Laser-induced thermotherapy (LITT) elevates mRNA expression of connective tissue growth factor (CTGF) associated with reduced tumor growth of liver metastases compared to hepatic resection

2007 ◽  
Vol 39 (1) ◽  
pp. 42-50 ◽  
Author(s):  
Christoph Isbert ◽  
Jörg-Peter Ritz ◽  
André Roggan ◽  
Detlef Schuppan ◽  
Navid Ajubi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Tumor Growth ◽  
Liver Metastases ◽  
Hepatic Resection ◽  
Mrna Expression ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth

scholarly journals Kinetics of Connective Tissue Growth Factor Expression during Experimental Proliferative Glomerulonephritis

2001 ◽  
Vol 12 (3) ◽  
pp. 472-484
Author(s):  
YASUHIKO ITO ◽  
ROEL GOLDSCHMEDING ◽  
RICHARD J. BENDE ◽  
NIKE CLAESSEN ◽  
M. ANWAR CHAND ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Connective Tissue ◽  
Mrna Expression ◽  
Connective Tissue Growth Factor ◽  
Mesangial Cells ◽  
Tissue Growth ◽  
Proliferative Glomerulonephritis ◽  
Kinetics Of ◽  
Tgf Β1

Abstract. Connective tissue growth factor (CTGF) is a member of the CCN family of immediate early genes, which are involved in cell proliferation, migration, and matrix production. Recently, CTGF was observed to be strongly upregulated in human proliferative and fibrogenic renal disease. By in situ hybridization and reverse transcriptase-PCR, the expression of CTGF was investigated in experimental proliferative glomerulonephritis induced by injection of anti—Thy-1.1 antibody in the rat. CTGF expression in cultured rat mesangial cells and glomerular visceral epithelial cells (GVEC) was studied in response to transforming growth factor β (TGF-β), an essential pathogenetic factor in this model. In normal rat kidneys, only some GVEC expressed CTGF mRNA. In anti—Thy-1.1 nephritis, CTGF mRNA expression was strongly increased in extracapillary and mesangial proliferative lesions and in areas of periglomerular fibrosis. Early glomerular CTGF overexpression in GVEC coincided with a striking upregulation of TGF-β2 and to a lesser extent of TGF-β3. Glomerular CTGF mRNA expression was maximal at day 7, in association with increased TGF-β1 mRNA and protein expression. CTGF mRNA overexpression by parietal epithelial cells preceded the periglomerular appearance of α-smooth muscle actin—positive fibroblasts. In cultured mesangial cells, TGF-β1, -β2, and -β3 transiently increased the CTGF/glyceraldehyde phosphate dehydrogenase mRNA ratio up to threefold versus control at 4 h. In GVEC, upregulation of CTGF mRNA by these TGF-β isoforms was more sustained, being 8- to 16-fold versus control at 24 h. The kinetics of CTGF expression strongly suggest a role in glomerular repair, possibly downstream of TGF-β, in this model of transient renal injury.

Human Connective Tissue Growth Factor mRNA Expression of Epiretinal and Subretinal Fibrovascular Membranes: A Report of Three Cases

2002 ◽  
Vol 216 (4) ◽  
pp. 284-291 ◽  
Author(s):  
Peter Meyer ◽  
Kerstin Wunderlich ◽  
Hermann L. Kain ◽  
Christian Prünte ◽  
Josef Flammer
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Mrna Expression ◽  
Connective Tissue Growth Factor ◽  
Tissue Growth
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