Rate constants and kinetic isotope effects for hydrogen/deuterium abstraction by chlorine atoms from the chloromethyl group in CH2ClCH2Cl, CD2ClCD2Cl, CH2ClCHCl2, and CH2ClCDCl2

1986 ◽  
Vol 18 (5) ◽  
pp. 513-527 ◽  
Author(s):  
E. Tschuikow-Roux ◽  
F. Faraji ◽  
Jan Niedzielski
Keyword(s):  
Rate Constants ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Chloromethyl Group ◽  
Chlorine Atoms ◽  
Kinetic Isotope ◽  
Hydrogen Deuterium

Competitive photochlorination and kinetic isotope effects for hydrogen/deuterium abstraction from the methyl group in C2H6, C2D6, CH3CHCl2, CD3CHCl2, CH3CCl3, and CD3CCl3

1985 ◽  
Vol 63 (5) ◽  
pp. 1093-1099 ◽  
Author(s):  
E. Tschuikow-Roux ◽  
Jan Niedzielski ◽  
F. Faraji
Keyword(s):  
Temperature Dependence ◽  
Isotope Effect ◽  
Kinetic Isotope Effect ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Arrhenius Law ◽  
Chloromethyl Group ◽  
Methyl Group ◽  
Kinetic Isotope ◽  
Hydrogen Deuterium

The abstraction of hydrogen and deuterium from ethane, 1,1-dichloroethane, 1,1,1-trichloroethane, and some of their deuterated analogs by photochemically generated ground state chlorine atoms has been investigated in the temperature range 7–95 °C using methane as competitor. Rate constants and their temperature coefficients are reported for the following reactions:[Formula: see text]An Arrhenius law temperature dependence was observed in all cases. Mixed primary and α-secondary kinetic isotope effects are k1/k2 = 2.79 ± 0.27, k4/k6 = 4.13 ± 0.32, k7/k8 = 1.46 ± 0.12 at 298 K and decrease to k1/k2 = 2.53 ± 0.22, k4/k6 = 4.06 ± 0.28, k7/k8 = 1.45 ± 0.09 at 370 K, showing a "normal" temperature dependence. The kinetic isotope effect for H/D abstraction from the methyl group decreases with increasing number of chlorine substituents in the adjacent chloromethyl group. The β-secondary isotope effect, k3/k5, is close to unity and shows a slight inverse temperature dependence.

A Theoretical Analysis of Rate Constants and Kinetic Isotope Effects Corresponding to Different Reactant Valleys in Lactate Dehydrogenase

2006 ◽  
Vol 128 (51) ◽  
pp. 16851-16863 ◽  
Author(s):  
Silvia Ferrer ◽  
Iñaki Tuñón ◽  
Sergio Martí ◽  
Vicente Moliner ◽  
Mireia Garcia-Viloca ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Theoretical Analysis ◽  
Rate Constants ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope
Sign in / Sign up

Export Citation Format

Share Document