Lower airways may also be affected in asymptomatic patients with recent onset of allergic rhinitis

2010 ◽  
Vol 120 (7) ◽  
pp. 1288-1291 ◽  
Author(s):  
Giorgio Ciprandi ◽  
Ignazio Cirillo ◽  
Catherine Klersy
Keyword(s):  
Allergic Rhinitis ◽  
Recent Onset ◽  
Asymptomatic Patients ◽  
Lower Airways

The interaction between upper and lower airways in allergic rhinitis

2001 ◽  
Vol 26 (4) ◽  
pp. 341-341
Author(s):  
W. Fokkens ◽  
G.J. Braunstahl
Keyword(s):  
Allergic Rhinitis ◽  
Lower Airways

Cytokine expression in the lower airways of nonasthmatic subjects with allergic rhinitis: Influence of natural allergen exposure

2000 ◽  
Vol 106 (5) ◽  
pp. 904-910 ◽  
Author(s):  
Jamila Chakir ◽  
Michel Laviolette ◽  
Hélène Turcotte ◽  
Michel Boutet ◽  
Louis-Philippe Boulet
Keyword(s):  
Allergic Rhinitis ◽  
Allergen Exposure ◽  
Cytokine Expression ◽  
Lower Airways

Site-specific sensitization in a murine model of allergic rhinitis: Role of the upper airway in lower airways disease

2002 ◽  
Vol 110 (6) ◽  
pp. 891-898 ◽  
Author(s):  
Christine McCusker ◽  
Martin Chicoine ◽  
Qutayba Hamid ◽  
Bruce Mazer
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Upper Airway ◽  
Site Specific ◽  
Lower Airways

Relationship between Responses to Bronchodilation Testing and to Nasal Decongestion Testing in Patients with Allergic Rhinitis Alone

2009 ◽  
Vol 7 (3) ◽  
pp. 153-160 ◽  
Author(s):  
G. Ciprandi ◽  
A. Pistorio ◽  
M.A. Tosca ◽  
I. Cirillo ◽  
G.L. Marseglia
Keyword(s):  
Allergic Rhinitis ◽  
Skin Prick Test ◽  
Nasal Obstruction ◽  
Clinical Examination ◽  
Positive Response ◽  
Bronchial Obstruction ◽  
Prick Test ◽  
Large Group ◽  
Lower Airways

A remarkable relationship exists between upper and lower airways. Bronchial obstruction is a paramount feature of asthma as well as nasal obstruction of allergic rhinitis (AR). This study aims to evaluate the response to both bronchodilation and decongestion testing and their relationships in a large group of patients with moderate-severe persistent AR alone. Two hundred eleven patients with moderate-severe persistent AR were prospectively and consecutively evaluated. Clinical examination, skin prick test, spirometry, bronchodilation test, rhinomanometry, and decongestion test were performed on all patients. Seventeen subjects (8%) did not respond to any of the tests, 55 subjects (26.1%) were responders only to the decongestion test, 31 (14.7%) only to the bronchodilation test, and 108 subjects (51.2%) responded to both these tests. Longer AR duration was significantly associated with positive response to both tests (p<0.01). In conclusion, this study provides the first evidence that patients with moderate-severe persistent AR may frequently show reversibility to both bronchodilation and decongestion tests.

Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways

2003 ◽  
Vol 33 (5) ◽  
pp. 579-587 ◽  
Author(s):  
G.-J. Braunstahl ◽  
W. J. Fokkens ◽  
S. E. Overbeek ◽  
A. KleinJan ◽  
H. C. Hoogsteden ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Lower Airways ◽  
Inflammatory Changes

Eotaxin, but not IL-8, is increased in upper and lower airways of allergic rhinitis subjects after nasal allergen challenge

2011 ◽  
Vol 32 (3) ◽  
pp. 230-238 ◽  
Author(s):  
Aleksandra Semik-Orzech ◽  
Adam Barczyk ◽  
Ryszard Wiaderkiewicz ◽  
Władysław Pierzchała
Keyword(s):  
Allergic Rhinitis ◽  
Allergen Challenge ◽  
Lower Airways ◽  
Nasal Allergen Challenge

Global airways – a novel Standard Tests for Asthma, allergic Rhinitis, and chronic Rhinosinusitis (STARR-15)

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
V. Backer ◽  
K. Aanaes ◽  
S. Hansen ◽  
J. Petersen ◽  
C. von Buchwald
Keyword(s):  
Allergic Rhinitis ◽  
Process Analysis ◽  
Airway Disease ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Standard Test ◽  
Asthma Control Questionnaire ◽  
Patient Reported ◽  
Lower Airways ◽  
Snot 22

Background: Global airway disease, with symptoms from both upper and lower airways, is a challenging problem for clinicians. Our goal is to design one single standard test for the awareness of global airway diseases to be used in clinical setting. Material and Methods: During 2019, rhinologists and pulmonologists generated a pool of items based on literature, patient-reported outcome measures and clinical experience. The items were administered to 206 patients with known asthma, CRS, allergic rhinitis, or a combination thereof. The patients also completed the Asthma Control Questionnaire (ACQ-5) and the Sino-Nasal Outcome Test (SNOT-22). Using a mix of clinical knowledge and data-driven methods a global airways questionnaire was developed. Results: Mean ACQ score was highest in patients with all three, whereas the highest SNOT-22 score was observed in patients with CRS and asthma. After the development process, analysis of responses from 206 patients to 44 items on a new global airway’s questionnaire led to identification of 15 items that form the STARR-15 questionnaire with three underlying domains (an allergic rhinitis sub-factor, a CRS sub-factor and an asthma sub-factor). Conclusion: STARR-15 represents the first global airways questionnaire, to be used when examining patients with upper and lower airways symptoms. Future analyses are warranted to evaluate the clinical and psychometric properties of STARR-15.

scholarly journals Bronchial hyperreactivity and spirometric impairment in patients with allergic rhinitis

2005 ◽  
Vol 63 (2) ◽  
Author(s):  
I. Cirillo ◽  
A. Vizzaccaro ◽  
M.A. Tosca ◽  
S. Negrini ◽  
A.C. Negrini ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pollen Season ◽  
Seasonal Difference ◽  
Bronchial Hyperreactivity ◽  
Methacholine Challenge ◽  
Careful Evaluation ◽  
Large Group ◽  
Lower Airways ◽  
Significant Seasonal Difference

Background: The Link between allergic rhinitis and asthma is well known. Bronchial hyperreactivity (BHR) may be present in rhinitics. The present study is aimed at evaluating a large group of subjects suffering from allergic rhinitis alone to investigate the presence of spirometric impairment and BHR both during and outside the pollen season. Methods: 360 rhinitics (subdivided in 3 groups: seasonal, SAR, perennial, PAR, and polysensitized, PolysR) were investigated by spirometry and methacholine challenge. Results: There was a significant seasonal difference concerning the number of rhinitics with impaired FEV1 (p&lt;0.01 for SAR, p&lt;0.02 for PAR, and p&lt;0.03 for PolysR) and FEF25-75 (p&lt;0.05 for SAR, p&lt;0.03 for PAR, and p&lt;0.05 for PolysR) as well as with BHR (p&lt;0.05 for SAR and p&lt;0.03 for PAR). Conclusions: This study evidences that an impairment of spirometric parameters and BHR may be observed in patients with allergic rhinitis alone. Thus, careful evaluation of lower airways should be performed in patients with allergic rhinitis alone.

Allergic Rhinitis: Natural History. A Twenty Years Follow up Study

2003 ◽  
Vol 1 (1) ◽  
pp. 17-23 ◽  
Author(s):  
D. Passàli ◽  
V. Damiani ◽  
G.C. Passàli ◽  
F.M. Passàli ◽  
L. Bellussi
Keyword(s):  
Allergic Rhinitis ◽  
Natural History ◽  
Symptomatic Treatment ◽  
Follow Up Study ◽  
Number Of Patients ◽  
Asthma Patients ◽  
Lower Airways ◽  
The Relationship

Although there is an agreement on the increase of the prevalence of allergic rhinitis in last decades, data emerging from various studies appear to be widely dishomogeneous. Another point that needs a clarification is the relationship between allergic rhinitis and lower airways pathologies such as asthma or bronchitis. In this study, we followed the evolution of allergic rhinitis in a group of patients in the last 20 years to highlight the efficacy of different treatments in the prevention of complications, specifically asthma. Patients who didn't receive any kind of treatment experimented a remission of symptoms in 4 cases, a stability of the disease in 6 and the development of complications in 11. In the group treated with symptomatic drugs we highlighted a recovery in 11 patients, a stability of symptoms in 2 and complications in 2. At last, patients undergone immunotherapy considered their symptoms improved in 60 % and stable in 40 % of cases. In conclusion, Immunotherapy guarantees, in a large number of patients, remission of local symptoms and valid protection against district and bronchial complications. Symptomatic treatment with antihistamines and/or cortisones represents a valid alternative, and it's always to be preferred to abstention from any treatment.

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