scholarly journals Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractioned whole‐breast irradiation (LABRA trial)

2021 ◽  
Author(s):  
Jolien Robijns ◽  
Joy Lodewijckx ◽  
Sofie Puts ◽  
Sofie Vanmechelen ◽  
Leen Van Bever ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Photobiomodulation Therapy ◽  
Acute Radiation ◽  
Radiation Dermatitis ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Breast Cancer Patients

scholarly journals Objective Evaluation of Risk Factors for Radiation Dermatitis in Whole-Breast Irradiation Using the Spectrophotometric L*a*b Color-Space

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2444
Author(s):  
Alexander M. C. Böhner ◽  
David Koch ◽  
Frederic Carsten Schmeel ◽  
Fred Röhner ◽  
Felix Schoroth ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Background Radiation ◽  
Color Space ◽  
Radiation Dermatitis ◽  
Treatment Technique ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Breast Cancer Patients

Background: Radiation-induced dermatitis (RID) is frequent in breast cancer patients undergoing radiotherapy (RT). Spectrophotometry (SP) is an objective and reliable tool for assessing RID severity. Despite intensive research efforts during the past decades, no sustainable prophylactic and treatment strategies have been found. Estimation of new and reevaluation of established risk factors leading to severe RID is therefore of major importance. Methods: 142 early breast cancer patients underwent whole-breast irradiation following breast-conserving surgery. RID was evaluated by physician-assessed Common Terminology Criteria of Adverse Events (CTCAE v4.03). Spectrophotometers provided additional semi quantification of RID using the L*a*b color-space. A total of 24 patient- and treatment-related parameters as well as subjective patient-assessed symptoms were analyzed. Results: Values for a*max strongly correlated with the assessment of RID severity by physicians. Breast volume, initial darker skin, boost administration, and treatment technique were identified as risk factors for severe RID. RID severity positively correlated with the patients’ perception of pain, burning, and reduction of everyday activities. Conclusions: Physician-assessed RID gradings correlate with objective SP skin measurements. Treatment technique and high breast volumes were identified as objective and significant predictors of RID. Our data provide a solid benchmark for future studies on RID with objective SP.

OC-0334 Partial vs whole-breast irradiation for breast cancer patients in the randomized DBCG PBI trial

2021 ◽  
Vol 161 ◽  
pp. S247
Author(s):  
B. Offersen ◽  
J. Alsner ◽  
H.M. Nielsen ◽  
E.H. Jacobsen ◽  
M.H. Nielsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Breast Cancer Patients

Abstract P1-15-12: Development of a photonumeric scale for acute radiation dermatitis in breast cancer patients

2015 ◽  
Author(s):  
Dean Shumway ◽  
Eleanor M Walker ◽  
Nirav Kapadia ◽  
Thy Thy Do ◽  
Kent Griffith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Acute Radiation ◽  
Radiation Dermatitis ◽  
Breast Cancer Patients

scholarly journals Hydrofilm Polyurethane Films Reduce Radiation Dermatitis Severity in Hypofractionated Whole-Breast Irradiation: An Objective, Intra-Patient Randomized Dual-Center Assessment

Polymers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2112 ◽  
Author(s):  
Leonard Schmeel ◽  
David Koch ◽  
Frederic Schmeel ◽  
Bettina Bücheler ◽  
Christina Leitzen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Wound Care ◽  
Treatment Strategies ◽  
Preventive Treatment ◽  
Radiation Dermatitis ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Breast Cancer Patients ◽  
Radiation Induced ◽  
Hypofractionated Whole Breast Irradiation

Radiation-induced skin injury represents the most frequent side effect in breast cancer patients undergoing whole-breast irradiation (WBI). Numerous clinical studies on systemic and topical treatments for radiation dermatitis have failed to provide sustainable treatment strategies. While protective skin products such as dressings are undoubtedly the standard of care in wound care management, their utilization as preventive treatment in radiotherapy has been somewhat neglected in recent years. In this prospective, intra-patient randomized observational study, Hydrofilm polyurethane films were prophylactically applied to either the medial or lateral breast-half of 74 patients with breast cancer undergoing hypofractionated whole-breast irradiation following breast-preserving surgery. Maximum radiation dermatitis severity was assessed using Common Terminology Criteria for Adverse Events (CTCAE) v4.03 toxicity scores, photospectrometric erythema and pigmentation measurements and patient-assessed modified Radiation-Induced Skin Reaction Assessment Scale (RISRAS) scale. Phantom studies revealed a clinically negligible dose build-up of less than 0.1% with Hydrofilm. Compared to the control compartments physician-assessed radiation dermatitis severity was reduced in the hydrofilm compartments (mean 0.54 vs. 1.34; p = < 0.001). Objective photospectrometric skin measurements showed decreased erythema (p = 0.0001) and hyperpigmentation (p = 0.002) underneath Hydrofilm. Hydrofilm also completely prevented moist desquamation, and significantly reduced patients’ treatment-related symptoms of itching, burning, pain, and limitations of day-to-day-activities. Significant beneficial effects were observed in terms of radiation dermatitis severity, erythema, hyperpigmentation as well as subjective treatment-related symptom experiences, while adverse reactions were rare and minor. Therefore, a prophylactic application of Hydrofilm polyurethane films can be suggested in hypofractionated WBI.

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