Organ preservation surgery for laryngeal squamous cell carcinoma: Low incidence of thyroid cartilage invasion

2010 ◽  
Vol 120 (6) ◽  
pp. 1173-1176 ◽  
Author(s):  
Dana M. Hartl ◽  
Guillaume Landry ◽  
Stéphane Hans ◽  
Patrick Marandas ◽  
Daniel F. Brasnu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Thyroid Cartilage ◽  
Cartilage Invasion ◽  
Low Incidence

scholarly journals Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion

2009 ◽  
Vol 119 (8) ◽  
pp. 1510-1517 ◽  
Author(s):  
Francis P. Worden ◽  
Jeffrey Moyer ◽  
Julia S. Lee ◽  
Jeremy M. G. Taylor ◽  
Susan G. Urba ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Cartilage Invasion

CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma

2012 ◽  
Vol 270 (1) ◽  
pp. 287-291 ◽  
Author(s):  
Dana M. Hartl ◽  
Guillaume Landry ◽  
François Bidault ◽  
Stéphane Hans ◽  
Morbize Julieron ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Ct Scan ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Thyroid Cartilage ◽  
Cartilage Invasion

Expression of Bcl-2 Family Proteins in Advanced Laryngeal Squamous Cell Carcinoma: Correlation With Response to Chemotherapy and Organ Preservation

2002 ◽  
Vol 112 (4) ◽  
pp. 638-644 ◽  
Author(s):  
Douglas K. Trask ◽  
Gregory T. Wolf ◽  
Carol R. Bradford ◽  
Susan G. Fisher ◽  
Kenneth Devaney ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Response To Chemotherapy

Thyroid cartilage invasion in early-stage squamous cell carcinoma involving the anterior commissure

Head & Neck ◽  
2011 ◽  
Vol 34 (10) ◽  
pp. 1476-1479 ◽  
Author(s):  
Dana M. Hartl ◽  
Guillaume Landry ◽  
Stéphane Hans ◽  
Patrick Marandas ◽  
Odile Casiraghi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Anterior Commissure ◽  
Thyroid Cartilage ◽  
Cartilage Invasion

scholarly journals CT-based radiomics features in the prediction of thyroid cartilage invasion from laryngeal and hypopharyngeal squamous cell carcinoma

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ran Guo ◽  
Jian Guo ◽  
Lichen Zhang ◽  
Xiaoxia Qu ◽  
Shuangfeng Dai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Thyroid Cartilage ◽  
Roc Curves ◽  
Ct Images ◽  
Support Vector ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Cartilage Invasion ◽  
Significant Difference

Abstract Background Laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) with thyroid cartilage invasion are considered T4 and need total laryngectomy. However, the accuracy of preoperative diagnosis of thyroid cartilage invasion remains lower. Therefore, the purpose of this study was to assess the potential of computed tomography (CT)-based radiomics features in the prediction of thyroid cartilage invasion from LHSCC. Methods A total of 265 patients with pathologically proven LHSCC were enrolled in this retrospective study (86 with thyroid cartilage invasion and 179 without invasion). Two head and neck radiologists evaluated the thyroid cartilage invasion on CT images. Radiomics features were extracted from venous phase contrast-enhanced CT images. The least absolute shrinkage and selection operator (LASSO) and logistic regression (LR) method were used for dimension reduction and model construction. In addition, the support vector machine-based synthetic minority oversampling (SVMSMOTE) algorithm was adopted to balance the dataset and a new LR-SVMSMOTE model was constructed. The performance of the radiologist and the two models were evaluated with receiver operating characteristic (ROC) curves and compared using the DeLong test. Results The areas under the ROC curves (AUCs) in the prediction of thyroid cartilage invasion from LHSCC for the LR-SVMSMOTE model, LR model, and radiologist were 0.905 [95% confidence interval (CI): 0.863 to 0.937)], 0.876 (95%CI: 0.830 to 0.913), and 0.721 (95%CI: 0.663–0.774), respectively. The AUCs of both models were higher than that of the radiologist assessment (all P < 0.001). There was no significant difference in predictive performance between the LR-SVMSMOTE and LR models (P = 0.05). Conclusions Models based on CT radiomic features can improve the accuracy of predicting thyroid cartilage invasion from LHSCC and provide a new potentially noninvasive method for preoperative prediction of thyroid cartilage invasion from LHSCC.

scholarly journals Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma

2008 ◽  
Vol 19 (9) ◽  
pp. 1650-1654 ◽  
Author(s):  
B.R. Knab ◽  
J.K. Salama ◽  
A. Solanki ◽  
K.M. Stenson ◽  
E.E. Cohen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Definitive Chemoradiotherapy

Accuracy of magnetic resonance imaging in diagnosing thyroid cartilage and thyroid gland invasion by squamous cell carcinoma in laryngectomy patients

2012 ◽  
Vol 126 (3) ◽  
pp. 302-306 ◽  
Author(s):  
A J Kinshuck ◽  
P W A Goodyear ◽  
J Lancaster ◽  
N J Roland ◽  
S Jackson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Magnetic Resonance ◽  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Thyroid Cartilage ◽  
Resonance Imaging ◽  
Predictive Values ◽  
Cartilage Invasion ◽  
Sensitivity Specificity

AbstractObjectives:We examined the accuracy of magnetic resonance imaging in assessing thyroid cartilage and thyroid gland invasion in patients undergoing total laryngectomy for squamous cell carcinoma, by comparing histopathology results with imaging findings.Study design:A retrospective study reviewed histology and magnetic resonance scan results for all total laryngectomies performed between 1998–2008 at University Hospital Aintree, Liverpool.Methods:Pre-operative magnetic resonance images were reviewed independently by two consultant head and neck radiologists masked to the histology; their opinions were then compared with histology findings.Results:Eighty-one magnetic resonance scans were reviewed. There were 22 laryngectomy patients with histologically verified thyroid cartilage invasion and one patient with thyroid gland invasion. There were 31 patients with apparent radiological thyroid cartilage invasion pre-operatively (with 17 false positives), giving sensitivity, specificity, and positive and negative predictive values of 64, 71, 45 and 84 per cent, respectively. On assessing thyroid gland invasion, there were nine false positive scans and no false negative scans, giving sensitivity, specificity, and positive and negative predictive values of 100, 89, 10 and 100 per cent, respectively.Conclusion:Magnetic resonance scanning over-predicts thyroid cartilage and gland invasion in patients undergoing total laryngectomy. Magnetic resonance scans have limited effectiveness in predicting thyroid cartilage invasion by squamous cell carcinoma in laryngectomy patients.

scholarly journals Oncologic Outcome of Organ-Preservation Surgery in Locally Advanced Laryngeal Squamous Cell Carcinoma

2016 ◽  
Vol 28 (1) ◽  
pp. 5-9
Author(s):  
Hidetoshi Matsui ◽  
Shigemichi Iwae ◽  
Yuji Hirayama ◽  
Koichiro Yonezawa ◽  
Takuji Hayashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Locally Advanced ◽  
Oncologic Outcome

scholarly journals Recurrence of laryngeal squamous cell carcinoma in patients undergoing organ preservation therapy: are there symptoms associated with recurrence?

2019 ◽  
Vol 48 (2) ◽  
Author(s):  
Sonyara Rauedys Lisboa ◽  
Daniel Abreu Rocha ◽  
Richard Godoy Mejia ◽  
Adolfo Cotarelli Sasaki ◽  
Matheus Gerhard Rosenfeld ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma
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