scholarly journals Gut microbial fatty acid metabolites (KetoA and KetoC) affect the progression of nonalcoholic steatohepatitis and reverse cholesterol transport metabolism in mouse model

Lipids ◽  
2020 ◽  
Vol 55 (2) ◽  
pp. 151-162 ◽  
Author(s):  
Neng Tanty Sofyana ◽  
Jiawen Zheng ◽  
Yuki Manabe ◽  
Yuta Yamamoto ◽  
Shigenobu Kishino ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Mouse Model ◽  
Nonalcoholic Steatohepatitis ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Acid Metabolites ◽  
Microbial Fatty Acid ◽  
Fatty Acid Metabolites

scholarly journals Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes

Lipids ◽  
2015 ◽  
Vol 50 (11) ◽  
pp. 1093-1102 ◽  
Author(s):  
Tharnath Nanthirudjanar ◽  
Hidehiro Furumoto ◽  
Jiawen Zheng ◽  
Young-Il Kim ◽  
Tsuyoshi Goto ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Acid Metabolites ◽  
Microbial Fatty Acid ◽  
Fatty Acid Metabolites

scholarly journals Fatty Acid Metabolites in Rapidly Proliferating Breast Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63076 ◽  
Author(s):  
Joseph T. O’Flaherty ◽  
Rhonda E. Wooten ◽  
Michael P. Samuel ◽  
Michael J. Thomas ◽  
Edward A. Levine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Acid Metabolites ◽  
Fatty Acid Metabolites

Macrophage-to-feces reverse cholesterol transport is impaired in a mouse model of diabetes

2014 ◽  
Vol 235 (2) ◽  
pp. e182-e183
Author(s):  
T.L. Errico ◽  
X. Chen ◽  
D. Santos ◽  
H. Quesada-Vázquez ◽  
J.M. Martín-Campos ◽  
...  
Keyword(s):  
Mouse Model ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport

Abstract 631: Lipid Composition of Gold Nanoparticle-Templated High-Density Lipoprotein Analogs Dictates Cholesterol Efflux Function

2014 ◽  
Vol 34 (suppl_1) ◽  
Author(s):  
R Kannan Mutharasan ◽  
Amritha T Singh ◽  
Kaylin M McMahon ◽  
C Shad Thaxton
Keyword(s):  
Fatty Acid ◽  
Lipid Content ◽  
Lipid Composition ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Efflux ◽  
Lipid Membrane ◽  
Density Lipoprotein ◽  
High Density ◽  
High Density Lipoproteins ◽  
Cholesterol Transport

Background: Reverse cholesterol transport, the process by which cholesterol is effluxed from cells to high-density lipoproteins (HDL) and is delivered to the liver for clearance, is a promising pathway to augment for treatment of atherosclerosis. Though structure-function relationships for nascent, discoidal HDL and cholesterol efflux have been well studied, how the lipid composition of spherical HDL species - which varies in pathophysiological conditions - impacts their ability to mediate cholesterol efflux has not been investigated. Methods and Results: Spherical gold nanoparticles (5 nm) were used to synthesize spherical HDL analogs (HDL-NP) by adding ApoAI protein, and various lipids. With this strategy a panel of HDL-NP varying in lipid content was generated. HDL-NP designs tested include: dipalmitylphosphatidylcholine (DPPC, saturated fatty acid), dioleoylphosphatidylcholine (DOPC, unsaturated fatty acid), sphingomyelin, lysophosphatidylcholine (LPC), and mixtures thereof. All of these species are found in natural HDL. After characterizing protein and lipid stoichiometry of the purified HDL-NP, these HDL-NP designs were tested in the cellular reverse cholesterol transport assay using J774 mouse macrophages. These studies demonstrate that all HDL-NP designs mediate more efflux than equimolar amounts of ApoAI protein control, and further demonstrate that HDL-NP designs incorporating unsaturated phospholipid (DOPC), sphingomyelin, and LPC - each of which can increase disorder in the lipid membrane and thus give rise to opportunity for cholesterol to intercalate and bind - enhance cholesterol efflux compared to saturated phospholipid (DPPC) design. Conclusion: In summary, these results demonstrate that lipid content of HDL-NP - analogs of spherical HDL - dictates cholesterol efflux function, a finding which sheds light on the functional importance of lipid content variation seen in mature, spherical HDL species.

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