scholarly journals Tumor detection with transoral use of flexible endoscopy for unknown primary head and neck cancer

2021 ◽  
Author(s):  
Koji Ebisumoto ◽  
Akihiro Sakai ◽  
Daisuke Maki ◽  
Kevin Robinson ◽  
Tomoaki Murakami ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Flexible Endoscopy ◽  
Tumor Detection ◽  
Unknown Primary

scholarly journals Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

2020 ◽  
Author(s):  
Lars Axelsson ◽  
Erik Holmberg ◽  
Jan Nyman ◽  
Anders Högmo ◽  
Helena Sjödin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Multicenter Study ◽  
Performance Status ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
N Stage

Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPV-positive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p= 0.036), and N stage (p= 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and (chemo) radiation and primary (chemo) radiation gave similar survival outcomes. A randomized treatment study that includes quality of life is needed to establish the optimal treatment.

scholarly journals Carcinoma of Unknown Primary and the 8th Edition TNM Classification for Head and Neck Cancer

2021 ◽  
Author(s):  
Robert Boeker ◽  
Carmen Stromberger ◽  
Max Heiland ◽  
Benedicta Beck‐Broichsitter ◽  
Veit M. Hofmann ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tnm Classification ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
8Th Edition

scholarly journals Long‐term results of elective mucosal irradiation for head and neck cancer of unknown primary in Chinese population: The EMICUP study

2020 ◽  
Vol 9 (5) ◽  
pp. 1712-1720
Author(s):  
Shengjin Dou ◽  
Rongrong Li ◽  
Lin Zhang ◽  
Zhuoying Wang ◽  
Li Xie ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Chinese Population ◽  
Cancer Of Unknown Primary ◽  
Long Term Results ◽  
Unknown Primary

PET/CT Evaluation of Head and Neck Cancer of Unknown Primary

2019 ◽  
Vol 40 (5) ◽  
pp. 414-423 ◽  
Author(s):  
Megan Albertson ◽  
Srinivasa Chandra ◽  
Zafar Sayed ◽  
Craig Johnson
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Pet Ct ◽  
Ct Evaluation

Intensity-Modulated Radiotherapy for Head and Neck Cancer of Unknown Primary: Toxicity and Preliminary Efficacy

2008 ◽  
Vol 70 (4) ◽  
pp. 1100-1107 ◽  
Author(s):  
Michelle L. Klem ◽  
James G. Mechalakos ◽  
Suzanne L. Wolden ◽  
Michael J. Zelefsky ◽  
Bhuvanesh Singh ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Intensity Modulated

scholarly journals Utility of Panendoscopy for the Detection of Unknown Primary Head and Neck Cancer in Patients with a Negative PET/CT Scan

2011 ◽  
Vol 90 (8) ◽  
pp. E16-E20 ◽  
Author(s):  
Kavita M. Pattani ◽  
Michael Goodier ◽  
David Lilien ◽  
Todd Kupferman ◽  
Gloria Caldito ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Ct Scan ◽  
Head And Neck ◽  
Neck Cancer ◽  
Unknown Primary ◽  
Pet Ct ◽  
Pet Ct Scan

Which role plays specialized palliative care in patients with relapsed and/or metastatic head and neck cancer? A retrospective analysis in Southern Switzerland.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17503-e17503
Author(s):  
Vittoria G. Espeli ◽  
Claudia Gamondi ◽  
Tanja Fusi-Schmidhauser
Keyword(s):  
Palliative Care ◽  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Unknown Primary ◽  
Early Palliative Care ◽  
Significant Difference ◽  
Specialized Palliative Care ◽  
The Impact

e17503 Background: early palliative care (PC) for patients with advanced cancer improves quality of life, promotes home deaths and can improve survival. Limited data are available regarding PC in advanced head and neck cancer (HNC) patients. To investigate the effect of introducing specialized PC in patients with relapsed and/or metastatic head and neck cancer. Methods: between October 2010 and December 2018, the medical charts of all patients treated in the Oncology Institute of Southern Switzerland with relapsed and/or metastatic HNC were reviewed. Site, status of disease (metastatic at diagnosis, locally or metastatic relapsed), type and lines of treatment, treatment response and referral to specialist palliative care (yes or no) were documented. Comparisons were made between patients referred and non-referred to PC. Results: sixty-two patients with relapsed/metastatic HNC were identified, 32 (51.6%) of which were referred to specialized PC. Patients were mainly men (47, 75.8%), with a median age of 66 years (range 43 – 86). Forty-two patients (67.7%) had a metastatic disease and the most common site of tumor was the oropharynx (35.5%), followed by oral cavity (32.3%), larynx (16.1%), hypopharynx (12.9%), and unknown primary (3.2%). Forty-eight patients (77.4%) were treated with systemic treatment (75% in the PC group and 80% in the non-PC group, p = 0.638). The median overall survival was 8.1 months for all patients, 8 months for the PC group and 8.7 months for the non-PC group, without significant difference (p = 0.440). Of the deceased patients, 70% of the PC group and 73.3% of the non-PC group received chemotherapy in the last three months of life. A greater percentage of patients in the PC group died at home, but without significant difference (39.2% vs. 19%, p = 0.134). Conclusions: only half of the patient had access to specialized PC. Whereas it did not seem to affect overall survival nor influence chemotherapy prescription, it seemed to favor home deaths. Further studies investigating the impact of early PC in recurrent and/or metastatic HNC are needed to improve access to PC and maximize benefits.

Evaluation and Management of the Unknown Primary Carcinoma of the Head and Neck

2008 ◽  
Vol 6 (10) ◽  
pp. 1068-1075 ◽  
Author(s):  
Chad E. Galer ◽  
Merrill S. Kies
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Clinical Presentation ◽  
Treatment Strategies ◽  
Clinical Problem ◽  
Unknown Primary ◽  
Multidisciplinary Teams ◽  
Primary Origin ◽  
Unknown Primary Carcinoma

Squamous cell carcinoma of unknown primary origin in the head and neck is encountered as a recurring clinical problem in head and neck cancer clinics, affecting 3% to 25% of patients. This article describes the clinical presentation, appropriate evaluation, and treatment strategies for this important subgroup. Treatment—best carried out with multidisciplinary teams of specialists experienced in the care of head and neck cancer patients—is curative for most of these patients.

Sign in / Sign up

Export Citation Format

Share Document