scholarly journals Topical application of Cinnamon verum essential oil accelerates infected wound healing process by increasing tissue antioxidant capacity and keratin biosynthesis

2019 ◽  
Vol 35 (11) ◽  
pp. 686-694 ◽  
Author(s):  
Seyed Gharani Seyed Ahmadi ◽  
Mohammad R. Farahpour ◽  
Hamed Hamishehkar
Keyword(s):  
Wound Healing ◽  
Essential Oil ◽  
Antioxidant Capacity ◽  
Topical Application ◽  
Healing Process ◽  
Wound Healing Process ◽  
Infected Wound

scholarly journals Wound Healing Activity of the Essential Oil of Bursera morelensis, in Mice

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1795
Author(s):  
Judith Salas-Oropeza ◽  
Manuel Jimenez-Estrada ◽  
Armando Perez-Torres ◽  
Andres Eliu Castell-Rodriguez ◽  
Rodolfo Becerril-Millan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Oil ◽  
Cell Viability ◽  
Murine Model ◽  
Biological Activities ◽  
Healing Process ◽  
In Vitro Tests ◽  
Wound Healing Process ◽  
Fibroblast Migration

Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. It is an endemic tree known as “aceitillo”, and the antibacterial and antifungal activity of its essential oil has been verified; it also acts as an anti-inflammatory. All of these reported biological activities make the essential oil of B. morelensis a candidate to accelerate the wound-healing process. The objective was to determine the wound-healing properties of B. morelensis’ essential oil on a murine model. The essential oil was obtained by hydro-distillation, and the chemical analysis was performed by gas chromatography-mass spectrometry (GC-MS). In the murine model, wound-healing efficacy (WHE) and wound contraction (WC) were evaluated. Cytotoxic activity was evaluated in vitro using peritoneal macrophages from BALB/c mice. The results showed that 18 terpenoid-type compounds were identified in the essential oil. The essential oil had remarkable WHE regardless of the dose and accelerated WC and was not cytotoxic. In vitro tests with fibroblasts showed that cell viability was dose-dependent; by adding 1 mg/mL of essential oil (EO) to the culture medium, cell viability decreased below 80%, while, at doses of 0.1 and 0.01 mg/mL, it remained around 90%; thus, EO did not intervene in fibroblast proliferation, but it did influence fibroblast migration when wound-like was done in monolayer cultures. The results of this study demonstrated that the essential oil was a pro-wound-healing agent because it had good healing effectiveness with scars with good tensile strength and accelerated repair. The probable mechanism of action of the EO of B. morelensis, during the healing process, is the promotion of the migration of fibroblasts to the site of the wound, making them active in the production of collagen and promoting the remodeling of this collagen.

scholarly journals PVA-GELATIN HYDROGELS CONTAINING ROSEMARY ESSENTIAL OIL FOR WOUND DRESSINGS

2019 ◽  
Vol 2019 ◽  
pp. 216-219
Author(s):  
Denisa-Maria RADULESCU ◽  
Diana-Elena RADULESCU ◽  
Gabriela-Cristina CONSTANTINESCU ◽  
Laura CHIRILA ◽  
Alina POPESCU
Keyword(s):  
Wound Healing ◽  
Essential Oil ◽  
Healing Process ◽  
Potential Method ◽  
Point Of View ◽  
Wound Dressings ◽  
Esterification Reaction ◽  
Wound Healing Process ◽  
Moist Environment ◽  
Rosemary Essential Oil

Wound healing represents one of the most important processes evaluated in the biomedical field. In this regard, healing is defined as a dynamic and complex process in which the tissue integrity and the normal functions of the damaged tissue are restored. The purpose of this research was to achieve the main characteristics of an ideal wound dressing to prevent maceration, provide a moist environment, remove the exudate that is accumulated from the wound and to maintain a proper permeability to the wound bed. Different hydrogels were designed and developed through the esterification reaction of polyvinyl alcohol (PVA) with gelatin (GELL). The hydrogels were prepared in various weight ratios of PVA:GELL (4:1 and 1:4), by adding rosemary essential oil as an active compound. The incorporation of Rosemarinus officinalis L (rosemary) essential oil in PVA/GELL hydrogels represents a potential method for the improvement of the wound healing process. Further, the developed hydrogels were applied by immersion on cotton gauze. The synthetized specimens were evaluated from morphological and rheological point of view, by performing Optical Microscopy, fluid uptake ability and porosity measurements.

scholarly journals Efek aplikasi topikal gel ekstrak pandan wangi terhadap penyembuhan luka gingiva

2017 ◽  
Vol 2 (2) ◽  
pp. 53
Author(s):  
Icha Nofikasari ◽  
Afifah Rufaida ◽  
Chynintia Dewi Aqmarina ◽  
Failasofia Failasofia ◽  
Annisa Rahmi Fauzia ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Vessel ◽  
Topical Application ◽  
Healing Process ◽  
Punch Biopsy ◽  
Positive Control ◽  
Negative Control ◽  
Wound Healing Process ◽  
Wound Area ◽  
Pandanus Amaryllifolius

The Effect of topical application pandan extract gel on gingival wound. Post-gingivectomy wound is usually covered by periodontal dressing, which generally contains some chemical compounds to protect the wound. However, it can provide allergic effect on some patients. Pandan leaves (Pandanus amaryllifolius Roxb.) contain a number of active substances that have anti-inflammatory, antioxidant and antibacterial effect and play a role in wound healing. This study aims to determine the effect of topical application of Pandan leaf extract gel on gingival wound healing. Gingivectomy model was carried out on mandibular incisive gingival using the 2.5-mm punch biopsy. Thirty-six rats were randomly divided into 3 groups of treatment: negative control (CMC-Na), positive control (Aloclair), and 50% of pandan extract gel. The gels on each group were applied (twice in a day) to the wound area after gingivectomy. The observation of the wound healing process was also carried out on day 1, 3, 7, and 14 by making the histological preparations of gingival wound area. The number of blood vessels was observed using microscope and data was analysed using Two- Way Anova and LSD. The result showed that number of blood vessel increased on day 3 and the peak was on day 7. Anova and LSD test showed several significant differences comparison the number blood vessel between treatment and control. In conclusion, topical application Pandan leaves extract gel could accelerate gingival wound healing.ABSTRAKLuka pasca gingivektomi dibalut dengan periodontal dressing yang mengandung senyawa kimia dengan tujuan melindungi luka, namun senyawa kimia periodontal dressing yang ada di pasaran dapat menimbulkan efek alergi terhadap beberapa pasien. Daun pandan wangi (Pandanus amaryllifolius Roxb.) mengandung zat aktif yang memiliki anti inflamasi, antioksidan, dan antibakteri kemungkinan berperan dalam proses penyembuhan luka. Penelitian ini bertujuan untuk mengetahui peran gel ekstrak daun pandan wangi dalam proses penyembuhan luka pasca gingivektomi pada tikus wistar melalui pengamatan jumlah pembuluh darah. Model gingivektomi dilakukan pada gingiva incisivus mandibula dengan menggunakan punch biopsy diameter 2,5 mm. Tiga puluh enam tikus dibagi secara acak ke dalam 3 kelompok perlakuan yaitu kontrol negatif (Gel CMC-Na), kontrol positif (Aloclair), dan gel ekstrak pandan wangi 50%. Gel uji pada masing- masing kelompok diaplikasikan pada area luka pasca gingivektomi dua kali sehari. Pengamatan proses penyembuhan luka dilakukan pada hari ke 1, 3, 7, dan 14 dengan membuat preparat histologi gingiva area luka. Parameter penyembuhan luka yang diamati adalah jumlah pembuluh darah. Data jumlah pembuluh darah dianalisis dengan menggunakan uji statistik parametrik. Hasil penelitian menunjukkan jumlah pembuluh darah mengalami peningkatan mulai hari ke-3 dan mencapai puncaknya pada hari ke-7. Hasil uji two way Anova menunjukkan adanya perbedaan yang bermakna rerata jumlah pembuluh darah antar kelompok perlakuan dengan kontrol positif maupun negatif (p<0,05). Hasil uji LSD juga menunjukkan perbedaan yang bermakna perbandingan kelompok kontrol dan perlakuan pada semua hari pengamatan. Kesimpulan penelitian ini adalah gel ekstrak pandan wangi 50% dapat mempercepat proses penyembuhan luka pasca gingivektomi dengan kemampuannya meningkatkan jumlah pembuluh darah.

scholarly journals KHASIAT MADU PADA PENYEMBUHAN LUKA KULIT

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Sonny J R Kalangi
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Microbial Growth ◽  
Healing Process ◽  
High Viscosity ◽  
Wound Healing Process ◽  
Physical Barrier

Abstract: The topical application of honey on a wound is effective in controlling the wound healing process and results in clean granulation tissues in the wound base. Honey acts as a hyperosmolar medium and prevents microbial growth. Besides that, honey has a high viscosity that forms a physical barrier and cretaes a wet environmet which is very effective in accelerating wound healing. Nutrients in honey increase the supply of local substances that might be useful in reepithelization. In addition, honey contains a catalase enzyme that can influence wound healing.Keywords: honey, wound healingAbstrak: Pemberian madu topikal efektif dalam mengontrol dan menghasilkan dasar luka bergranulasi bersih. Madu bekerja terutama sebagai medium hiperosmolar dan mencegah pertumbuhan bakteri. Madu juga memiliki viskositas tinggi yang membentuk sawar fisik dan menciptakan lingkungan basah; sifat tersebut yang membantu dan mempercepat penyembuhan luka. Kandungan bahan makanan dari madu menambah pasokan bahan lokal yang mungkin membantu mempercepat reepitelisasi. Disamping itu, madu mengandung enzim katalase yang juga mempengaruhi proses penyembuhan luka.Kata kunci: madu, penyembuhan luka

Evaluation of the Surgery Wound Healing Process Using Self–Adaptive Skin Suture or Mechanical Stapler

2016 ◽  
Vol 88 (4) ◽  
Author(s):  
Ewa Sztuczka ◽  
Marek Jackowski ◽  
Wioletta Żukowska
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Period ◽  
Skin Layer ◽  
Wound Healing Process ◽  
Skin Closure ◽  
Infected Wound ◽  
Control And Prevention ◽  
Mechanical Stapler ◽  
Self Adaptive

AbstractWound healing is a complex and time-phased process. The occurrence of numerous negative conditions as well as external factors have a significant influence on the risk of potential complications. Preparing the patient for surgery, attention should be paid to a number of factors determining the proper healing process.The aim of the study was to compare the results of the early period of surgical wound healing process with access via laparotomy using techniques, which are self-adaptive sutures and mechanical staplers used for skin closure.Material and methods. The study included 120 patients divided into three groups, according to the degree of wound continence, in accordance with the CDC (Center for Disease Control and Prevention). Exclusion criteria based on objective analysis were applied for patients with a higher risk of complications. In all cases the skin layer was closed with monofilament suture or single-patient use stapler. A ten-day observation of the wound healing process was implemented. The study was randomized.Results. In the case of patients groups identified as a “Clean Wound” and “ Clean / Infected Wound” no significant differences were discovered. In the group “Contaminated/Infected Wound” significantly higher percentage of wound-healing complications were reported (p < 0.05) for which monofilament sutures was used.Conclusions. The study showed, that mechanical stapler is recommended for contaminated/infected surgical wounds due to significantly lower risk of complications. In the case of wounds divided as a “Clean” and “Clean/Infected” type of suturing material has no significant effect on wound healing.

scholarly journals Topical application of silver-curcumin on wound healing in rabbits

2016 ◽  
Vol 32 (2) ◽  
pp. 55-64
Author(s):  
R Islam ◽  
UK Rima ◽  
MM Haq ◽  
MM Hossain ◽  
MM Rahman ◽  
...  
Keyword(s):  
Wound Healing ◽  
Connective Tissue ◽  
Topical Application ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Wound Management ◽  
Control Group ◽  
Wound Healing Process ◽  
Fibrous Connective Tissue ◽  
Positive Effects

Curcumin, a natural product obtained from the rhizomes of Curcuma longa, is used traditionally in prevention of wound infection. To determine the effects of silver and curcumin combination on surgical wound healing, a study was conducted in rabbits. A total of 32 surgical wounds were created in 16 rabbits in four groups. Information was recorded from Day 0 to Day 42 postoperatively. Swelling area of wound, elevation of suture line from the skin surface, width of sutured area and contraction length were recorded weekly. Treatment with curcumin, 1% silver sulfadiazine (1% SSD) and a mixture of the two resulted in swelling of 11.4 ± 0.1 mm, 11.1 ± 0.4 mm and 11.0 ± 0.1 mm, respectively. Swelling (12.2 ± 0.3mm) and elevation of sutured line was higher (3.4 ± 0.2 mm) in wounds of control group and lower (2.3 ± 0.1 mm) in wounds treated with a mixture of curcumin and 1% SSD. The scores of wound colonization were lowest (0.8) in 1% SSD group followed by mixture of curcumin and 1% SSD (1.0), curcumin (1.3) and tincture of benzoin (1.6) alone. Histopathologically reactive cells decreased markedly in wounds treated with combination of 1% SSD and curcumin at D3 with increased fibrous connective tissue. However, wounds treated with 1% SSD showed fewer reactive cells than curcumin group. Proliferation of fibrous connective tissue was highest in the silver treated wound, which indicates good wound healing process. Overall, wound healing was improved by the topical application of 1% SSD alone. Curcumin had positive effects on wound healing process but less than 1% SSD. These results indicate that 1% silver sulfadiazine is the best topical therapy for wound management in rabbits.Bangl. vet. 2015. Vol. 32, No. 2, 55-64

scholarly journals Effect of Topical Application of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Paste in Wound Healing Process in Mice

2014 ◽  
Vol 1 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Gurwinder Kaur a/p Gurcharan Singh ◽  
Novi Vicahyani Utami ◽  
Hermin Aminah Usman
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Healing Process ◽  
Wound Healing Process

scholarly journals Evaluation of the alcoholic extract of Dipteryx alata Vogel almonds and bark in skin wound healing in C57BL6 mice

2021 ◽  
Vol 73 (6) ◽  
pp. 1315-1322
Author(s):  
M.C.P. Gouveia ◽  
B.W. Minto ◽  
L.F. Sargi ◽  
R.L. Souza ◽  
J.M. Pazzini ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Healing Process ◽  
Skin Wound ◽  
Bark Extract ◽  
Wound Healing Process ◽  
Alcoholic Extract ◽  
Skin Wound Healing ◽  
Significant Difference ◽  
Dipteryx Alata

ABSTRACT The aim of this study was to evaluate the topical application of alcoholic extracts of Dipteryx alata Vogel almonds and bark in skin wound healing in mice. Fifty-four C57BL/6 mice were equally distributed into three groups: Control, Almond, and Bark. A 9 mm skin fragment was resected from the dorsal region of the animals’ thorax. The wounds were submitted to topical application of base cream (vehicle), 10% hydroalcoholic almond extract, or bark extract twice a day. Macroscopic, histological, and immunohistochemical evaluations were conducted on the 7th, 14th, and 21st postoperative days. No significant difference was observed regarding skin wound area among groups, with the parameter presenting only a temporal effect on healing (p>0.05). The almond and control groups exhibited more intense collagenization than the bark group (p<0.05). Dipteryx alata Vogel showed to be inert in the wound healing process in mice.

scholarly journals Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing: In Vitro and In Vivo Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Najmeh Khanbanha ◽  
Fatemeh Atyabi ◽  
Azade Taheri ◽  
Fatemeh Talaie ◽  
Mirgholamreza Mahbod ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Healing Process ◽  
Tissue Growth ◽  
In Vivo Studies ◽  
Wound Healing Process ◽  
Beneficial Effects ◽  
Linear Viscoelastic

To accomplish an ideal wound healing process which promotes healthy tissue growth with less scaring, a novel gel based topical drug delivery system composed of 3 different polymers chitosan, dextran sulfate, and polyvinylpyrrolidone K30 (CDP) was prepared. The physicochemical properties of the prepared gels were investigated in vitro. Gels showed a maximum swelling ratio of 50 ± 1.95 times of dried gel in PBS at pH 7.4. The swelling ratios increase in acidic and alkaline pH to 55.3 ± 1.75 and 65.5 ± 2.42, respectively. In the rheological test, prepared gels revealed viscoelastic properties and a small linear viscoelastic region of 0.166%. In vivo wound healing promoting activities of CDP gels containing 20 μg/mL EGF were evaluated on surgically induced dermal wounds in rats using pathologic examination. The application of CDP gel with incorporated EGF significantly reduced the defect on the rat’s skin and enhanced epithelial healing compared with the topical application of the EGF-free CDP gel. The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring.

Sign in / Sign up

Export Citation Format

Share Document