scholarly journals Bronchial hyperreactivity and spirometric impairment in patients with allergic rhinitis

2005 ◽  
Vol 63 (2) ◽  
Author(s):  
I. Cirillo ◽  
A. Vizzaccaro ◽  
M.A. Tosca ◽  
S. Negrini ◽  
A.C. Negrini ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pollen Season ◽  
Seasonal Difference ◽  
Bronchial Hyperreactivity ◽  
Methacholine Challenge ◽  
Careful Evaluation ◽  
Large Group ◽  
Lower Airways ◽  
Significant Seasonal Difference

Background: The Link between allergic rhinitis and asthma is well known. Bronchial hyperreactivity (BHR) may be present in rhinitics. The present study is aimed at evaluating a large group of subjects suffering from allergic rhinitis alone to investigate the presence of spirometric impairment and BHR both during and outside the pollen season. Methods: 360 rhinitics (subdivided in 3 groups: seasonal, SAR, perennial, PAR, and polysensitized, PolysR) were investigated by spirometry and methacholine challenge. Results: There was a significant seasonal difference concerning the number of rhinitics with impaired FEV1 (p<0.01 for SAR, p<0.02 for PAR, and p<0.03 for PolysR) and FEF25-75 (p<0.05 for SAR, p<0.03 for PAR, and p<0.05 for PolysR) as well as with BHR (p<0.05 for SAR and p<0.03 for PAR). Conclusions: This study evidences that an impairment of spirometric parameters and BHR may be observed in patients with allergic rhinitis alone. Thus, careful evaluation of lower airways should be performed in patients with allergic rhinitis alone.

Relationship between Responses to Bronchodilation Testing and to Nasal Decongestion Testing in Patients with Allergic Rhinitis Alone

2009 ◽  
Vol 7 (3) ◽  
pp. 153-160 ◽  
Author(s):  
G. Ciprandi ◽  
A. Pistorio ◽  
M.A. Tosca ◽  
I. Cirillo ◽  
G.L. Marseglia
Keyword(s):  
Allergic Rhinitis ◽  
Skin Prick Test ◽  
Nasal Obstruction ◽  
Clinical Examination ◽  
Positive Response ◽  
Bronchial Obstruction ◽  
Prick Test ◽  
Large Group ◽  
Lower Airways

A remarkable relationship exists between upper and lower airways. Bronchial obstruction is a paramount feature of asthma as well as nasal obstruction of allergic rhinitis (AR). This study aims to evaluate the response to both bronchodilation and decongestion testing and their relationships in a large group of patients with moderate-severe persistent AR alone. Two hundred eleven patients with moderate-severe persistent AR were prospectively and consecutively evaluated. Clinical examination, skin prick test, spirometry, bronchodilation test, rhinomanometry, and decongestion test were performed on all patients. Seventeen subjects (8%) did not respond to any of the tests, 55 subjects (26.1%) were responders only to the decongestion test, 31 (14.7%) only to the bronchodilation test, and 108 subjects (51.2%) responded to both these tests. Longer AR duration was significantly associated with positive response to both tests (p<0.01). In conclusion, this study provides the first evidence that patients with moderate-severe persistent AR may frequently show reversibility to both bronchodilation and decongestion tests.

Nasal reactivity to capsaicin in patients with seasonal allergic rhinitis during and after the pollen season

Allergy ◽  
1999 ◽  
Vol 54 (8) ◽  
pp. 804-810 ◽  
Author(s):  
Ml Kowalski ◽  
A Dietrich-miłobędzki ◽  
B Majkowska-wojciechowska ◽  
M Jarzębska
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Pollen Season

The interaction between upper and lower airways in allergic rhinitis

2001 ◽  
Vol 26 (4) ◽  
pp. 341-341
Author(s):  
W. Fokkens ◽  
G.J. Braunstahl
Keyword(s):  
Allergic Rhinitis ◽  
Lower Airways

Cytokine expression in the lower airways of nonasthmatic subjects with allergic rhinitis: Influence of natural allergen exposure

2000 ◽  
Vol 106 (5) ◽  
pp. 904-910 ◽  
Author(s):  
Jamila Chakir ◽  
Michel Laviolette ◽  
Hélène Turcotte ◽  
Michel Boutet ◽  
Louis-Philippe Boulet
Keyword(s):  
Allergic Rhinitis ◽  
Allergen Exposure ◽  
Cytokine Expression ◽  
Lower Airways

Site-specific sensitization in a murine model of allergic rhinitis: Role of the upper airway in lower airways disease

2002 ◽  
Vol 110 (6) ◽  
pp. 891-898 ◽  
Author(s):  
Christine McCusker ◽  
Martin Chicoine ◽  
Qutayba Hamid ◽  
Bruce Mazer
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Upper Airway ◽  
Site Specific ◽  
Lower Airways

scholarly journals The Effects of Long-Term Administration of Sodium Nedocromil on Bronchial Hypereactivity

2003 ◽  
Vol 1 (3) ◽  
pp. 119-123 ◽  
Author(s):  
G. Ilonidis ◽  
G. Anogianakis ◽  
CH. Trakatelli ◽  
A. Anogeianaki ◽  
M. Chomatidis ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Term Treatment ◽  
Bronchial Hyperreactivity ◽  
Methacholine Challenge ◽  
Intrinsic Asthma ◽  
Group I ◽  
Long Term Treatment ◽  
The Mean ◽  
Group Ii

The effect of long-term treatment with sodium nedocromil on airway hypereactivity was investigated in two groups of 20 patients each. Group I patients presented with allergic asthma while Group II patients presented with intrinsic asthma. For each subject of the two groups, the base FEV1 was measured and nebulized methacholine was administrated in consecutively higher concentrations until a decrease in FEV1 of >20 % was observed. Following measurement, all patients included in the study were treated with 12 mg of sodium nedocromil per day for 12 months. At the end of the treatment, bronchial hyperreactivity was evaluated for a second time by administering the same dosage of methacholine that originally produced a decline in FEV1 of >20 %. In Group I patients (allergic asthma) mean FEV1 was 3126 ml, before challenge, while after methacholine challenge FEV1 was 2400ml. Following 1-year of sodium nedocromil administration the FEV1 was 2601ml (P<0.05). Before treatment, the mean fall in FEV1, following methacholine challenge, was 23.67% while following a 1-year-long sodium nedocromil administration this value reduced to 15.70% (P<0.05). Correspondingly, PC20 was 5.59 while after sodium nedocromil administration it increased to 11.66 (P<0.05). In Group II patients (intrinsic asthma) mean FEV1 was 2750 ml, before challenge, while after methacholine challenge FEV1 was 2066ml. Following 1-year of sodium nedocromil administration the FEV1 was 2223ml (P<0.05). Before treatment, the mean fall in FEV1, following methacholine challenge, was 27.65 % while following a 1-year-long sodium nedocromil administration this value reduced to 21.92 % (P<0.05). Correspondingly, PC20 was 5.91 while after sodium nedocromil administration it increased to 6.19 (P<0.05). The results suggest a positive effect of long-term sodium nedocromil administration in bronchial hyperreactivity for both groups of patients.

scholarly journals The Blood Urokinase System in Patients with Seasonal Allergic Rhinitis and Concomitant Seasonal Asthma during Pollen Season

2011 ◽  
Vol 9 (3) ◽  
pp. 285-288 ◽  
Author(s):  
A. Kasperska-Zajac ◽  
E. Czecior ◽  
A. Grzanka ◽  
E. Machura ◽  
M. Misiolek
Keyword(s):  
Allergic Rhinitis ◽  
Seasonal Allergic Rhinitis ◽  
Pollen Season ◽  
Urokinase System
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