Diagnostic significance of narrow-band imaging for detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral leukoplakia

2012 ◽  
Vol 122 (12) ◽  
pp. 2754-2761 ◽  
Author(s):  
Shih-Wei Yang ◽  
Yun-Shien Lee ◽  
Liang-Che Chang ◽  
Cheng-Cheng Hwang ◽  
Tai-An Chen
Keyword(s):  
Carcinoma In Situ ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Oral Leukoplakia ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Diagnostic Significance

scholarly journals Does high-grade dysplasia/carcinoma in situ of the biliary duct margin affect the prognosis of extrahepatic cholangiocarcinoma? A meta-analysis

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Qiao Ke ◽  
Bin Wang ◽  
Nanping Lin ◽  
Lei Wang ◽  
Jingfeng Liu
Keyword(s):  
Local Recurrence ◽  
Carcinoma In Situ ◽  
Meta Analysis ◽  
Surgical Margin ◽  
High Grade Dysplasia ◽  
Cochrane Library ◽  
Biliary Duct ◽  
High Grade ◽  
Extrahepatic Cholangiocarcinoma

Abstract Background High-grade dysplasia/carcinoma in situ (HGD/CIS) of the biliary duct margin was found to not affect the prognosis of patients with extrahepatic cholangiocarcinoma by recent studies, but it has not yet reached a conclusion. Methods Eligible studies were searched by PubMed, PMC, MedLine, Embase, the Cochrane Library, and Web of Science, from Jan. 1, 2000 to Jun. 30, 2019, investigating the influences of surgical margin status of biliary duct on the prognosis of patients with resectable extrahepatic cholangiocarcinoma. Overall survival (OS) and local recurrence were evaluated by odds ratio (OR) with 95% confidence interval (CI). Results A total of 11 studies were enrolled in this meta-analysis, including 1734 patients in the R0 group, 194 patients in the HGD/CIS group, and 229 patients in the invasive carcinoma (INV) group. The pooled OR for the 1-, 2-, and 3-year OS rate between HGD/CIS group and R0 group was 0.98 (95% CI 0.65~1.50), 1.01 (95% CI 0.73~1.41), and 0.98 (95% CI 0.72~1.34), respectively. The pooled OR for the 1-, 2-, and 3-year OS rate between HGD/CIS group and INV group was 1.83 (95% CI 1.09~3.06), 4.52 (95% CI 2.20~9.26), and 3.74 (95% CI 2.34~5.96), respectively. Subgroup analysis of extrahepatic cholangiocarcinoma at early stage showed that the pooled OR for the 1-, 2-, and 3-year OS rate between HGD/CIS group and R0 group was 0.54 (95% CI 0.21~1.36), 0.75 (95% CI 0.35~1.58), and 0.74 (95% CI 0.40~1.37), respectively, and the pooled OR for the 1-, 2-, and 3-year OS rate between HGD/CIS group and INV group was 3.47 (95% CI 1.09~11.02), 9.12 (95% CI 2.98~27.93), and 9.17 (95% CI 2.95~28.55), respectively. However, the pooled OR for the incidence of local recurrence between HGD/CIS group and R0 group was 3.54 (95% CI 1.66~7.53), and the pooled OR for the incidence of local recurrence between HGD/CIS group and INV group was 0.93 (95% CI 0.50~1.74). Conclusion With the current data, we concluded that HGD/CIS would increase the risk of local recurrence compared with R0, although it did not affect the prognosis of patients with extrahepatic cholangiocarcinoma regardless of TNM stage. However, the conclusion needs to be furtherly confirmed.

scholarly journals Anal condylomas: predictors of recurrence and progression to high-grade dysplasia/carcinoma in situ

2017 ◽  
Vol 8 (6) ◽  
pp. 1114-1115 ◽  
Author(s):  
Armando Peixoto ◽  
Marco Silva ◽  
Rui Castro ◽  
Rosa Coelho ◽  
Alexandre Sarmento ◽  
...  
Keyword(s):  
Carcinoma In Situ ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Predictors Of Recurrence

scholarly journals Mo1282 ADHERENCE TO RECOMMENDED SURVEILLANCE INTERVALS IS CHALLENGING FOR BARRETT'S ESOPHAGUS PATIENTS WITH HIGH-GRADE DYSPLASIA AND CARCINOMA IN-SITU

2020 ◽  
Vol 91 (6) ◽  
pp. AB415
Author(s):  
Phoebe S. Um ◽  
Megan Q. Chan ◽  
Alice Hinton ◽  
Sebastian Strobel ◽  
Kelly Haisley ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Carcinoma In Situ ◽  
High Grade Dysplasia ◽  
High Grade

Moderne endoskopische Bildgebungsverfahren für das Urothelkarzinom der Harnblase

2017 ◽  
Vol 48 (04) ◽  
pp. 296-305 ◽  
Author(s):  
M. Kriegmair ◽  
M. Ritter ◽  
M. Michel ◽  
C. Bolenz
Keyword(s):  
Carcinoma In Situ ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Optische Kohärenztomografie ◽  
Diagnostik Und Therapie ◽  
Molekulare Zielstrukturen ◽  
Eine Verbesserte

ZusammenfassungDie primäre Diagnostik und Therapie des Urothelkarzinoms (UCC) der Harnblase erfolgt endoskopisch. Eine möglichst sichere Differenzierung zwischen benignen Läsionen und maligne entartetem Urothel ist erforderlich. Die Weißlichtzystoskopie gilt als Goldstandard, jedoch bestehen Limitationen bei der Detektion kleiner Tumore und des Carcinoma in situ. Mit der Photodyamischen Diagnostik (PDD) und dem Narrow Band Imaging (NBI) stehen zwei klinisch etablierte Techniken zur Verfügung, die die Detektionsrate verbessern und die Rezidivrate eines Urothelkarzinoms senken können. Das Storz Professional Imaging Enhancement System (SPIES) beruht auf einer digitalen Kontrastverstärkung und wird aktuell in klinischen Studien evaluiert. Mit der konfokalen Laser-Endomikroskopie (CLE) wird das Prinzip der optischen Biopsie verfolgt. Sie erlaubt bereits intraoperativ die Darstellung des Gewebes mit einer der Lichtmikroskopie vergleichbaren Auflösung. Die optische Kohärenztomografie (OCT) stellt intraoperativ Querschnittsbilder der Harnblasenwand dar und liefert Informationen zur Eindringtiefe des Tumors. Eine weitere Ergänzung ist die Raman-Spektroskopie, die über Spektralanalysen die Beurteilung der Zusammensetzung von Material und Gewebe erlaubt. Die zunehmende molekulare Entschlüsselung des Urothelkarzinoms der Harnblase bietet neue Chancen für die Endoskopie. In Zukunft werden moderne Fotosensibilisatoren über molekulare Zielstrukturen spezifisch an Urothelkarzinomzellen binden, um malignes Gewebe sensitiver zu detektieren. Softwarebasierte Bildgebungsmodalitäten bieten neben der Unterstützung bei der Interpretation von endoskopischen Bildern diverse Möglichkeiten für eine verbesserte digitale Befunddokumentation und -kommunikation. Die vorliegende Arbeit stellt die modernen endoskopischen Bildgebungsverfahren vor und diskutiert deren potenziellen klinischen Nutzen.

Adenomas of the gallbladder. Morphologic features, expression of gastric and intestinal mucins, and incidence of high-grade dysplasia/carcinoma in situ and invasive carcinoma

2012 ◽  
Vol 43 (9) ◽  
pp. 1506-1513 ◽  
Author(s):  
Jorge Albores-Saavedra ◽  
Fredy Chablé-Montero ◽  
Marco Aurelio González-Romo ◽  
Manuel Ramírez Jaramillo ◽  
Donald E. Henson
Keyword(s):  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
High Grade Dysplasia ◽  
High Grade ◽  
Intestinal Mucins
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