In Response to Letter to the Editor Regarding Over‐the‐Counter Tinnitus “Cures”: Marketers' Promises Do Not Ring True

2020 ◽  
Vol 131 (1) ◽  
Author(s):  
Robert K. Jackler
Author(s):  
G.A. Miranda ◽  
M.A. Arroyo ◽  
C.A. Lucio ◽  
M. Mongeotti ◽  
S.S. Poolsawat

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.


1978 ◽  
Vol 9 (3) ◽  
pp. 197-200
Author(s):  
Peter B. Smith
Keyword(s):  

1994 ◽  
Vol 3 (1) ◽  
pp. 89-89
Author(s):  
Lawrence I. Shotland
Keyword(s):  

1994 ◽  
Vol 3 (1) ◽  
pp. 87-87
Author(s):  
David Cieliczka
Keyword(s):  

1994 ◽  
Vol 3 (1) ◽  
pp. 92-93
Author(s):  
Larry Engelmann
Keyword(s):  

1994 ◽  
Vol 3 (1) ◽  
pp. 92-92
Author(s):  
Gregory Frazer
Keyword(s):  

1994 ◽  
Vol 3 (1) ◽  
pp. 92-92
Author(s):  
Edwin L. Harless
Keyword(s):  

1995 ◽  
Vol 4 (3) ◽  
pp. 89-89
Author(s):  
Bill Fitzgibbon
Keyword(s):  

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