions Echocardiography, a noninvasive modality, provides superior screening for POPH, but the diagnosis of POPH still requires RHC. PROSPERO registration number CRD42019144589.

scholarly journals Severe Hepatopulmonary Syndrome in a Child with Caroli Syndrome

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
W. De Jesus-Rojas ◽  
K. McBeth ◽  
A. Yadav ◽  
J. M. Stark ◽  
R. A. Mosquera ◽  
...  
Keyword(s):  
Liver Disease ◽  
End Stage Renal Disease ◽  
Adult Population ◽  
Hepatopulmonary Syndrome ◽  
End Stage Liver Disease ◽  
Caroli Syndrome ◽  
Stage Renal Disease ◽  
End Stage ◽  
Hypertension In Children ◽  
Improve Patient

Hepatopulmonary Syndrome (HPS) is a potential complication of chronic liver disease and is more commonly seen in the adult population. Caroli Syndrome is a rare inherited disorder characterized by intrahepatic ductal dilation and liver fibrosis that leads to portal hypertension. In children with liver disease, HPS should be considered in the differential diagnosis of prolonged, otherwise unexplained, hypoxemia. The presence of HPS can improve patient priority on the liver transplantation wait list, despite their Pediatric End-Stage Liver Disease (PELD) score. We present a 6-year-old girl with Caroli Syndrome and End-Stage Renal Disease who presented with persistent hypoxemia. The goal of this report is to increase awareness of HPS in children.

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