scholarly journals Diagnostic pathway and stage migration of sinonasal malignancies in the era of the COVID ‐19 pandemic

Author(s):  
Christian M. Meerwein ◽  
Thomas M. Stadler ◽  
Panagiotis Balermpas ◽  
Michael B. Soyka ◽  
David Holzmann
2004 ◽  
Vol 171 (4S) ◽  
pp. 466-466
Author(s):  
Stephen A. Boorjian ◽  
Casey K. Ng ◽  
Ravi Munver ◽  
R. Ernest Sosa ◽  
E. Darracott Vaughan ◽  
...  

Author(s):  
Alpen Patel ◽  
Samir Patel ◽  
Amar Miglani ◽  
Naresh Patel ◽  
Richard Hayden ◽  
...  

2019 ◽  
Author(s):  
Gautam Mehta ◽  
Shaan Raza ◽  
Shirley Su ◽  
Michael Kupferman ◽  
Ehab Hanna ◽  
...  

2019 ◽  
Author(s):  
Jordan Sibeoni ◽  
Emilie Manolios ◽  
Laurence Verneuil ◽  
Philippe Chanson ◽  
Anne Revah-Levy

2014 ◽  
Vol 46 (1) ◽  
pp. 103-121
Author(s):  
Elizabeth Rodriguez Fielder

This essay looks at the role of labor activism through the cultural work of El Teatro Campesino, the theater company that emerged from the farmworkers’ strike led by Cesear Chavez in Delano, California, during the mid-1960s. Through makeshift performances along the picket line, the farmworkers and their creative visionary, Luis Valdez, innovated Chicano/a performance and created an activist aesthetic that has continued to influence Chicano/a performance and art. Their productions, which started as small improvisational actos, drew from a wealth of transnational influences as well as from a larger proletariat and activist theater tradition. However, El Teatro Campesino adapted these techniques to their local resources. The result created a unique forum that enabled promotional education about unions and workers’ rights to exist side-by-side with themes of self-reflection and criticism concerning the risks of identity politics. The essay explores the methods by which El Teatro Campesino questioned and critiqued ethnic identity and argues for a more complex approach to their earlier picket-line entertainment. It proceeds to consider the importance of cultural production for labor mobilization, and argues for a more integrated analysis of the relationship between activism and art.


Author(s):  
Michel Paul Johan Teuben ◽  
Carsten Mand ◽  
Laura Moosdorf ◽  
Kai Sprengel ◽  
Alba Shehu ◽  
...  

Abstract Background Simultaneous trauma admissions expose medical professionals to increased workload. The impact of simultaneous trauma admissions on hospital allocation, therapy, and outcome is currently unclear. We hypothesized that multiple admission-scenarios impact the diagnostic pathway and outcome. Methods The TraumaRegister DGU® was utilized. Patients admitted between 2002–2015 with an ISS ≥ 9, treated with ATLS®- algorithms were included. Group ´IND´ included individual admissions, two individuals that were admitted within 60 min of each other were selected for group ´MULT´. Patients admitted within 10 min were considered as simultaneous (´SIM´) admissions. We compared patient and trauma characteristics, treatment, and outcomes between both groups. Results 132,382 admissions were included, and 4,462/3.4% MULTiple admissions were found. The SIM-group contained 1,686/1.3% patients. The overall median injury severity score was 17 and a mean age of 48 years was found. MULT patients were more frequently admitted to level-one trauma centers (68%) than individual trauma admissions were (58%, p < 0.001). Mean time to CT-scanning (24 vs. 26/28 min) was longer in MULT / SIM patients compared to individual admissions. No differences in utilization of damage control principles were seen. Moreover, mortality rates did not differ between the groups (13.1% in regular admissions and 11.4%/10,6% in MULT/SIM patients). Conclusion This study demonstrates that simultaneous treatment of injured patients is rare. Individuals treated in parallel with other patients were more often admitted to level-one trauma centers compared with individual patients. Although diagnostics take longer, treatment principles and mortality are equal in individual admissions and simultaneously admitted patients. More studies are required to optimize health care under these conditions.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Dehua Lu ◽  
Yanpu Wang ◽  
Ting Zhang ◽  
Feng Wang ◽  
Kui Li ◽  
...  

Abstract Background Adoptive T cell transfer-based immunotherapy yields unsatisfactory results in the treatment of solid tumors, partially owing to limited tumor infiltration and the immunosuppressive microenvironment in solid tumors. Therefore, strategies for the noninvasive tracking of adoptive T cells are critical for monitoring tumor infiltration and for guiding the development of novel combination therapies. Methods We developed a radiolabeling method for cytotoxic T lymphocytes (CTLs) that comprises metabolically labeling the cell surface glycans with azidosugars and then covalently conjugating them with 64Cu-1,4,7-triazacyclononanetriacetic acid-dibenzo-cyclooctyne (64Cu-NOTA-DBCO) using bioorthogonal chemistry. 64Cu-labeled control-CTLs and ovalbumin-specific CTLs (OVA-CTLs) were tracked using positron emission tomography (PET) in B16-OVA tumor-bearing mice. We also investigated the effects of focal adhesion kinase (FAK) inhibition on the antitumor efficacy of OVA-CTLs using a poly(lactic-co-glycolic) acid (PLGA)-encapsulated nanodrug (PLGA-FAKi). Results CTLs can be stably radiolabeled with 64Cu with a minimal effect on cell viability. PET imaging of 64Cu-OVA-CTLs enables noninvasive mapping of their in vivo behavior. Moreover, 64Cu-OVA-CTLs PET imaging revealed that PLGA-FAKi induced a significant increase in OVA-CTL infiltration into tumors, suggesting the potential for a combined therapy comprising OVA-CTLs and PLGA-FAKi. Further combination therapy studies confirmed that the PLGA-FAKi nanodrug markedly improved the antitumor effects of adoptive OVA-CTLs transfer by multiple mechanisms. Conclusion These findings demonstrated that metabolic radiolabeling followed by PET imaging can be used to sensitively profile the early-stage migration and tumor-targeting efficiency of adoptive T cells in vivo. This strategy presents opportunities for predicting the efficacy of cell-based adoptive therapies and for guiding combination regimens. Graphic Abstract


2021 ◽  
Vol 73 ◽  
pp. 101969
Author(s):  
Sarah Price ◽  
Gary A. Abel ◽  
Willie Hamilton

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