HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes

2018 ◽  
Vol 129 (3) ◽  
pp. 684-691 ◽  
Author(s):  
Shayan Cheraghlou ◽  
Sina J. Torabi ◽  
Zain A. Husain ◽  
Michael D. Otremba ◽  
Heather A. Osborn ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Treatment Outcomes ◽  
Neck Cancer ◽  
Cancer Prognosis ◽  
Unknown Primary ◽  
Hpv Status

scholarly journals Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

2020 ◽  
Author(s):  
Lars Axelsson ◽  
Erik Holmberg ◽  
Jan Nyman ◽  
Anders Högmo ◽  
Helena Sjödin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Multicenter Study ◽  
Performance Status ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
N Stage

Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPV-positive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p= 0.036), and N stage (p= 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and (chemo) radiation and primary (chemo) radiation gave similar survival outcomes. A randomized treatment study that includes quality of life is needed to establish the optimal treatment.

scholarly journals Carcinoma of Unknown Primary and the 8th Edition TNM Classification for Head and Neck Cancer

2021 ◽  
Author(s):  
Robert Boeker ◽  
Carmen Stromberger ◽  
Max Heiland ◽  
Benedicta Beck‐Broichsitter ◽  
Veit M. Hofmann ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tnm Classification ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
8Th Edition

scholarly journals Long‐term results of elective mucosal irradiation for head and neck cancer of unknown primary in Chinese population: The EMICUP study

2020 ◽  
Vol 9 (5) ◽  
pp. 1712-1720
Author(s):  
Shengjin Dou ◽  
Rongrong Li ◽  
Lin Zhang ◽  
Zhuoying Wang ◽  
Li Xie ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Chinese Population ◽  
Cancer Of Unknown Primary ◽  
Long Term Results ◽  
Unknown Primary

PET/CT Evaluation of Head and Neck Cancer of Unknown Primary

2019 ◽  
Vol 40 (5) ◽  
pp. 414-423 ◽  
Author(s):  
Megan Albertson ◽  
Srinivasa Chandra ◽  
Zafar Sayed ◽  
Craig Johnson
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Pet Ct ◽  
Ct Evaluation

Intensity-Modulated Radiotherapy for Head and Neck Cancer of Unknown Primary: Toxicity and Preliminary Efficacy

2008 ◽  
Vol 70 (4) ◽  
pp. 1100-1107 ◽  
Author(s):  
Michelle L. Klem ◽  
James G. Mechalakos ◽  
Suzanne L. Wolden ◽  
Michael J. Zelefsky ◽  
Bhuvanesh Singh ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Intensity Modulated

PO-0662: Differential outcomes following radiotherapy by HPV status in N3 head and neck cancer

2014 ◽  
Vol 111 ◽  
pp. S5-S6
Author(s):  
E. Tran ◽  
S.H. Huang ◽  
J. Waldron ◽  
X. Shen ◽  
W. Xu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Differential Outcomes ◽  
Hpv Status

scholarly journals Privacy-preserving distributed learning of radiomics to predict overall survival and HPV status in head and neck cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Marta Bogowicz ◽  
Arthur Jochems ◽  
Timo M. Deist ◽  
Stephanie Tanadini-Lang ◽  
Shao Hui Huang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Distributed Learning ◽  
Privacy Preserving ◽  
Hpv Status
Sign in / Sign up

Export Citation Format

Share Document