scholarly journals Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

Hepatology ◽  
2010 ◽  
Vol 52 (2) ◽  
pp. 774-788 ◽  
Author(s):  
Brent A. Neuschwander-Tetri
Keyword(s):  
Fatty Acid ◽  
Nonalcoholic Steatohepatitis ◽  
Acid Metabolites ◽  
Hepatic Lipotoxicity ◽  
Fatty Acid Metabolites

The Role of Fatty Acid Metabolites in the Differentiation of the Human Monocyte-Like Cell Line U937

1988 ◽  
Vol 44 (1) ◽  
pp. 51-57 ◽  
Author(s):  
John S. Bomalaski ◽  
Bruce Freundlich ◽  
Sheldon Steiner ◽  
Mike A. Clark
Keyword(s):  
Fatty Acid ◽  
Cell Line ◽  
Human Monocyte ◽  
Acid Metabolites ◽  
Fatty Acid Metabolites

scholarly journals The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis

2021 ◽  
Vol 12 ◽  
Author(s):  
Silke Baldewijns ◽  
Mart Sillen ◽  
Ilse Palmans ◽  
Paul Vandecruys ◽  
Patrick Van Dijck ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Effective Means ◽  
Significant Proportion ◽  
Treatment Strategies ◽  
Short Chain Fatty Acids ◽  
Acid Metabolites ◽  
Vaginal Health ◽  
Novel Treatment Strategies ◽  
Fatty Acid Metabolites

Although the vast majority of women encounters at least one vaginal infection during their life, the amount of microbiome-related research performed in this area lags behind compared to alternative niches such as the intestinal tract. As a result, effective means of diagnosis and treatment, especially of recurrent infections, are limited. The role of the metabolome in vaginal health is largely elusive. It has been shown that lactate produced by the numerous lactobacilli present promotes health by limiting the chance of infection. Short chain fatty acids (SCFA) have been mainly linked to dysbiosis, although the causality of this relationship is still under debate. In this review, we aim to bring together information on the role of the vaginal metabolome and microbiome in infections caused by Candida. Vulvovaginal candidiasis affects near to 70% of all women at least once in their life with a significant proportion of women suffering from the recurrent variant. We assess the role of fatty acid metabolites, mainly SCFA and lactate, in onset of infection and virulence of the fungal pathogen. In addition, we pinpoint where lack of research limits our understanding of the molecular processes involved and restricts the possibility of developing novel treatment strategies.

scholarly journals Fatty Acid Metabolites in Rapidly Proliferating Breast Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63076 ◽  
Author(s):  
Joseph T. O’Flaherty ◽  
Rhonda E. Wooten ◽  
Michael P. Samuel ◽  
Michael J. Thomas ◽  
Edward A. Levine ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Acid Metabolites ◽  
Fatty Acid Metabolites

scholarly journals Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

2019 ◽  
Vol 30 (3) ◽  
pp. 447-461.e5 ◽  
Author(s):  
Dequina A. Nicholas ◽  
Elizabeth A. Proctor ◽  
Madhur Agrawal ◽  
Anna C. Belkina ◽  
Stephen C. Van Nostrand ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Human Type ◽  
Acid Metabolites ◽  
Fatty Acid Metabolites
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