Oxidation by Permanganate in strong alkaline medium. Oxidation of ethane-1,2-diol, glycol aldehyde, glycollic acid, and glyoxylic acid

1992 ◽  
Vol 24 (2) ◽  
pp. 145-154 ◽  
Author(s):  
J. Szammer ◽  
M. Jáky ◽  
O. V. Gerasimov
Keyword(s):  
Alkaline Medium ◽  
Glyoxylic Acid ◽  
Glycollic Acid ◽  
Glycol Aldehyde

CHEMICAL EFFECTS OF THE C12(γ,n)C11 REACTION IN CARBONATES

1956 ◽  
Vol 34 (3) ◽  
pp. 189-192 ◽  
Author(s):  
W. J. Edwards ◽  
K. J. McCallum
Keyword(s):  
Carbon Monoxide ◽  
Calcium Carbonate ◽  
Oxalic Acid ◽  
Sodium Bicarbonate ◽  
Formic Acid ◽  
Glyoxylic Acid ◽  
Photoneutron Reaction ◽  
Carbonate Carbon ◽  
Chemical Effects ◽  
Glycollic Acid

The chemical effects following the carbon photoneutron reaction in calcium carbonate and sodium bicarbonate have been studied. After solution of the irradiated crystals, C11 was found to be present in the forms of carbonate, carbon monoxide, formic acid, oxalic acid, glyoxylic acid, and glycollic acid. The relative amounts of C11 appearing in each form agreed closely with those found previously for irradiations of solid sodium carbonate.

Kinetics and Mechanism of Oxidation of Labetalol by Hexacyanoferrate(III) in Alkaline Medium

2012 ◽  
Vol 3 (2) ◽  
pp. 131-133
Author(s):  
ANNAPURNA NOWDURI ◽  
◽  
Apparao Babu Duggada ◽  
Vijaya Raju Kurimella
Keyword(s):  
Alkaline Medium ◽  
Kinetics And Mechanism ◽  
Mechanism Of Oxidation

Lemon Juice Mediated Synthesis of 3-Substituted Quinazolin-4(3H)-Ones and their Pharmacological Evaluation

2020 ◽  
Vol 19 (16) ◽  
pp. 2001-2009 ◽  
Author(s):  
Malavattu G. Prasad ◽  
C. Vijaya Lakshmi ◽  
Naresh K. Katari ◽  
Sreekantha B. Jonnalagadda ◽  
Manojit Pal
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Hek293 Cell ◽  
Glyoxylic Acid ◽  
Lemon Juice ◽  
Cytotoxic Agents ◽  
Diverse Range ◽  
Hek293 Cell Line ◽  
Three Component Reaction ◽  
Mcf 7

Background: Compounds containing the quinazoline-4(3H)-one framework constitute an important class of fused N-heterocycles that are found in more than 200 naturally occurring alkaloids. These compounds also show a diverse range of pharmacological activities including antitumor properties. This prompted us to explore a series of quinazolin-4-(3H)-one derivatives having no substituent at C-2 as potential cytotoxic agents. Objective: The objective of this study was to synthesize and evaluate 3-substituted quinazolin-4(3H)-one derivatives for their potential cytotoxic properties. Methods: A convenient method has been developed for the rapid synthesis of this class of compounds under a mild and non-hazardous reaction condition in good yields. The methodology involved a three-component reaction employing isatoic anhydride, amines and glyoxylic acid as reactants in the presence of lemon juice in PEG- 400 at room temperature (25-30ºC) under ultrasound irradiation. All the synthesized compounds were screened via an MTT assay for their potential cytotoxic properties in vitro using the cancerous cell lines e.g. A549, A2780, HepG2, K562, MCF-7 and HCT-116 and a non-cancerous HEK293 cell line. Results: Several compounds such as 3a, 3b, 3d, 3e and 3f showed promising growth inhibition against these cancer cell lines but no significant effects on HEK293 cell line. The IC50 values of these compounds were comparable to doxorubicin whereas 3f significantly induced apoptosis in MCF-7 cells that also was comparable to doxorubicin. Conclusion: An ultrasound-assisted MCR facilitated by lemon juice has been developed to synthesize 3- substituted quinazolin-4(3H)-one derivatives that could act as potential anticancer agents.

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