Hydrogen/deuterium abstraction by chlorine atoms from gaseous ethyl chlorides. Secondary kinetic isotope effects in the system CH3CH2Cl, CH3CHDCl, CH3CD2Cl

1984 ◽  
Vol 16 (6) ◽  
pp. 621-631 ◽  
Author(s):  
J. Niedzielski ◽  
E. Tschuikow-Roux ◽  
T. Yano
Keyword(s):  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Chlorine Atoms ◽  
Kinetic Isotope ◽  
Hydrogen Deuterium

Isotope effects in nucleophilic substitution reactions. V. The mechanism of the decomposition of 1-phenylethyldimethylphenylammonium halides in chloroform

1986 ◽  
Vol 64 (6) ◽  
pp. 1206-1214 ◽  
Author(s):  
Helen Alma Joly ◽  
Kenneth Charles Westaway
Keyword(s):  
Ground State ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Steric Effects ◽  
Halide Ions ◽  
Substitution Reactions ◽  
Kinetic Isotope ◽  
Hydrogen Deuterium ◽  
Primary Substrate ◽  
Triple Ion

Secondary α and β hydrogen–deuterium kinetic isotope effects have been used together to show that the SN reaction between 1-phenylethyldimethylphenylammonium ion and bromide or iodide ion in chloroform occurs by way of an SN2 mechanism within a triple ion in spite of the fact that it reacts faster than the primary substrate, benzyldimethylphenylammonium bromide. The very loose transition state and steric effects in the ground state appear to be responsible for the unusually fast SN2 reactions between 1-phenylethyldimethylphenylammonium ion and halide ions in chloroform.

NMR Stratagems for the Study of Multiple Kinetic Hydrogen/Deuterium Isotope Effectsof Proton Exchange. Example: Di-p-fluorophenylformamidine/THF

1989 ◽  
Vol 44 (5) ◽  
pp. 459-472
Author(s):  
Hans-Heinrich Limbach ◽  
Ludger Meschede ◽  
Gerd Scherer
Keyword(s):  
Nmr Spectroscopy ◽  
Magnetization Transfer ◽  
Isotope Effects ◽  
Geometric Mean ◽  
Kinetic Isotope Effects ◽  
Proton Exchange ◽  
Exchange Reactions ◽  
H Nmr ◽  
Kinetic Isotope ◽  
Hydrogen Deuterium

Stratagems are presented for the determination of kinetic isotope effects of proton exchange reactions by dynamic NMR spectroscopy. In such experiments, lineshape analyses and/or polarization transfer experiments are performed on the exchanging protons or deuterons as well as on remote spins, as a function of the deuterium fraction in the mobile proton sites. These methods are NMR analogs of previous proton inventory techniques involving classical kinetic methods. A theory is developed in order to derive the kinetic isotope effects as well as the number of transferred protons from the experimental NMR spectra. The technique is then applied to the problem of proton exchange in the system 15N,15N′-di-p-fluorophenylibrmamidine, a nitrogen analog of formic acid, dissolved in tetrahydrofuran-d8 (THF). DFFA forms two conformers in THF to which s-trans and s-cis structures have been assigned. Only the s-trans conformer is able to dimerize and exchange protons. Lineshape simulations and magnetization transfer experiments were carried out at 189,2 K, at a concentration of 0.02 mol l-1, as a function of the deuterium fraction D in the 1H-15N sites. Using 1H NMR spectroscopy, a linear dependence of the inverse proton lifetimes on D was observed. From this it was concluded that two protons are transported in the rate limiting step of the proton exchange. This result is expected for a double proton transfer in an s-trans dimer with a cyclic structure. The full kinetic HH/HD/DD isotope effects of 233:11:1 at 189 K were determined through 19F NMR experiments on the same samples. The deviation from the rule of geometric mean, although substantial, is much smaller than found in previous studies of intramolecular HH transfer reactions. Possible causes of this effect are discussed.

scholarly journals The hydrogen kinetic isotope effects of the reactions of n-alkanes with chlorine atoms in the gas phase

2006 ◽  
Vol 53 (1) ◽  
pp. 91-91
Author(s):  
R. Iannone ◽  
R. S. Anderson ◽  
A. Vogel ◽  
P. S. Eby ◽  
M. J. Whiticar ◽  
...  
Keyword(s):  
Gas Phase ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Chlorine Atoms ◽  
Kinetic Isotope
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