Endocrine therapy with or without whole breast irradiation in low-risk breast cancer patients after breast-conserving surgery: 10-year results of the Austrian Breast and Colorectal Cancer Study Group 8A trial

2020 ◽  
Vol 127 ◽  
pp. 12-20 ◽  
Author(s):  
Gerd Fastner ◽  
Felix Sedlmayer ◽  
Joachim Widder ◽  
Martina Metz ◽  
Hans Geinitz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Cancer Patients ◽  
Breast Conserving Surgery ◽  
Study Group ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Breast Cancer Patients ◽  
Cancer Study Group ◽  
Risk Breast Cancer

scholarly journals A comparative study on hypofractionated whole-breast irradiation with sequential or simultaneous integrated boost on different positions after breast-conserving surgery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ting Yu ◽  
Yankang Li ◽  
Tao Sun ◽  
Min Xu ◽  
Wei Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Conserving Surgery ◽  
Simultaneous Integrated Boost ◽  
Whole Breast Irradiation ◽  
Breast Irradiation ◽  
Breast Cancer Patients ◽  
Sequential Boost ◽  
Integrated Boost ◽  
Hypofractionated Whole Breast Irradiation

AbstractThis study explored the dosimetric difference between hypofractionated whole-breast irradiation (HFWBI) with sequential boost (SEB) and simultaneous integrated boost (SIB) based on supine and prone positions to identify the superior boost mode and superior position. Thirty breast cancer patients eligible for HFWBI after breast-conserving surgery were enrolled. All patients underwent 3DCT simulation scanning in both supine and prone positions. For the SEB-HFWBI plan, the dose prescribed for the planning target volume (PTV) of whole breast (WB) was 2.67 Gy per fraction with a total of 15 fractions, followed by a sequential boost of 3.2 Gy per fraction to the PTV of tumor bed (TB) in 3 fractions. For the SIB-HFWBI plan, the dose prescribed for the PTV of WB was 2.67 Gy per fraction with a total of 15 fractions, with a simultaneously integrated boost of 3.2 Gy per fraction to the PTV of TB with a total of 15 fractions. Regardless of the position, for the PTV of TB, the conformal index (CI) in the SIB-HFWBI plans was greater than those in the SEB-HFWBI plans (T = − 8.114, − 8.114; both P < 0.05). The CI for the PTV of WB increased significantly in the prone position relative to the supine position in both two plans(Z = − 3.340, − 3.501; all P < 0.05). The study suggested that prone SIB-HFWBI might be more suitable for postoperative radiotherapy after breast-conserving surgery for early-stage breast cancer patients.

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