First experiences of photoacoustic imaging for detection of melanoma metastases in resected human lymph nodes

2012 ◽  
Vol 44 (7) ◽  
pp. 541-549 ◽  
Author(s):  
D.J. Grootendorst ◽  
J. Jose ◽  
M.W. Wouters ◽  
H. van Boven ◽  
J. Van der Hage ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Photoacoustic Imaging ◽  
Melanoma Metastases

Detection of Melanoma Metastases in Regional Lymph Nodes Using Multispectral Photoacoustic Imaging

2017 ◽  
Vol 225 (4) ◽  
pp. S189 ◽  
Author(s):  
Madalyn Neuwirth ◽  
Andrew J. Sinnamon ◽  
Susan Schultz ◽  
Chandra Seghal ◽  
George Xu ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Photoacoustic Imaging ◽  
Regional Lymph Nodes ◽  
Melanoma Metastases

scholarly journals Detection of Melanoma Metastases in Resected Human Lymph Nodes by Noninvasive Multispectral Photoacoustic Imaging

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Gerrit Cornelis Langhout ◽  
Diederik Johannes Grootendorst ◽  
Omgo Edo Nieweg ◽  
Michel Wilhelmus Jacobus Maria Wouters ◽  
Jos Alexander van der Hage ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Sentinel Node ◽  
Near Infrared ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Frozen Section ◽  
Photoacoustic Signal ◽  
Melanoma Metastasis ◽  
Prognostic Information ◽  
Melanoma Metastases

Objective. Sentinel node biopsy in patients with cutaneous melanoma improves staging, provides prognostic information, and leads to an increased survival in node-positive patients. However, frozen section analysis of the sentinel node is not reliable and definitive histopathology evaluation requires days, preventing intraoperative decision-making and immediate therapy. Photoacoustic imaging can evaluate intact lymph nodes, but specificity can be hampered by other absorbers such as hemoglobin. Near infrared multispectral photoacoustic imaging is a new approach that has the potential to selectively detect melanin. The purpose of the present study is to examine the potential of multispectral photoacoustic imaging to identify melanoma metastasis in human lymph nodes.Methods. Three metastatic and nine benign lymph nodes from eight melanoma patients were scannedex vivousing a Vevo LAZR©multispectral photoacoustic imager and were spectrally analyzed per pixel. The results were compared to histopathology as gold standard.Results. The nodal volume could be scanned within 20 minutes. An unmixing procedure was proposed to identify melanoma metastases with multispectral photoacoustic imaging. Ultrasound overlay enabled anatomical correlation. The penetration depth of the photoacoustic signal was up to 2 cm.Conclusion. Multispectral three-dimensional photoacoustic imaging allowed for selective identification of melanoma metastases in human lymph nodes.

scholarly journals Clinical Significance of Microscopic Melanoma Metastases in the Nonhottest Sentinel Lymph Nodes

JAMA Surgery ◽  
2015 ◽  
Vol 150 (5) ◽  
pp. 465 ◽  
Author(s):  
Su Luo ◽  
Alice Z. C. Lobo ◽  
Kenneth K. Tanabe ◽  
Alona Muzikansky ◽  
Tyler Durazzo ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Clinical Significance ◽  
Sentinel Lymph Nodes ◽  
Melanoma Metastases

Exploration of melanoma metastases in mice brains using endogenous contrast photoacoustic imaging

2017 ◽  
Vol 532 (2) ◽  
pp. 704-709 ◽  
Author(s):  
Jonathan Lavaud ◽  
Maxime Henry ◽  
Jean Luc Coll ◽  
Veronique Josserand
Keyword(s):  
Photoacoustic Imaging ◽  
Endogenous Contrast ◽  
Melanoma Metastases

scholarly journals Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast

2015 ◽  
Vol 20 (05) ◽  
pp. 1 ◽  
Author(s):  
James A. Guggenheim ◽  
Thomas J. Allen ◽  
Andrew Plumb ◽  
Edward Z. Zhang ◽  
Manuel Rodriguez-Justo ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Photoacoustic Imaging ◽  
Endogenous Lipid

scholarly journals Detection of microscopic melanoma metastases in sentinel lymph nodes

Cancer ◽  
1999 ◽  
Vol 86 (4) ◽  
pp. 617-627 ◽  
Author(s):  
Lawrence L. Yu ◽  
Thomas J. Flotte ◽  
Kenneth K. Tanabe ◽  
Michele A. Gadd ◽  
A. Benedict Cosimi ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Melanoma Metastases

scholarly journals Photoacoustic imaging probe for detecting lymph nodes and spreading of cancer at various depths

2017 ◽  
Vol 22 (9) ◽  
pp. 091513 ◽  
Author(s):  
Yong-Jae Lee ◽  
Eun-Ju Jeong ◽  
Hyun-Woo Song ◽  
Chang-Geun Ahn ◽  
Hyung Wook Noh ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Photoacoustic Imaging ◽  
Imaging Probe
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