scholarly journals Chemoselection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma with cartilage invasion

2009 ◽  
Vol 119 (8) ◽  
pp. 1510-1517 ◽  
Author(s):  
Francis P. Worden ◽  
Jeffrey Moyer ◽  
Julia S. Lee ◽  
Jeremy M. G. Taylor ◽  
Susan G. Urba ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Cartilage Invasion

Organ preservation surgery for laryngeal squamous cell carcinoma: Low incidence of thyroid cartilage invasion

2010 ◽  
Vol 120 (6) ◽  
pp. 1173-1176 ◽  
Author(s):  
Dana M. Hartl ◽  
Guillaume Landry ◽  
Stéphane Hans ◽  
Patrick Marandas ◽  
Daniel F. Brasnu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Thyroid Cartilage ◽  
Cartilage Invasion ◽  
Low Incidence

Expression of Bcl-2 Family Proteins in Advanced Laryngeal Squamous Cell Carcinoma: Correlation With Response to Chemotherapy and Organ Preservation

2002 ◽  
Vol 112 (4) ◽  
pp. 638-644 ◽  
Author(s):  
Douglas K. Trask ◽  
Gregory T. Wolf ◽  
Carol R. Bradford ◽  
Susan G. Fisher ◽  
Kenneth Devaney ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Response To Chemotherapy

CT-scan prediction of thyroid cartilage invasion for early laryngeal squamous cell carcinoma

2012 ◽  
Vol 270 (1) ◽  
pp. 287-291 ◽  
Author(s):  
Dana M. Hartl ◽  
Guillaume Landry ◽  
François Bidault ◽  
Stéphane Hans ◽  
Morbize Julieron ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Ct Scan ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Thyroid Cartilage ◽  
Cartilage Invasion

scholarly journals Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma

2008 ◽  
Vol 19 (9) ◽  
pp. 1650-1654 ◽  
Author(s):  
B.R. Knab ◽  
J.K. Salama ◽  
A. Solanki ◽  
K.M. Stenson ◽  
E.E. Cohen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Definitive Chemoradiotherapy

scholarly journals Oncologic Outcome of Organ-Preservation Surgery in Locally Advanced Laryngeal Squamous Cell Carcinoma

2016 ◽  
Vol 28 (1) ◽  
pp. 5-9
Author(s):  
Hidetoshi Matsui ◽  
Shigemichi Iwae ◽  
Yuji Hirayama ◽  
Koichiro Yonezawa ◽  
Takuji Hayashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Locally Advanced ◽  
Oncologic Outcome

scholarly journals Recurrence of laryngeal squamous cell carcinoma in patients undergoing organ preservation therapy: are there symptoms associated with recurrence?

2019 ◽  
Vol 48 (2) ◽  
Author(s):  
Sonyara Rauedys Lisboa ◽  
Daniel Abreu Rocha ◽  
Richard Godoy Mejia ◽  
Adolfo Cotarelli Sasaki ◽  
Matheus Gerhard Rosenfeld ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma

Chemo-selection as a strategy for organ preservation in patients with T4 laryngeal squamous cell carcinoma

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6005-6005 ◽  
Author(s):  
F. P. Worden ◽  
G. Wolf ◽  
A. Eisbruch ◽  
J. Lee ◽  
C. R. Bradford ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Induction Chemotherapy ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Residual Disease ◽  
Phase Ii Trials ◽  
Grade 3

6005 Background: We previously reported high rates of overall survival (OS) and laryngeal preservation in two sequential phase II trials with stage III/IV laryngeal squamous cell carcinoma patients (pts), who attained a >50% response after 1 cycle of induction chemotherapy, and who were treated with chemoradiation. Since then, all pts were re-staged to correspond with the most recent American Joint Committee on Cancer staging guidelines. Here we report the outcomes of the T4 pts from both studies. Methods: Pts received 1 cycle of cisplatin 100 mg/m2 & 5-FU 1,000 mg/m2/day × 5 days (P+5FU). Pts with > 50% response received chemoradiation with 70 Gy & P 100 mg/m2, days 1, 22, & 43. Pts with ≤ 50% response underwent laryngectomy. Final planned tumor assessment by direct laryngoscopy with biopsy was performed 8 wks after chemoradiation. Pts who were histologic complete responders, received 2 cycles of P+5FU. Pts with residual disease had planned salvage surgery. Results: Thirty-two T4 eligible (cartilage invasion 31, base of tongue involvement 1) pts were enrolled, 23 M; 9 F; median age 56; stage: IVA 31, IVB 1; site: 19 supraglottic, 13 glottic. After 1 cycle induction chemotherapy, 26 pts (81%) had > 50% response & received chemoradiation; 5 (16%) had surgery; & 1 refused surgery. After chemoradiation, 22 pts had a complete histologic response, & 4 pts required immediate salvage larngectomy for residual disease. Of those responding to chemoradiation, 2 pts eventually required salvage laryngectomy. Currently, 17/32 (53%) are alive (15 without disease), 10 are dead of disease, & 5 are dead from other causes. Toxicity: grade 3/4 granulocytopenia 19%, grade 3/4 mucositis 49%. Median time to follow-up is 45 months. The 3 yr overall survival (OS) is 75% (95% CI=55%, 86%), & the 4 yr OS is 70% (95% CI = 50%, 83%). The 3 yr disease-free survival (DFS) is 77% (CI=58%, 88%), & the 4 yr DFS is 72% (CI=52%, 85%). Conclusions: Our results suggest that chemo-selection is an alternative, organ preservation strategy to total laryngectomy for pts with T4 laryngeal squamous cell carcinoma. No significant financial relationships to disclose.

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