scholarly journals Hepatocellular carcinoma in HCV-infected patients awaiting liver transplantation: Genes involved in tumor progression

2004 ◽  
Vol 10 (5) ◽  
pp. 607-620 ◽  
Author(s):  
Valeria R. Mas ◽  
Daniel G. Maluf ◽  
Richard Stravitz ◽  
Catherine I. Dumur ◽  
Bradly Clark ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Tumor Progression

scholarly journals The Role of Bridge Therapy Prior to Orthotopic Liver Transplantation

2014 ◽  
Vol 12 (8) ◽  
pp. 1183-1191 ◽  
Author(s):  
Meena A. Prasad ◽  
Laura M. Kulik
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Tumor Progression ◽  
Orthotopic Liver Transplantation ◽  
Consensus Statement ◽  
Waiting List ◽  
Locoregional Therapy ◽  
Unresectable Hepatocellular Carcinoma ◽  
Bridge Therapy

Orthotopic liver transplantation (OLT) offers the best chance for cure in the setting of unresectable hepatocellular carcinoma (HCC). A consensus statement recommends locoregional therapy (LRT) be considered in patients with HCC who are expected to wait more than 6 months for OLT to diminish dropout from the waiting list because of tumor progression. This article reviews LRT as a bridge to OLT in patients with HCC.

scholarly journals Tumor Progression Pattern in Patients with Hepatocellular Carcinoma Awaiting for Liver Transplantation

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S411
Author(s):  
W. Hołówko ◽  
M. Grąt ◽  
K. Korzeniowski ◽  
T. Wróblewski ◽  
K. Zieniewicz
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Tumor Progression

scholarly journals PD-1 expression in hepatocellular carcinoma predicts liver-directed therapy response and bridge-to-transplant survival

2021 ◽  
Author(s):  
Kelley G. Núñez ◽  
Tyler Sandow ◽  
Daniel Fort ◽  
Mina Hibino ◽  
Paige Wright ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Tumor Progression ◽  
Lymphocyte Count ◽  
Univariate Analysis ◽  
Transplant Survival ◽  
Bridge To Transplant ◽  
Incomplete Response ◽  
Advanced Tumor ◽  
Increased Risk

Abstract Background Hepatocellular carcinoma (HCC) patients undergo liver-directed therapy (LDT) to control tumor burden while awaiting liver transplantation with response impacting waitlist survival. In this study, we investigate the link between absolute lymphocyte count (ALC) and PD-1 expression with response to LDT and bridge-to-transplant survival. Methods Treatment-naïve HCC patients (n = 86) undergoing LDT were enrolled at a single center from August 2016–March 2020. Response to LDT was determined using mRECIST. Blood samples were collected on the day of LDT and at follow-up. Cells were analyzed for phenotype by flow cytometry. Outcomes were liver transplantation or tumor progression. Results Incomplete response to initial LDT was associated with tumor progression precluding liver transplantation (OR: 7.6, 1.7 – 33.3, P < 0.001). Univariate analysis of baseline T cell phenotypes revealed ALC (OR: 0.44, 0.24–0.85, P = 0.009) as well as intermediate expression of PD-1 on CD4 (OR: 3.3, 1.03–10.3, P = 0.034) and CD8 T cells (OR: 3.0, 0.99–8.8 P = 0.043) associated with incomplete response to LDT. Elevations in PD-1 expression were associated with increased risk of bridge-to-transplant tumor progression (HR: 3.2, 1.2–9.4). In patients successfully bridged to liver transplantation, pre-treatment peripheral PD-1 profile was associated with advanced tumor staging (P < 0.005) with 2/4 of patients with elevations in PD-1 having T3-T4 TNM staging compared to 0 with low PD-1 expression. Conclusion Low lymphocyte count or elevated expression of the PD-1 checkpoint inhibitor is associated with incomplete response to LDT and increased risk of bridge-to-transplant tumor progression. Patients with impaired T cell homeostasis may benefit from PD-1 immunotherapy to improve response to LDT and improve bridge-to-transplant outcomes.

Outcome of patients with recurrent hepatocellular carcinoma after liver transplantation

2010 ◽  
Vol 48 (05) ◽  
Author(s):  
A Finkenstedt ◽  
I Graziadei ◽  
H Zoller ◽  
K Nachbaur ◽  
W Mark ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Recurrent Hepatocellular Carcinoma

Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
G Wiltberger ◽  
U Lange ◽  
H Hau ◽  
D Seehofer ◽  
F Krenzien ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Coffee Consumption ◽  
Protective Effects
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