In vivo quantification of fluorescent molecular markers in real-time by ratio imaging for diagnostic screening and image-guided surgery

2007 ◽  
Vol 39 (7) ◽  
pp. 605-613 ◽  
Author(s):  
A. Bogaards ◽  
H.J.C.M Sterenborg ◽  
J. Trachtenberg ◽  
B.C. Wilson ◽  
L. Lilge
Keyword(s):  
Molecular Markers ◽  
Real Time ◽  
Image Guided Surgery ◽  
Diagnostic Screening ◽  
Guided Surgery ◽  
Image Guided ◽  
Ratio Imaging

Real-time continuous image-guided surgery: Preclinical investigation in glossectomy

2017 ◽  
Vol 127 (10) ◽  
pp. E347-E353
Author(s):  
Reza Tabanfar ◽  
Jimmy Qiu ◽  
Harley Chan ◽  
Niousha Aflatouni ◽  
Robert Weersink ◽  
...  
Keyword(s):  
Real Time ◽  
Image Guided Surgery ◽  
Continuous Image ◽  
Guided Surgery ◽  
Image Guided ◽  
Preclinical Investigation

scholarly journals Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

2017 ◽  
Vol 8 (5) ◽  
pp. 3489-3493 ◽  
Author(s):  
Yao Sun ◽  
Mingmin Ding ◽  
Xiaodong Zeng ◽  
Yuling Xiao ◽  
Huaping Wu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Small Molecule ◽  
Tumor Imaging ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Bright Emission

This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores forin vivotumor imaging and NIR-II image-guided sentinel lymph node surgery.

V470 VIDEO: HYBRID REAL-TIME US SYSTEM FUSED WITH VIRTUAL 3D CT/MRI FOR IMAGE-GUIDED SURGERY

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Naoki Hirahara ◽  
Osamu Ukimura ◽  
Atsuko Fujihara ◽  
Tsuyoshi Iwata ◽  
Koji Okihara ◽  
...  
Keyword(s):  
Real Time ◽  
Image Guided Surgery ◽  
3D Ct ◽  
Guided Surgery ◽  
Image Guided

scholarly journals Optical Coherence Tomography for Retinal Surgery: Perioperative Analysis to Real-Time Four-Dimensional Image-Guided Surgery

2016 ◽  
Vol 57 (9) ◽  
pp. OCT37 ◽  
Author(s):  
Oscar M. Carrasco-Zevallos ◽  
Brenton Keller ◽  
Christian Viehland ◽  
Liangbo Shen ◽  
Michael I. Seider ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Real Time ◽  
Image Guided Surgery ◽  
Optical Coherence ◽  
Retinal Surgery ◽  
Dimensional Image ◽  
Guided Surgery ◽  
Image Guided

A novel in vivo Cerenkov luminescence image‐guided surgery on primary and metastatic colorectal cancer

2019 ◽  
Vol 13 (3) ◽  
Author(s):  
Zeyu Zhang ◽  
Yawei Qu ◽  
Yu Cao ◽  
Xiaojing Shi ◽  
Hongbo Guo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided

Image-guided surgery for tumor agnostic detection of solid tumors using the pH-activated micellar imaging agent ONM-100.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 3068-3068 ◽  
Author(s):  
Floris Jan Voskuil ◽  
Pieter Jan Steinkamp ◽  
Marjory Koller ◽  
Bert van der Vegt ◽  
Jan Johannes Doff ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Fluorescent Imaging ◽  
Activation Mechanism ◽  
Imaging Agent ◽  
Image Guided Surgery ◽  
Pharmacokinetic Data ◽  
Guided Surgery ◽  
Image Guided ◽  
Fluorescence Images

3068 Background: ONM-100, a micelle-based polymer imaging agent conjugated to indocyanine green (ICG) and with an exquisitely pH-sensitive binary activation mechanism, may be used for tumor detection. ONM-100 micelles dissociate in acidic environments resulting in activation of the fluorescent ICG tag. As nearly all solid cancer types are acidotic, ONM-100 has the potential to act as a broadly indicated tumor agnostic imaging agent. This first-in-human study investigates the safety and feasibility of ONM-100 as a tumor agnostic imaging agent for intra-operative fluorescent imaging of various solid tumors. Methods: ONM-100 was IV administered 24±8h prior to surgery in a dose escalation scheme (0.1-1.2mg/kg). Patients with histopathologically confirmed breast cancer (BC), head and neck squamous cell carcinoma (HNSCC), colorectal cancer (CRC) and esophageal cancer (EC) were included. Blood was drawn to assess safety and pharmacokinetic data. Intra-operative fluorescence images were collected before and after tumor excision. Post-excision fluorescence images were obtained from serially sliced specimens and correlated with standard histopathological assessment. Results: 30 patients (11 BC, 13 HNSCC, 3 EC, 3 CRC) were enrolled. No ONM-100 related serious adverse events were observed and the agent was well-tolerated. A strong and sharply demarcated fluorescent signal was observed in all patients with vital tumor tissue (median CNR ranging 1.85-14.05) which correlated with tumor on final histopathology. HNSCC and superficially located BC as well as peritoneal metastasis could be clearly visualized in vivo during surgery. In four patients (BC and HNSCC), perioperatively, tumors otherwise unnoticed by the surgeons were detected on the margin or wound bed using fluorescence imaging. Additionally, two BC tumor lesions were detected that were missed by conventional pre-operative imaging and pathological assessment. Conclusions: ONM-100 appears to be safe and enables fluorescent visualization of tumors both in vivo and ex vivo. The first-in-human data demonstrate the feasibility for potential use of ONM-100 for image guided surgery, margin assessment and detection of occult disease. Clinical trial information: NTR 7085.

scholarly journals Compact wearable dual-mode imaging system for real-time fluorescence image-guided surgery

2015 ◽  
Vol 20 (9) ◽  
pp. 096010 ◽  
Author(s):  
Nan Zhu ◽  
Chih-Yu Huang ◽  
Suman Mondal ◽  
Shengkui Gao ◽  
Chongyuan Huang ◽  
...  
Keyword(s):  
Real Time ◽  
Imaging System ◽  
Image Guided Surgery ◽  
Dual Mode ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Image Guided

scholarly journals Hands-free, wireless goggles for near-infrared fluorescence and real-time image-guided surgery

Surgery ◽  
2011 ◽  
Vol 149 (5) ◽  
pp. 689-698 ◽  
Author(s):  
Yang Liu ◽  
Adam Q. Bauer ◽  
Walter J. Akers ◽  
Gail Sudlow ◽  
Kexian Liang ◽  
...  
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Image Guided Surgery ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Image Guided ◽  
Real Time Image ◽  
Time Image
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