Neuroprotective activity of new Δ3‐N ‐acylethanolamines in a focal ischemia stroke model

Lipids ◽  
2021 ◽  
Author(s):  
Rahau S. Shirazi ◽  
Mikhail Vyssotski ◽  
Kirill Lagutin ◽  
Dion Thompson ◽  
Christa MacDonald ◽  
...  
Keyword(s):  
Focal Ischemia ◽  
Neuroprotective Activity ◽  
Stroke Model

scholarly journals ADDITIVE NEUROPROTECTIVE EFFECT OF 3-HYDROXYPYRIDINE DERIVATIVES AND HUMAN ERYTHROPOETIN ANALOGUE ON A HEMORRHAGIC STROKE MODEL IN RATS

2020 ◽  
Vol 8 (3) ◽  
pp. 169-180
Author(s):  
P. D. Kolesnichenko ◽  
O. V. Scheblykina ◽  
N. I. Nesterova ◽  
D. V. Scheblykin ◽  
A. V. Nesterov ◽  
...  
Keyword(s):  
Survival Rate ◽  
Hemorrhagic Stroke ◽  
Neuroprotective Effect ◽  
Cerebrovascular Disorders ◽  
Neuroprotective Activity ◽  
Control Group ◽  
Stroke Model ◽  
Combined Use ◽  
Perifocal Edema ◽  
The Brain

The correction of free radical oxidation processes is one of the most promising strategies of neuroprotection in acute cerebrovascular disorders.The aim of the study is an experimental study of the neuroprotective effects of 3-hydroxypyridine and erythropoietin derivatives, as well as their combined use.Materials and methods. The study was performed on 109 male Wistar rats. The neuroprotective effect of the substances was studied on a hemorrhagic stroke model. The study drugs were administered to the animals intraperitoneally. Carbamylated darbepoetin was administered three times in advance at the dose of 100 µg/kg within intervals of 3 days, the last injection took place 1 hour before the operation (the total dose was 300 mg/kg). Etoxidol was administered once 1 hour before the surgery at the dose of 50 mg/kg. The survival rate, behavioral features and the state of the animals on the 1st, 3rd, 7th and 14th days were recorded, and the morphological assessment of the brain was carried out.Results. The investigated substances had a positive effect on both the survival rate of the animals during the first day and on the 14th day. The best survival rates on the 14th day were recorded in the group of a combined use of ethoxydol and carbamylated darbepoetin (75%). Thus, in this group of rats, a faster recovery of neurological disorders was already distinguished from the first day on. By the 7th day, more than 50% of the rats receiving the combination of the studied drugs, had had a slight neurological deficit (up to 3 points on the McGrow scale); by the 14th day there had been only minor changes in the neurological status in the rats of this group. A pronounced neuroprotective effect of the combination of 3-hydroxypyridine and erythropoietin derivatives has been confirmed by a histological examination of brain slices – a more rapid decrease in the size of perifocal edema and microcirculation disorders, less damage to neurons and glial elements, and faster processes of resorption and organization of hemorrhage. A macroscopic examination of the brain sections stained with triphenyltetrazolium chloride of the dying rats, showed that perifocal necrosis had been the main cause of high mortality in the control group after the 3rd day.Conclusion. As a result of the experiment, the nephroprotective effect of the studied derivatives of 3-hydroxypyridine and erythropoietin has been proved. Moreover, the combination of these drugs has shown a greater neuroprotective activity than their isolated use. The additive effect of these drugs was due to their action mechanism resulting from the synergism of various structures and components of the cells.

Neuroprotective activity of tamoxifen in permanent focal ischemia

2003 ◽  
Vol 99 (1) ◽  
pp. 138-142 ◽  
Author(s):  
Harold K. Kimelberg ◽  
Yiqiang Jin ◽  
Carol Charniga ◽  
Paul J. Feustel
Keyword(s):  
Rat Model ◽  
Infarct Volume ◽  
Focal Ischemia ◽  
Neuroprotective Activity ◽  
Therapeutic Window ◽  
Protective Effects ◽  
Content Type ◽  
Mca Occlusion ◽  
Fine Print ◽  
Permanent Focal Ischemia

Object. The authors have previously shown that tamoxifen is effective in protecting brain tissue from ischemic injury in a rat model of reversible focal ischemia. In this study the authors tested whether similar protective effects are found in a rat model of permanent focal ischemia (permanent middle cerebral artery [MCA] occlusion). Methods. Tamoxifen (20 mg/kg) was given either before or at 1, 3, or 6 hours after permanent MCA occlusion in rats, with sustaining doses given every 12 hours thereafter. The median infarct volume measured after 72 hours was 113 mm3 for the vehicle (dimethyl sulfoxide) groups, compared with 31 mm3 for pretreatment, and 14, 27, and 98 mm3 for treatment beginning at 1, 3, and 6 hours, respectively, after permanent MCA occlusion. The infarct reductions in the pretreated and 1- and 3-hour post—MCA occlusion treatment groups were statistically significant (p < 0.05). At 3 hours after permanent MCA occlusion, tamoxifen also significantly reduced the infarct size at a lower dose of 5 mg/kg but not at 1 mg/kg; the same sustaining doses of 5 and 1 mg/kg were given every 12 hours. Conclusions. Tamoxifen is as effective in a permanent model of focal ischemia as it is in the reversible model, and the therapeutic window of 3 hours after initiation of ischemia is identical. This effectiveness is likely due to several properties of the drug, including its known ability to cross the blood—brain barrier. Because tamoxifen has been administered safely in humans for treatment of gliomas at similarly high doses to those used in this study, it may be clinically useful as a treatment for ischemic stroke.

Khat affects apoptosis and related gene XIAP and Smac expression following transient focal ischemia in rats

2010 ◽  
Vol 34 (8) ◽  
pp. S16-S16
Author(s):  
Fang‑fang Bi ◽  
Hadi M. Mujlli ◽  
Yue‑qiang Hu ◽  
Fa‑fa Tian ◽  
Zhi‑guo Wu ◽  
...  
Keyword(s):  
Focal Ischemia ◽  
Related Gene ◽  
Transient Focal Ischemia

Flavonoid-glycosides from Rumex aquaticus with neuroprotective activity

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
O Orban-Gyapai ◽  
A Raghavan ◽  
A Vasas ◽  
P Forgo ◽  
ZA Shah ◽  
...  
Keyword(s):  
Neuroprotective Activity ◽  
Flavonoid Glycosides

Early proliferative response of radial glia-like progenitor cells in the dentate gyrus following focal ischemia

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
A Kunze ◽  
S Grass ◽  
O.W Witte ◽  
G Kempermann ◽  
C Redecker
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Proliferative Response ◽  
Radial Glia ◽  
Focal Ischemia
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