scholarly journals Common genetic variants in the 8q24 region and risk of papillary thyroid cancer

2012 ◽  
Vol 122 (5) ◽  
pp. 1040-1042 ◽  
Author(s):  
Gila Neta ◽  
Chu-Ling Yu ◽  
Alina Brenner ◽  
Fangyi Gu ◽  
Amy Hutchinson ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Genetic Variants ◽  
Papillary Thyroid ◽  
Common Genetic Variants ◽  
8Q24 Region

scholarly journals Common genetic variants related to genomic integrity and risk of papillary thyroid cancer

2011 ◽  
Vol 32 (8) ◽  
pp. 1231-1237 ◽  
Author(s):  
Gila Neta ◽  
Alina V. Brenner ◽  
Erich M. Sturgis ◽  
Ruth M. Pfeiffer ◽  
Amy A. Hutchinson ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Genetic Variants ◽  
Papillary Thyroid ◽  
Genomic Integrity ◽  
Common Genetic Variants

scholarly journals Common Genetic Variants in Sex Hormone Pathway Genes and Papillary Thyroid Cancer Risk

Thyroid ◽  
2012 ◽  
Vol 22 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Sara J. Schonfeld ◽  
Gila Neta ◽  
Erich M. Sturgis ◽  
Ruth M. Pfeiffer ◽  
Amy A. Hutchinson ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Papillary Thyroid Cancer ◽  
Genetic Variants ◽  
Sex Hormone ◽  
Papillary Thyroid ◽  
Common Genetic Variants ◽  
Thyroid Cancer Risk

scholarly journals Common genetic variants in metabolism and detoxification pathways and the risk of papillary thyroid cancer.

2012 ◽  
Vol 19 (3) ◽  
pp. 333-344 ◽  
Author(s):  
Briseis Aschebrook-Kilfoy ◽  
Gila Neta ◽  
Alina V Brenner ◽  
Amy Hutchinson ◽  
Ruth M Pfeiffer ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Metal Binding ◽  
Gene Interaction ◽  
Nucleotide Polymorphisms ◽  
Papillary Thyroid ◽  
Single Nucleotide ◽  
Logistic Regression Models ◽  
False Discovery ◽  
Common Genetic Variants

Relationships are unclear between polymorphisms in genes involved in metabolism and detoxification of various chemicals and papillary thyroid cancer (PTC) risk as well as their potential modification by alcohol or tobacco intake. We evaluated associations between 1647 tagging single nucleotide polymorphisms (SNPs) in 132 candidate genes/regions involved in metabolism of exogenous and endogenous compounds (Phase I/II, oxidative stress, and metal binding pathways) and PTC risk in 344 PTC cases and 452 controls. For 15 selected regions and their respective SNPs, we also assessed interaction with alcohol and tobacco use. Logistic regression models were used to evaluate the main effect of SNPs (Ptrend) and interaction with alcohol/tobacco intake. Gene- and pathway-level associations and interactions (Pgene interaction) were evaluated by combining Ptrend values using the adaptive rank-truncated product method. While we found associations between PTC risk and nine SNPs (Ptrend≤0.01) and seven genes/regions (Pregion<0.05), none remained significant after correction for the false discovery rate. We found a significant interaction between UGT2B7 and NAT1 genes and alcohol intake (Pgene interaction=0.01 and 0.02 respectively) and between the CYP26B1 gene and tobacco intake (Pgene interaction=0.02). Our results are suggestive of interaction between the genetic polymorphisms in several detoxification genes and alcohol or tobacco intake on risk of PTC. Larger studies with improved exposure assessment should address potential modification of PTC risk by alcohol and tobacco intake to confirm or refute our findings.

scholarly journals Common Obesity-Related Genetic Variants and Papillary Thyroid Cancer Risk

2012 ◽  
Vol 21 (12) ◽  
pp. 2268-2271 ◽  
Author(s):  
Cari M. Kitahara ◽  
Gila Neta ◽  
Ruth M. Pfeiffer ◽  
Deukwoo Kwon ◽  
Li Xu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Papillary Thyroid Cancer ◽  
Genetic Variants ◽  
Papillary Thyroid ◽  
Thyroid Cancer Risk

Abstract #1086: Patient Experience with Severe Low Energy Following Total Thyroidectomy for Papillary Thyroid Cancer

2017 ◽  
Vol 23 ◽  
pp. 258
Author(s):  
Elizabeth Wendt ◽  
Maria Bates ◽  
Reese Randle ◽  
Jason Orne ◽  
Cameron Macdonald ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Cancer ◽  
Patient Experience ◽  
Low Energy ◽  
Papillary Thyroid
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