Lesser Known Uses of γ‐Aminobutyric Acid Analogue Medications in Otolaryngology

2021 ◽  
Author(s):  
Nathaniel Miller ◽  
Michael Noller ◽  
Alex Yang ◽  
Edward D. McCoul ◽  
Anthony M. Tolisano ◽  
...  
Keyword(s):  
Aminobutyric Acid ◽  
Acid Analogue

scholarly journals Intrathecal baclofen pump – a viable therapeutic option in pregnancy

2010 ◽  
Vol 3 (3) ◽  
pp. 119-120 ◽  
Author(s):  
Saira S Tandon ◽  
Iffath Hoskins ◽  
Salman Azhar
Keyword(s):  
Animal Studies ◽  
Therapeutic Option ◽  
Intrathecal Baclofen ◽  
Reproductive Age ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Women Of Reproductive Age ◽  
American Academy Of Pediatrics ◽  
Human Dose ◽  
Acid Analogue

Baclofen, a gamma-aminobutyric acid analogue, is used as a muscle relaxant and antispasmodic to relieve symptoms in patients with intractable spasticity arising from cerebral or spinal aetiology such as in traumatic brain injury or multiple sclerosis. As it is often used in women of reproductive age, it is imperative to know the safety and associated maternal and fetal risks. The Food and Drug Administration has assigned the drug to Pregnancy Category C because of the lack of controlled data in humans. Animal studies have revealed an increased incidence of omphalocele if used in doses several times the recommended human dose. Baclofen should only be given during pregnancy when the benefits outweigh the risks. Baclofen is considered compatible with breast feeding by the American Academy of Pediatrics.

Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation*

1964 ◽  
Vol 11 (01) ◽  
pp. 064-074 ◽  
Author(s):  
Robert H Wagner ◽  
William D McLester ◽  
Marion Smith ◽  
K. M Brinkhous
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Factor Viii ◽  
Plasma Protein ◽  
Acid Precipitation ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Specific Procedure ◽  
Beta Alanine ◽  
Antihemophilic Factor

Summary1. The use of several amino acids, glycine, alpha-aminobutyric acid, alanine, beta-alanine, and gamma-aminobutyric acid, as plasma protein precipitants is described.2. A specific procedure is detailed for the preparation of canine antihemophilic factor (AHF, Factor VIII) in which glycine, beta-alanine, and gammaaminobutyric acid serve as the protein precipitants.3. Preliminary results are reported for the precipitation of bovine and human AHF with amino acids.

Sign in / Sign up

Export Citation Format

Share Document