Oxidation of metronidazole with sodiumN-bromo-p-toluenesulfonamide in acid and alkaline media: A kinetic and mechanistic study

2005 ◽  
Vol 37 (11) ◽  
pp. 700-709 ◽  
Author(s):  
Puttaswamy ◽  
R. V. Jagadeesh ◽  
N. M. Made Gowda
Keyword(s):  
Alkaline Media ◽  
Mechanistic Study

scholarly journals Kinetics and Mechanistic Study of Hydrolysis of Adenosine Monophosphate Disodium Salt (AMPNa2) in Acidic and Alkaline Media

2019 ◽  
Vol 17 (1) ◽  
pp. 544-556
Author(s):  
Yoke-Leng Sim ◽  
Beljit Kaur
Keyword(s):  
Rate Constant ◽  
Adenosine Monophosphate ◽  
Disodium Salt ◽  
Second Order ◽  
Information Storage ◽  
Alkaline Media ◽  
Basic Medium ◽  
Mechanistic Study ◽  
Phosphate Ester ◽  
Hydrolysis Of

AbstractPhosphate ester hydrolysis is essential in signal transduction, energy storage and production, information storage and DNA repair. In this investigation, hydrolysis of adenosine monophosphate disodium salt (AMPNa2) was carried out in acidic, neutral and alkaline conditions of pH ranging between 0.30-12.71 at 60°C. The reaction was monitored spectrophotometrically. The rate ranged between (1.20 ± 0.10) × 10-7 s-1 to (4.44 ± 0.05) × 10-6 s-1 at [NaOH] from 0.0008 M to 1.00M recorded a second-order base-catalyzed rate constant, kOH as 4.32 × 10-6 M-1 s-1. In acidic conditions, the rate ranged between (1.32 ± 0.06) × 10-7 s-1 to (1.67 ± 0.10) × 10-6 s-1 at [HCl] from 0.01 M to 1.00 M. Second-order acid-catalyzed rate constant, kH obtained was 1.62 × 10-6 M-1 s-1. Rate of reaction for neutral region, k0 was obtained from graphical method to be 10-7 s-1. Mechanisms were proposed to involve P-O bond cleavage in basic medium while competition between P-O bond and N-glycosidic cleavage was observed in acidic medium. In conclusion, this study has provided comprehensive information on the kinetic parameters and mechanism of cleavage of AMPNa2 which mimicked natural AMP cleavage and the action of enzymes that facilitate its cleavage.

Kinetic and mechanistic study of methanol oxidation on a Pt(111) surface in alkaline media

1996 ◽  
Vol 418 (1-2) ◽  
pp. 9-20 ◽  
Author(s):  
A.V. Tripković ◽  
K.Dj. Popović ◽  
J.D. Momčilović ◽  
D.M. Draić
Keyword(s):  
Methanol Oxidation ◽  
Alkaline Media ◽  
Mechanistic Study

Kinetic and mechanistic study of hydroxyl ion electrosorption at the Pt(111) surface in alkaline media

1999 ◽  
Vol 466 (2) ◽  
pp. 155-164 ◽  
Author(s):  
D.M Dražić ◽  
A.V Tripković ◽  
K.D Popović ◽  
J.D Lović
Keyword(s):  
Alkaline Media ◽  
Mechanistic Study ◽  
Hydroxyl Ion

Kinetic and mechanistic study of methanol oxidation on a Pt(100) surface in alkaline media

1998 ◽  
Vol 448 (2) ◽  
pp. 173-181 ◽  
Author(s):  
A.V. Tripković ◽  
K.Dj. Popović ◽  
J.D. Momčilović ◽  
D.M. Dražić
Keyword(s):  
Methanol Oxidation ◽  
Alkaline Media ◽  
Mechanistic Study
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