The Prognostic Role of Programmed Death‐Ligand 1 in Nasopharyngeal Carcinoma

2020 ◽  
Vol 130 (11) ◽  
pp. 2598-2606 ◽  
Author(s):  
Michael Wotman ◽  
Saori W. Herman ◽  
Peter Costantino ◽  
Tristan Tham
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prognostic Role ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals Prognostic role of programmed death-ligand 1 expression in patients with biliary tract cancer: a meta-analysis

Aging ◽  
2019 ◽  
Vol 11 (24) ◽  
pp. 12568-12580
Author(s):  
Changjiang Lei ◽  
Xiulan Peng ◽  
Xiaojun Gong ◽  
Ying Fan ◽  
Shenglin Wu ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Programmed Death Ligand 1 ◽  
Tract Cancer ◽  
Programmed Death

scholarly journals Prognostic Role of Programmed Death Ligand-1 on Tumor-Infiltrating Immune Cells in “High-Risk” Patients Following Radical Cystectomy: A Retrospective Cohort Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Chung Un Lee ◽  
Dong Hyeon Lee ◽  
Wan Song
Keyword(s):  
High Risk ◽  
Radical Cystectomy ◽  
Immune Cells ◽  
Tumor Recurrence ◽  
Prognostic Role ◽  
Programmed Death Ligand 1 ◽  
High Risk Patients ◽  
Programmed Death ◽  
Risk Patients

PurposeThe aim of this study is to investigate the prognostic role of programmed death ligand-1 (PD-L1) on tumor-infiltrating immune cells (TIICs) in patients after radical cystectomy (RC) for bladder cancer (BCa).Materials and MethodsWe retrospectively reviewed 92 “high-risk” (≥pT3a and/or pN+) patients who underwent RC for BCa, without adjuvant chemotherapy (AC), between April 2014 and December 2019. PD-L1 on TIICs was measured only using the VENTANA (SP-142) immunohistochemistry assay. Patients were categorized into three groups based to the percentage of the tumor area covered by PD-L1 on TIICs: IC0 (<1%), IC1 (≥1% and <5%), and IC2/3 (≥5%). Positive PD-L1 was defined as IC2/3 (≥5%). Kaplan–Meier survival analysis was used to illustrate recurrence-free survival (RFS), and Cox proportional hazard models were used to identify predictive factors of tumor recurrence.ResultsWithin the cohort, the proportions of PD-L1 IC0, IC1, and IC2/3 were 21.7%, 23.9%, and 54.4%, respectively. At follow-up (mean 31.3 months), tumor recurrence was identified in 49 patients (53.3%). Using multivariable analysis, tumor stage (pT4; P=0.005), positive lymph nodes (P=0.021), and positive PD-L1 on TIICs (P=0.010) were independent predictors of tumor recurrence. The 2- and 3-year RFS rates were 67.7% and 64.2% in negative PD-L1 on TIICs, while 27.8% and 22.3% in positive PD-L1 on TIICs, respectively.ConclusionsPositive PD-L1 on TIICs was significantly associated with poorer RFS in “high-risk” patients after RC without AC. Our results support the use of adjuvant immunotherapy in “high-risk” patients with positive PD-L1 on TIICs after RC.

Prognostic Role of Programmed Death Ligand-1 Expression in Breast Cancer: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 11 (6) ◽  
pp. 753-761 ◽  
Author(s):  
Xue Li ◽  
Minghuan Li ◽  
Zhen Lian ◽  
Hui Zhu ◽  
Li Kong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals Prognostic role of programmed-death ligand 1 (PD-L1) expressing tumor infiltrating lymphocytes in testicular germ cell tumors

Oncotarget ◽  
2017 ◽  
Vol 8 (13) ◽  
pp. 21794-21805 ◽  
Author(s):  
Michal Chovanec ◽  
Zuzana Cierna ◽  
Viera Miskovska ◽  
Katarina Machalekova ◽  
Daniela Svetlovska ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Tumor Infiltrating Lymphocytes ◽  
Testicular Germ Cell Tumors ◽  
Prognostic Role ◽  
Testicular Germ Cell ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Infiltrating Lymphocytes

scholarly journals Prognostic Role of Soluble Programmed Death Ligand 1 in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Guixiang Liao ◽  
Zhihong Zhao ◽  
Yuting Qian ◽  
Xiean Ling ◽  
Shanyi Chen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Progression Free Survival ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role ◽  
Free Survival ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

ObjectiveThe objective of this study was to explore whether soluble programmed death ligand 1 (sPD-L1) is a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC).MethodsA comprehensive search of electronic databases was carried out. Original studies with inclusion of sPD-L1, progression-free survival, and overall survival in NSCLC were eligible. The primary endpoints were overall survival and progression-free survival. Hazard ratios (HRs) and 95% confidence intervals (CIs) were applied for data analysis.ResultsEight studies involving 710 patients with NSCLC were included in the analysis. A pooled data analysis revealed that high levels of sPD-L1 were correlated with poorer overall survival (HR = 2.34; 95% CI = 1.82–3.00; P < 0.001) and progression-free survival (HR = 2.35; 95% CI = 1.62–3.40, P < 0.001). A subgroup analysis revealed that high levels of sPD-L1 were correlated with poor overall survival in patients treated with immunotherapy (HR = 2.40; 95% CI = 1.79–3.22; P < 0.001).ConclusionThis pooled analysis of published data suggests that sPD-L1 may serve as a readily available biomarker for survival in NSCLC patients treated with ICI based treatment. Prospective studies with well-designed standard assessment methods should be conducted to validate the prognostic role of sPD-L1 in NSCLC.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021283177.

scholarly journals The role of Programmed Death-Ligand 1 expression in nasopharyngeal carcinoma

2021 ◽  
Vol 50 (2) ◽  
pp. 174
Author(s):  
Nadya Dwi Karsa
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cancer Cells ◽  
Growth And Development ◽  
Cell Mediated Immunity ◽  
Significant Prognostic Factor ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Immunotherapy Target

ABSTRACTBackground: Nasopharyngeal carcinoma (NPC) is a malignant tumor that arises from the epithelial cell that cover surface of the nasopharynx, which has the highest incidence of all types of head and neck cancer. Cell-mediated immunity plays an important role in the growth and development of NPC. The expressions of Programmed Death-Ligand 1 (PD-L1) of NPC is still being debated and researched. Objective: To find out and understand the role of PD-L1 expression in NPC. Literature review: PD-L1 is a ligand from Programmed Death-1 (PD-1) receptors that could be expressed by cancer cells. When the PD-1/PD-L1 pathway is active, it promotes survival of cancer cells via anti apoptotic signals and inhibits the activation of signaling pathways, which are critical for survival of T cells. Conclusion: Various studies had found an increase of the PD-L1 expression in NPC cancer cells. PD-L1 is also a potentially important tumor immunotherapy target and can be a significant prognostic factor in NPC. ABSTRAKLatar belakang: Karsinoma nasofaring (KNF) merupakan suatu tumor ganas epitelial nasofaring yang mempunyai insiden tertinggi di antara kanker kepala dan leher. Imunitas selular mempunyai peran penting terhadap pertumbuhan dan perkembangan KNF. Ekspresi Programmed Death-Ligand  1 (PD-L1) pada KNF masih diperdebatkan dan diteliti. Tujuan: Mengetahui dan memahami peran PD-L1 terhadap kejadian KNF. Tinjauan Pustaka: PD-L1 merupakan ligan dari reseptor Programmed Death-1 (PD-1) yang dapat diekpresikan oleh sel kanker. Jalur PD-1 / PD-L1 yang teraktivasi akan melindungi sel kanker melalui sinyal anti apoptosis dan menghambat aktivasi jalur-jalur pengiriman sinyal lain yang sangat penting untuk kelangsungan hidup sel T. Kesimpulan: Berbagai penelitian menemukan adanya peningkatan ekspresi PD-L1 pada sel kanker KNF. PD-L1 menjadi suatu target imunoterapi yang sangat penting dalam meningkatkan respon imun terhadap sel kanker dan dapat dijadikan suatu faktor prognosis pada KNF.

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