scholarly journals Carcinoma of Unknown Primary and the 8th Edition TNM Classification for Head and Neck Cancer

2021 ◽  
Author(s):  
Robert Boeker ◽  
Carmen Stromberger ◽  
Max Heiland ◽  
Benedicta Beck‐Broichsitter ◽  
Veit M. Hofmann ◽  
...  
Author(s):  
Lars Axelsson ◽  
Erik Holmberg ◽  
Jan Nyman ◽  
Anders Högmo ◽  
Helena Sjödin ◽  
...  

Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPV-positive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p= 0.036), and N stage (p= 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and (chemo) radiation and primary (chemo) radiation gave similar survival outcomes. A randomized treatment study that includes quality of life is needed to establish the optimal treatment.


2021 ◽  
Vol 26 (4) ◽  
pp. 623-635
Author(s):  
Yoshihide Ota ◽  
◽  
Tadahide Noguchi ◽  
Eiichiro Ariji ◽  
Chihiro Fushimi ◽  
...  

AbstractFor doctors and other medical staff treating oral cancer, it is necessary to standardize the basic concepts and rules for oral cancer to achieve progress in its treatment, research, and diagnosis. Oral cancer is an integral part of head and neck cancer and is treated in accordance with the general rules for head and neck cancer. However, detailed rules based on the specific characteristics of oral cancer are essential. The objective of this article was to contribute to the development of the diagnosis, treatment, and research of oral cancer, based on the correct and useful medical information of clinical, surgical, pathological, and imaging findings accumulated from individual patients at various institutions. Our general rules were revised as the UICC was revised for the 8th edition and were published as the Japanese second edition in 2019. In this paper, the English edition of the “Rules” section is primarily presented.


2018 ◽  
Vol 55 (1) ◽  
pp. 4 ◽  
Author(s):  
Krishnakumar Thankappan ◽  
Narayana Subramaniam ◽  
Adharsh Anand ◽  
Deepak Balasubramanian ◽  
Subramania Iyer

2020 ◽  
Vol 9 (5) ◽  
pp. 1712-1720
Author(s):  
Shengjin Dou ◽  
Rongrong Li ◽  
Lin Zhang ◽  
Zhuoying Wang ◽  
Li Xie ◽  
...  

2019 ◽  
Vol 40 (5) ◽  
pp. 414-423 ◽  
Author(s):  
Megan Albertson ◽  
Srinivasa Chandra ◽  
Zafar Sayed ◽  
Craig Johnson

2008 ◽  
Vol 70 (4) ◽  
pp. 1100-1107 ◽  
Author(s):  
Michelle L. Klem ◽  
James G. Mechalakos ◽  
Suzanne L. Wolden ◽  
Michael J. Zelefsky ◽  
Bhuvanesh Singh ◽  
...  

2011 ◽  
Vol 90 (8) ◽  
pp. E16-E20 ◽  
Author(s):  
Kavita M. Pattani ◽  
Michael Goodier ◽  
David Lilien ◽  
Todd Kupferman ◽  
Gloria Caldito ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document