scholarly journals Repeatability and Reproducibility of the Ultrasonic Attenuation Coefficient and Backscatter Coefficient Measured in the Right Lobe of the Liver in Adults With Known or Suspected Nonalcoholic Fatty Liver Disease

2018 ◽  
Vol 37 (8) ◽  
pp. 1913-1927 ◽  
Author(s):  
Aiguo Han ◽  
Michael P. Andre ◽  
Lisa Deiranieh ◽  
Elise Housman ◽  
John W. Erdman ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Ultrasonic Attenuation ◽  
Backscatter Coefficient ◽  
Nonalcoholic Fatty Liver ◽  
Right Lobe ◽  
Repeatability And Reproducibility ◽  
The Right

scholarly journals Associations between Phase Angle Values Obtained by Bioelectrical Impedance Analysis and Nonalcoholic Fatty Liver Disease in an Overweight Population

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Guangya Chen ◽  
Yi Lv ◽  
Wei Ni ◽  
Qingxin Shi ◽  
Xingliang Xiang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Impedance Analysis ◽  
Whole Body ◽  
Regression Analyses ◽  
Nonalcoholic Fatty Liver ◽  
The Right

Objective. There is a limited diagnosis of nonalcoholic fatty liver disease (NAFLD). Thus, the noninvasive assessments are worth exploring. We determined the associations of phase angles (PhAs) obtained from bioelectric impedance analysis (BIA) with the risk of NAFLD in an overweight population. Methods. A study involving 953 overweight participants was conducted in Wuhan city, China. The associations between PhAs (right arm, left arm, body trunk, right leg, left leg, and whole body) and the risk of NAFLD were conducted using multivariate logistic regression analyses. The associations of PhAs with the controlled attenuation parameter (CAP), a noninvasive assessment of liver steatosis and fibrosis, were also evaluated by both linear and logistic regression analyses. Results. The PhA values of the whole body, trunk, and legs were significantly lower (P<0.05) in the NAFLD group than the non-NAFLD group. After adjustment for BMI, gender, education, income/year, hyperlipidemia, hypertension, diabetes, smoking, passive smoking, and drinking, significant associations of PhA values of the right leg, left leg, and whole body with the risk of NAFLD were observed. In addition, the PhA of the right leg, left leg, and whole body were significantly related to the CAP values. Further stratified analyses indicated that these associations were significant in the participants with BMI <30, but not in the participants with BMI ≥30. Conclusions. PhAs might be effective indicators in the management of NAFLD among overweight people.

scholarly journals Low Bone Mineral Density in Chinese Adults with Nonalcoholic Fatty Liver Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ran Cui ◽  
Hui Sheng ◽  
Xue-Fei Rui ◽  
Xiao-Yun Cheng ◽  
Chun-Jun Sheng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bone Mineral ◽  
Fatty Liver Disease ◽  
Mineral Density ◽  
Chinese Adults ◽  
Nonalcoholic Fatty Liver ◽  
The Right

Aim. To investigate bone metabolic characteristics in Chinese adults with nonalcoholic fatty liver disease (NAFLD).Methods. A total of 224 patients (99 males and 125 postmenopausal females) were recruited and divided into 4 groups: males without NAFLD, males with NAFLD, females without NAFLD, and females with NAFLD. Bone mineral density (BMD) was evaluated according to body mass index (BMI), waist circumference (WC), and serum biomarkers.βcell function was evaluated by HOMA2%B, HOMA2%S, and HOMA2IR.Results. Males in the NAFLD group had lower BMD of the right hip and the femoral neck (0.852±0.117versus0.930±0.123,P=0.002;0.736±0.119versus0.812±0.132,P=0.004), and females had lower BMD of the right hip (0.725±0.141versus0.805±0.145,P=0.002) even after adjusted for weight, BMI, waist, HDL, and ALT. There was no significant difference in bone metabolic markers between patients with and without NAFLD. NAFLD was an important factor that affected the bone; moreover, the effect attenuated when HOMA2IR entered into the model (R2=0.160,β=−0.172, andP=0.008).Conclusions. NAFLD exerts a detrimental effect on BMD in both males and females. Insulin resistance may play an important role in this pathophysiological process.

scholarly journals Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease

PPAR Research ◽  
2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Nan Wang ◽  
Rui Kong ◽  
Hui Luo ◽  
Xiaorong Xu ◽  
Jie Lu
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Drug Targets ◽  
Peroxisome Proliferator ◽  
Lifestyle Modifications ◽  
Nonalcoholic Fatty Liver ◽  
Insulin Resistant ◽  
The Right

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of chronic liver disease worldwide. Concurrent to an increase in NAFLD prevalence, there is an increase in the obesity epidemic and the correlated insulin-resistant state. It is a challenge to diagnose NAFLD because many patients are asymptomatic until the later stages of disease. The most common symptoms include fatigue, malaise, and discomfort in the right upper quadrant. The major and most accurate tool to clinically diagnose NAFLD is a liver biopsy, followed by histological analysis. However, this procedure is invasive and often carries a high risk of complications. Currently, there are no officially approved medications for the treatment of NAFLD. Although lifestyle modifications with proper diet and exercise have been shown to be beneficial, this has been difficult to achieve and sustain for many patients. Effective pharmacological treatments are still lacking; therefore, additional research to identify novel drugs is clearly warranted. PPARs are promising drug targets for the management of NAFLD and its related conditions of type 2 diabetes mellitus and cardiovascular disease. In this review, we provide an overview of recent studies on the association of PPARs and NAFLD.

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