scholarly journals Dupilumab in CRSwNP : Responder Analysis Using Clinically Meaningful Efficacy Outcome Thresholds

2021 ◽  
Author(s):  
Chien‐Chia Chuang ◽  
Isabelle Guillemin ◽  
Claus Bachert ◽  
Stella E. Lee ◽  
Peter W. Hellings ◽  
...  
Keyword(s):  
Responder Analysis ◽  
Efficacy Outcome

scholarly journals PSS5 Cost per Responder Analysis of Latanoprostene Bunod Compared to Prostaglandin Analogs for OPEN-Angle Glaucoma in Canada

2020 ◽  
Vol 23 ◽  
pp. S733
Author(s):  
C. Beauchemin ◽  
J.N. Charron ◽  
K. Mathurin ◽  
K. Jobin Gervais ◽  
M. Barbeau ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Open Angle ◽  
Responder Analysis ◽  
Cost Per Responder

P-102: Cognitive effects of memantine in moderate to severe Alzheimer's disease: A responder analysis

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S131-S131
Author(s):  
Michael Tocco ◽  
E. Malca Resnick ◽  
Stephen M. Graham ◽  
Vojislav Pejovic
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Effects ◽  
Responder Analysis

scholarly journals The Effects of an Online Theory-Based Bone Health Program for Older Adults

2015 ◽  
Vol 36 (9) ◽  
pp. 1117-1144 ◽  
Author(s):  
Eun-Shim Nahm ◽  
Barbara Resnick ◽  
Clayton Brown ◽  
Shijun Zhu ◽  
Jay Magaziner ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Health ◽  
Calcium Intake ◽  
Health Program ◽  
Outcome Expectations ◽  
Control Group ◽  
Discussion Boards ◽  
Learning Modules ◽  
Osteoporosis Knowledge ◽  
Efficacy Outcome

An estimated 10 million Americans age 50 and older have osteoporosis, and many experience associated fractures. Although several interventions have been shown to be effective in preventing osteoporosis, their impact on bone health among older adults was limited. The aim of this study was, therefore, to examine the effects of a theory-based online bone health program (Bone Power program) for a large number of older adults. The 8-week program included learning modules, discussion boards, and other resources. Participants ( N = 866; M age = 62.5 years) were recruited online and randomized into a Bone Power or control group. At the end of the intervention, the Bone Power group showed significantly greater improvement over the control group in osteoporosis knowledge, self-efficacy/outcome expectations for calcium intake and exercise, and calcium intake and exercise behaviors. This study’s findings suggest that online health programs can be effective in improving older adults’ knowledge, beliefs, and health behaviors.

scholarly journals Current Psoriasis Efficacy Outcome Measures in Clinical Trials

2018 ◽  
Vol 7 (4) ◽  
pp. 261-268 ◽  
Author(s):  
Todd Wechter ◽  
Michael Heath ◽  
David Aung-Din ◽  
Dev Sahni ◽  
Abigail Cline ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Outcome Measures ◽  
Efficacy Outcome

scholarly journals Efficacy and Safety of Oritavancin Relative to Vancomycin for Patients with Acute Bacterial Skin and Skin Structure Infections (ABSSSI) in the Outpatient Setting: Results From the SOLO Clinical Trials

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Thomas P. Lodise ◽  
Mark Redell ◽  
Shannon O. Armstrong ◽  
Katherine A. Sulham ◽  
G. Ralph Corey
Keyword(s):  
Clinical Trials ◽  
Composite Endpoint ◽  
Outpatient Setting ◽  
Efficacy And Safety ◽  
Phase 3 ◽  
Double Blind ◽  
Skin Structure ◽  
Efficacy Outcome ◽  
End Of Treatment ◽  
Secondary Endpoints

Abstract Background The objective of this analysis was to evaluate the efficacy and safety of oritavancin compared with vancomycin for patients with acute bacterial skin and skin structure infections (ABSSSIs) who received treatment in the outpatient setting in the Phase 3 SOLO clinical trials. Methods SOLO I and SOLO II were 2 identically designed comparative, multicenter, double-blind, randomized studies to evaluate the efficacy and safety of a single 1200-mg dose of intravenous (IV) oritavancin versus 7–10 days of twice-daily IV vancomycin for the treatment of ABSSSI. Protocols were amended to allow enrolled patients to complete their entire course of antimicrobial therapy in an outpatient setting. The primary efficacy outcome was a composite endpoint (cessation of spread or reduction in size of the baseline lesion, absence of fever, and no rescue antibiotic at early clinical evaluation [ECE]) (48 to 72 hours). Key secondary endpoints included investigator-assessed clinical cure 7 to 14 days after end of treatment (posttherapy evaluation [PTE]) and 20% or greater reduction in lesion area at ECE. Safety was assessed until day 60. Results Seven hundred ninety-two patients (oritavancin, 392; vancomycin, 400) received entire course of treatment in the outpatient setting. Efficacy response rates at ECE and PTE were similar (primary composite endpoint at ECE: 80.4% vs 77.5% for oritavancin and vancomycin, respectively) as was incidence of adverse events. Five patients (1.3%) who received oritavancin and 9 (2.3%) vancomycin patients were subsequently admitted to a hospital. Conclusions Oritavancin provides a single-dose alternative to multidose vancomycin for treatment of ABSSSI in the outpatient setting.

scholarly journals Enhancing Self Efficacy Of Prolanis Group On Self Assesment Of Diabetic Foot Early Detection Based On Health Belief Model Theory And Bandura’s Self Efficacy

2020 ◽  
Vol 9 (2) ◽  
pp. 950-953
Author(s):  
Didik Susetiyanto Atmojo ◽  
Heny Kristanto ◽  
Hengky Irawan
Keyword(s):  
Diabetic Foot ◽  
Self Efficacy ◽  
Health Belief ◽  
Outcome Expectations ◽  
Wilcoxon Test ◽  
P Value ◽  
Self Assessment ◽  
Efficacy Outcome ◽  
Post Test ◽  
Belief Model

Diabetes Mellitus (DM) complications are serious problems for patients and their families. . The purpose of this study was to improve Self Efficacy on the ability to detect the risk of diabetic foot injury.The research design used was pre-experimental research with a one group pre-post test design approach. Respondents of this study were the Clinic Prolanis Group dr. Chreslina Subagyo, Kediri City  Collecting data with clinical questionnaire sheet self-efficacy skills in order to determine the increase in self-efficacy. Based on the Wilcoxon test above, the p value = 0.000, which means that action given caused a changed or increased in a person's self-assessment This study revealed that the potential impact of self-efficacy, outcome expectations considered in the education program for patients. Therefore, the use of self-efficacy theory when designing patient education interventions could enhance diabetes self-care      

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